PMID- 25176587
OWN - NLM
STAT- MEDLINE
DCOM- 20151215
LR  - 20220408
IS  - 2210-741X (Electronic)
IS  - 2210-7401 (Linking)
VI  - 39
IP  - 1
DP  - 2015 Feb
TI  - HER2/neu over-expression predicts poor outcome in early gastric cancer without 
      lymph node metastasis.
PG  - 121-6
LID - S2210-7401(14)00180-6 [pii]
LID - 10.1016/j.clinre.2014.06.019 [doi]
AB  - PURPOSE: Human epidermal growth factor receptor 2 (HER2/neu) is involved in the 
      pathogenesis of several types of cancer, including gastric cancer. However, there 
      remains a paucity of data regarding the prognostic relevance of HER2/neu in early 
      gastric cancer without lymph node metastasis (pN0 EGC). The aim of our study was 
      to analyze whether the over-expression of HER2/neu significantly predicts poor 
      outcomes of pN0 EGC. PATIENTS AND METHODS: Sixty-seven patients who underwent 
      operative resection for pN0 EGC was enrolled. The HER2/neu status was examined by 
      immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). 
      RESULTS: The HER2/neu-positive rate was 16.4%. HER2/neu over-expression showed a 
      significant correlation with histological type (P </= 0.001), tumor location 
      (P=0.022) and Lauren grade (P=0.012). Multivariate analysis showed HER2/neu 
      serves as a good prognostic marker to predict the risk of poor outcome for pN0 
      EGC. (HR=1.384, 95.0% CI: 1.142-1.897 P=0.005) CONCLUSION: Considering HER2/neu 
      over-expression significantly predicts poor outcome in pN0 EGC, accurate HER2/neu 
      assessment would be done before endoscopic therapy. For HER2/neu-positive 
      patients, radical surgery should be performed.
CI  - Copyright (c) 2014 Elsevier Masson SAS. All rights reserved.
FAU - Yan, Yongjia
AU  - Yan Y
AD  - Department of General Surgery, Tianjin Medical University General Hospital, 
      Tianjin 300052, China.
FAU - Lu, Li
AU  - Lu L
AD  - Tianjin Medical University, Tianjin 300070, China.
FAU - Liu, Chunna
AU  - Liu C
AD  - Tianjin Medical University, Tianjin 300070, China.
FAU - Li, Weidong
AU  - Li W
AD  - Department of General Surgery, Tianjin Medical University General Hospital, 
      Tianjin 300052, China.
FAU - Liu, Tong
AU  - Liu T
AD  - Department of General Surgery, Tianjin Medical University General Hospital, 
      Tianjin 300052, China.
FAU - Fu, Weihua
AU  - Fu W
AD  - Department of General Surgery, Tianjin Medical University General Hospital, 
      Tianjin 300052, China. Electronic address: drfuweihua@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20140828
PL  - France
TA  - Clin Res Hepatol Gastroenterol
JT  - Clinics and research in hepatology and gastroenterology
JID - 101553659
RN  - EC 2.7.10.1 (ERBB2 protein, human)
RN  - EC 2.7.10.1 (Receptor, ErbB-2)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Receptor, ErbB-2/*biosynthesis
MH  - Stomach Neoplasms/*metabolism/surgery
EDAT- 2014/09/02 06:00
MHDA- 2015/12/17 06:00
CRDT- 2014/09/02 06:00
PHST- 2014/03/03 00:00 [received]
PHST- 2014/06/08 00:00 [revised]
PHST- 2014/06/13 00:00 [accepted]
PHST- 2014/09/02 06:00 [entrez]
PHST- 2014/09/02 06:00 [pubmed]
PHST- 2015/12/17 06:00 [medline]
AID - S2210-7401(14)00180-6 [pii]
AID - 10.1016/j.clinre.2014.06.019 [doi]
PST - ppublish
SO  - Clin Res Hepatol Gastroenterol. 2015 Feb;39(1):121-6. doi: 
      10.1016/j.clinre.2014.06.019. Epub 2014 Aug 28.