PMID- 25175821
OWN - NLM
STAT- MEDLINE
DCOM- 20150831
LR  - 20160511
IS  - 2042-6984 (Electronic)
IS  - 2042-6976 (Linking)
VI  - 4
IP  - 12
DP  - 2014 Dec
TI  - Is vitamin D insufficiency to blame for recurrent wheezing?
PG  - 980-5
LID - 10.1002/alr.21401 [doi]
AB  - BACKGROUND: Vitamin D (VitD) and its metabolites play important roles in the 
      regulation of the respiratory and immune systems. The aim of this study was to 
      examine serum 25(OH) vitamin D [25(OH)D] levels and VitD deficiency on the 
      development of wheezing and clinical features. METHODS: This study was a 
      prospective cross-sectional survey that included a total of 70 infants being 
      followed in the Pediatric Immunology and Allergy Unit at Ondokuz Mayis 
      University. Forty of these infants (patient group), ranging in age from 1 to 3 
      years, had been diagnosed as wheezy infants; 30 were age-and-gender matched 
      healthy infants (control group). Prior to the study, blood samples were taken 
      from both groups to determine their serum VitD, blood eosinophil, and serum 
      immunoglobulin E (IgE) levels. RESULTS: The duration of breastfeeding was similar 
      for both groups. The serum 25(OH)D levels of the patient group were significantly 
      lower than those of the control group. Although there was a negative relationship 
      between 25(OH)D level and IgE(log10) values for the wheezy infants with VitD 
      deficiency, the control group had a negative relationship between VitD level and 
      IgE(log10) . CONCLUSION: Serum 25(OH)D levels must be evaluated when following 
      wheezy infants, and those with deficiency must be treated with VitD.
CI  - (c) 2014 ARS-AAOA, LLC.
FAU - Demirel, Soner
AU  - Demirel S
AD  - Division of Pediatric Allergy and Clinical Immunology, Faculty of Medicine, 
      Ondokuz Mayis University, Samsun, Turkey.
FAU - Guner, Sukru Nail
AU  - Guner SN
FAU - Celiksoy, Mehmet Halil
AU  - Celiksoy MH
FAU - Sancak, Recep
AU  - Sancak R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140831
PL  - United States
TA  - Int Forum Allergy Rhinol
JT  - International forum of allergy & rhinology
JID - 101550261
RN  - 1406-16-2 (Vitamin D)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Child, Preschool
MH  - Cross-Sectional Studies
MH  - Eosinophils/immunology
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Infant
MH  - Male
MH  - Prospective Studies
MH  - Respiratory Sounds/*etiology
MH  - Vitamin D/*blood
MH  - Vitamin D Deficiency/blood/*complications
OTO - NOTNLM
OT  - 25(OH)D
OT  - allergens
OT  - asthma
OT  - therapeutics
OT  - vitamin D
EDAT- 2014/09/02 06:00
MHDA- 2015/09/01 06:00
CRDT- 2014/09/02 06:00
PHST- 2014/02/04 00:00 [received]
PHST- 2014/06/04 00:00 [revised]
PHST- 2014/07/08 00:00 [accepted]
PHST- 2014/09/02 06:00 [entrez]
PHST- 2014/09/02 06:00 [pubmed]
PHST- 2015/09/01 06:00 [medline]
AID - 10.1002/alr.21401 [doi]
PST - ppublish
SO  - Int Forum Allergy Rhinol. 2014 Dec;4(12):980-5. doi: 10.1002/alr.21401. Epub 2014 
      Aug 31.