PMID- 25179125
OWN - NLM
STAT- MEDLINE
DCOM- 20150406
LR  - 20211021
IS  - 1744-9081 (Electronic)
IS  - 1744-9081 (Linking)
VI  - 10
DP  - 2014 Sep 1
TI  - Age-dependent effect of high cholesterol diets on anxiety-like behavior in 
      elevated plus maze test in rats.
PG  - 30
LID - 10.1186/1744-9081-10-30 [doi]
AB  - BACKGROUND: Cholesterol is an essential component of brain and nerve cells and is 
      essential for maintaining the function of the nervous system. Epidemiological 
      studies showed that patients suffering from anxiety disorders have higher serum 
      cholesterol levels. In this study, we investigated the influence of high 
      cholesterol diet on anxiety-like behavior in elevated plus maze in animal model 
      and explored the relationship between cholesterol and anxiety-like behavior from 
      the aspect of central neurochemical changes. METHODS: Young (3 weeks old) and 
      adult (20 weeks old) rats were given a high cholesterol diet for 8 weeks. The 
      anxiety-like behavior in elevated plus maze test and changes of central 
      neurochemical implicated in anxiety were measured. RESULTS: In young rats, high 
      cholesterol diet induced anxiolytic-like behavior, decreased serum corticosterone 
      (CORT), increased hippocampal brain-derived neurotrophic factor (BDNF), increased 
      hippocampal mineralocorticoid receptor (MR) and decreased glucocorticoid receptor 
      (GR). In adult rats, high cholesterol diet induced anxiety-like behavior and 
      increase of serum CORT and decrease of hippocampal BDNF comparing with their 
      respective control group that fed the regular diet. DISCUSSION: High cholesterol 
      diet induced age-dependent effects on anxiety-like behavior and central 
      neurochemical changes. High cholesterol diet might affect the central nervous 
      system (CNS) function differently, and resulting in different behavior 
      performance of anxiety in different age period.
FAU - Hu, Xu
AU  - Hu X
FAU - Wang, Tao
AU  - Wang T
FAU - Luo, Jia
AU  - Luo J
FAU - Liang, Shan
AU  - Liang S
FAU - Li, Wei
AU  - Li W
FAU - Wu, Xiaoli
AU  - Wu X
FAU - Jin, Feng
AU  - Jin F
AD  - Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of 
      Sciences, Beijing, China. jinfeng@psych.ac.cn.
FAU - Wang, Li
AU  - Wang L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140901
PL  - England
TA  - Behav Brain Funct
JT  - Behavioral and brain functions : BBF
JID - 101245751
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cholesterol, Dietary)
RN  - 0 (Neurotransmitter Agents)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Aging/*psychology
MH  - Animals
MH  - Anxiety/*psychology
MH  - Brain Chemistry/physiology
MH  - Brain-Derived Neurotrophic Factor/blood
MH  - Cholesterol, Dietary/*adverse effects
MH  - Diet
MH  - Hippocampus/metabolism
MH  - Hydrocortisone/blood
MH  - Male
MH  - Motor Activity/drug effects
MH  - Neurotransmitter Agents/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
PMC - PMC4158000
EDAT- 2014/09/03 06:00
MHDA- 2015/04/07 06:00
PMCR- 2014/09/01
CRDT- 2014/09/03 06:00
PHST- 2014/05/16 00:00 [received]
PHST- 2014/08/25 00:00 [accepted]
PHST- 2014/09/03 06:00 [entrez]
PHST- 2014/09/03 06:00 [pubmed]
PHST- 2015/04/07 06:00 [medline]
PHST- 2014/09/01 00:00 [pmc-release]
AID - 1744-9081-10-30 [pii]
AID - 10.1186/1744-9081-10-30 [doi]
PST - epublish
SO  - Behav Brain Funct. 2014 Sep 1;10:30. doi: 10.1186/1744-9081-10-30.