PMID- 25178896
OWN - NLM
STAT- MEDLINE
DCOM- 20151204
LR  - 20211021
IS  - 1432-1076 (Electronic)
IS  - 0340-6199 (Linking)
VI  - 174
IP  - 3
DP  - 2015 Mar
TI  - Low serum 25-hydroxyvitamin D levels and bronchiolitis severity in Spanish 
      infants.
PG  - 365-72
LID - 10.1007/s00431-014-2405-4 [doi]
AB  - This cross-sectional study was performed to examine the prevalence of 
      hypovitaminosis D in infants with acute bronchiolitis compared with control 
      subjects and to evaluate the relationship between serum 25-hydroxyvitamin D 
      (25(OH) D) and the severity of bronchiolitis. Serum 25(OH) D levels were measured 
      by radioimmunoassay in 48 infants with acute bronchiolitis (2.5 +/- 2.0 months) and 
      in 30 healthy infants (3.2 +/- 2.3 months). 25(OH) D levels (ng/ml) in children 
      with acute bronchiolitis were significantly lower than in the control group 
      (median 29.9 ng/ml (interquartile range (IQR) 21.4-37.5) versus median 38.2 ng/ml 
      ((IQR 26.1-48.1), p = 0.022), mainly in infants with moderate-severe 
      bronchiolitis (median 29.8 ng/ml, IQR 19.2-35.9). The prevalence of 
      hypovitaminosis D was remarkably greater among infants with bronchiolitis than in 
      control subjects (52.1 versus 26.6%). A significant inverse correlation was found 
      between serum 25-hydroxyvitamin D levels and disease severity (rho = -0.457, 
      p < 0.001). CONCLUSION: The prevalence of hypovitaminosis D is high in Spanish 
      infants with bronchiolitis. The severity of acute bronchiolitis increases with a 
      decline in serum 25 (OH) D level.
FAU - Moreno-Solis, Gloria
AU  - Moreno-Solis G
AD  - Reina Sofia Children's Hospital, Avda Menendez Pidal S/N, 14004, Cordoba, Spain, 
      gloriamorenosolis@gmail.com.
FAU - Fernandez-Gutierrez, Fernando
AU  - Fernandez-Gutierrez F
FAU - Torres-Borrego, Javier
AU  - Torres-Borrego J
FAU - Torcello-Gaspar, Ricardo
AU  - Torcello-Gaspar R
FAU - Gomez-Chaparro Moreno, Jose Luis
AU  - Gomez-Chaparro Moreno JL
FAU - Perez-Navero, Juan Luis
AU  - Perez-Navero JL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140902
PL  - Germany
TA  - Eur J Pediatr
JT  - European journal of pediatrics
JID - 7603873
RN  - 1406-16-2 (Vitamin D)
RN  - A288AR3C9H (25-hydroxyvitamin D)
SB  - IM
MH  - Acute Disease
MH  - Bronchiolitis/blood/*epidemiology/*physiopathology
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Infant
MH  - Male
MH  - Prevalence
MH  - Severity of Illness Index
MH  - Spain/epidemiology
MH  - Vitamin D/*analogs & derivatives/blood
MH  - Vitamin D Deficiency/blood/*epidemiology
EDAT- 2014/09/03 06:00
MHDA- 2015/12/15 06:00
CRDT- 2014/09/03 06:00
PHST- 2014/03/24 00:00 [received]
PHST- 2014/08/19 00:00 [accepted]
PHST- 2014/08/12 00:00 [revised]
PHST- 2014/09/03 06:00 [entrez]
PHST- 2014/09/03 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
AID - 10.1007/s00431-014-2405-4 [doi]
PST - ppublish
SO  - Eur J Pediatr. 2015 Mar;174(3):365-72. doi: 10.1007/s00431-014-2405-4. Epub 2014 
      Sep 2.