PMID- 25180067
OWN - NLM
STAT- MEDLINE
DCOM- 20150330
LR  - 20211021
IS  - 1942-0994 (Electronic)
IS  - 1942-0900 (Print)
IS  - 1942-0994 (Linking)
VI  - 2014
DP  - 2014
TI  - The effects of sesquiterpenes-rich extract of Alpinia oxyphylla Miq. on 
      amyloid-beta-induced cognitive impairment and neuronal abnormalities in the cortex 
      and hippocampus of mice.
PG  - 451802
LID - 10.1155/2014/451802 [doi]
LID - 451802
AB  - As a kind of medicine which can also be used as food, Alpinia oxyphylla Miq. has 
      a long clinical history in China. A variety of studies demonstrated the 
      significant neuroprotective activity effects of chloroform (CF) extract from the 
      fruits of Alpinia oxyphylla. In order to further elucidate the possible 
      mechanisms of CF extract which mainly contains sesquiterpenes with 
      neuroprotection on the cognitive ability, mice were injected with Abeta(1-42) and 
      later with CF in this study. The results showed that the long-term treatment of 
      CF enhanced the cognitive performances in behavior tests, increased activities of 
      glutathione peroxidase (GSH-px) and decreased the level of malondialdehyde (MDA), 
      acetylcholinesterase (AChE), and amyloid-beta (Abeta), and reversed the activation of 
      microglia, degeneration of neuronal acidophilia, and nuclear condensation in the 
      cortex and hippocampus. These results demonstrate that CF ameliorates learning 
      and memory deficits by attenuating oxidative stress and regulating the activation 
      of microglia and degeneration of neuronal acidophilia to reinforce cholinergic 
      functions.
FAU - Shi, Shao-Huai
AU  - Shi SH
AD  - Shenyang Key Laboratory of Active Components of Traditional Chinese Medicine 
      Screening and Evaluation, School of Traditional Chinese Materia Medica, Shenyang 
      Pharmaceutical University, Wenhua Road 103, Shenyang 110016, China.
FAU - Zhao, Xu
AU  - Zhao X
AD  - Shenyang Key Laboratory of Active Components of Traditional Chinese Medicine 
      Screening and Evaluation, School of Traditional Chinese Materia Medica, Shenyang 
      Pharmaceutical University, Wenhua Road 103, Shenyang 110016, China.
FAU - Liu, Bing
AU  - Liu B
AD  - Shenyang Key Laboratory of Active Components of Traditional Chinese Medicine 
      Screening and Evaluation, School of Traditional Chinese Materia Medica, Shenyang 
      Pharmaceutical University, Wenhua Road 103, Shenyang 110016, China.
FAU - Li, Huan
AU  - Li H
AD  - Shenyang Key Laboratory of Active Components of Traditional Chinese Medicine 
      Screening and Evaluation, School of Traditional Chinese Materia Medica, Shenyang 
      Pharmaceutical University, Wenhua Road 103, Shenyang 110016, China.
FAU - Liu, Ai-Jing
AU  - Liu AJ
AD  - Shenyang Key Laboratory of Active Components of Traditional Chinese Medicine 
      Screening and Evaluation, School of Traditional Chinese Materia Medica, Shenyang 
      Pharmaceutical University, Wenhua Road 103, Shenyang 110016, China.
FAU - Wu, Bo
AU  - Wu B
AD  - Shenyang Key Laboratory of Active Components of Traditional Chinese Medicine 
      Screening and Evaluation, School of Traditional Chinese Materia Medica, Shenyang 
      Pharmaceutical University, Wenhua Road 103, Shenyang 110016, China.
FAU - Bi, Kai-Shun
AU  - Bi KS
AD  - The Engineering Laboratory of National and Local Union of Quality Control for 
      Traditional Chinese Medicine, School of Pharmacy, Shenyang Pharmaceutical 
      University, Wenhua Road 103, Shenyang 110016, China.
FAU - Jia, Ying
AU  - Jia Y
AUID- ORCID: 0000-0002-1289-4350
AD  - Shenyang Key Laboratory of Active Components of Traditional Chinese Medicine 
      Screening and Evaluation, School of Traditional Chinese Materia Medica, Shenyang 
      Pharmaceutical University, Wenhua Road 103, Shenyang 110016, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140807
PL  - United States
TA  - Oxid Med Cell Longev
JT  - Oxidative medicine and cellular longevity
JID - 101479826
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Peptide Fragments)
RN  - 0 (Plant Extracts)
RN  - 0 (Sesquiterpenes)
RN  - 0 (amyloid beta-protein (1-42))
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 3.1.1.7 (Acetylcholinesterase)
RN  - EC 3.4.- (Amyloid Precursor Protein Secretases)
SB  - IM
MH  - Acetylcholinesterase/metabolism
MH  - Alpinia/*chemistry/metabolism
MH  - Amyloid Precursor Protein Secretases/metabolism
MH  - Amyloid beta-Peptides/toxicity
MH  - Animals
MH  - Behavior, Animal/drug effects
MH  - Cerebral Cortex/*drug effects/metabolism/pathology
MH  - Chromatography, High Pressure Liquid
MH  - Cognition Disorders/chemically induced/drug therapy/physiopathology
MH  - Glutathione Peroxidase/metabolism
MH  - Hippocampus/*drug effects/metabolism/pathology
MH  - Male
MH  - Malondialdehyde/metabolism
MH  - Maze Learning/drug effects
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Peptide Fragments/toxicity
MH  - Plant Extracts/analysis/chemistry
MH  - Sesquiterpenes/chemistry/*pharmacology/therapeutic use
MH  - Spectrometry, Mass, Electrospray Ionization
PMC - PMC4142297
EDAT- 2014/09/03 06:00
MHDA- 2015/03/31 06:00
PMCR- 2014/08/07
CRDT- 2014/09/03 06:00
PHST- 2014/02/25 00:00 [received]
PHST- 2014/07/10 00:00 [accepted]
PHST- 2014/09/03 06:00 [entrez]
PHST- 2014/09/03 06:00 [pubmed]
PHST- 2015/03/31 06:00 [medline]
PHST- 2014/08/07 00:00 [pmc-release]
AID - 10.1155/2014/451802 [doi]
PST - ppublish
SO  - Oxid Med Cell Longev. 2014;2014:451802. doi: 10.1155/2014/451802. Epub 2014 Aug 
      7.