PMID- 25179346
OWN - NLM
STAT- MEDLINE
DCOM- 20150408
LR  - 20150211
IS  - 1362-3095 (Electronic)
IS  - 0955-3002 (Linking)
VI  - 91
IP  - 2
DP  - 2015 Feb
TI  - Ablation of experimental colon cancer by intratumoral 224Radium-loaded wires is 
      mediated by alpha particles released from atoms which spread in the tumor and can 
      be augmented by chemotherapy.
PG  - 179-86
LID - 10.3109/09553002.2015.959666 [doi]
AB  - PURPOSE: We developed (224)Ra-loaded wires, which release by recoil alpha 
      emitting nuclei into solid tumors and cause tumor cell killing. This research 
      examined if the major damage was inflicted by alpha particles emitted from these 
      atoms or by direct gamma and beta emissions from the inserted wires. We also 
      examined the efficacy of this treatment against colon cancer in combination with 
      chemotherapy. MATERIALS AND METHODS: Mouse colon carcinomas (CT-26 xenografts), 
      treated by intra-tumoral radioactive wires loaded with (224)Ra atoms were 
      monitored for effects on tumor growth, intratumoral tissue damage and 
      distribution of alpha emitting atoms. The effects were compared with those of 
      (224)Ra-loaded wires coated with poly methyl methacrylate (PMMA), which blocks 
      atom recoil. Similar experiments were performed with radioactive wires combined 
      with systemic 5-FU. RESULTS: (224)Ra-loaded wires inhibited tumor growth and 
      formed necrotic areas inside the tumor. PMMA coated wires did not inhibit tumor 
      growth, and caused minor intratumoral damage. Autoradiography images of tumors 
      treated with (224)Ra-loaded wires revealed a spread of alpha emitters over 
      several mm, whereas PMMA-coated wires showed no such spread. Injection of 5-FU 
      with (224)Ra-loaded wires augmented tumor growth retardation and cure. 
      CONCLUSIONS: (224)Ra-loaded wires ablate solid tumors by the release of 
      alpha-particle emitting atoms inside the tissue, an effect that can be enhanced 
      by combining this method with chemotherapy.
FAU - Reitkopf-Brodutch, Shira
AU  - Reitkopf-Brodutch S
AD  - Department of Clinical Microbiology and Immunology, Sackler Faculty of Medicine, 
      Tel Aviv University , Tel Aviv , Israel.
FAU - Confino, Hila
AU  - Confino H
FAU - Schmidt, Michael
AU  - Schmidt M
FAU - Cooks, Tomer
AU  - Cooks T
FAU - Efrati, Margalit
AU  - Efrati M
FAU - Arazi, Lior
AU  - Arazi L
FAU - Rath-Wolfson, Lea
AU  - Rath-Wolfson L
FAU - Marshak, Gideon
AU  - Marshak G
FAU - Kelson, Itzhak
AU  - Kelson I
FAU - Keisari, Yona
AU  - Keisari Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150129
PL  - England
TA  - Int J Radiat Biol
JT  - International journal of radiation biology
JID - 8809243
RN  - 0 (Antineoplastic Agents)
RN  - U3P01618RT (Fluorouracil)
RN  - W90AYD6R3Q (Radium)
SB  - IM
MH  - Ablation Techniques/*instrumentation
MH  - Alpha Particles/*therapeutic use
MH  - Animals
MH  - Antineoplastic Agents/*pharmacology/therapeutic use
MH  - Brachytherapy/*instrumentation
MH  - Cell Line, Tumor
MH  - Colonic Neoplasms/drug therapy/*pathology/surgery/*therapy
MH  - Combined Modality Therapy
MH  - Disease Models, Animal
MH  - Fluorouracil/pharmacology/therapeutic use
MH  - Humans
MH  - Male
MH  - Mice
MH  - Radium/*therapeutic use
OTO - NOTNLM
OT  - 224Ra
OT  - 5-FU
OT  - Colon cancer
OT  - brachytherapy
OT  - chemotherapy
OT  - radiotherapy
EDAT- 2014/09/03 06:00
MHDA- 2015/04/09 06:00
CRDT- 2014/09/03 06:00
PHST- 2014/09/03 06:00 [entrez]
PHST- 2014/09/03 06:00 [pubmed]
PHST- 2015/04/09 06:00 [medline]
AID - 10.3109/09553002.2015.959666 [doi]
PST - ppublish
SO  - Int J Radiat Biol. 2015 Feb;91(2):179-86. doi: 10.3109/09553002.2015.959666. Epub 
      2015 Jan 29.