PMID- 25182985
OWN - NLM
STAT- MEDLINE
DCOM- 20141222
LR  - 20140903
IS  - 1001-9391 (Print)
IS  - 1001-9391 (Linking)
VI  - 32
IP  - 8
DP  - 2014 Aug
TI  - [Relationship between genetic polymorphisms of matrix metalloproteinase-2 and -3 
      and susceptibility to silicosis].
PG  - 573-7
AB  - OBJECTIVE: To investigate the relationship between the genetic polymorphisms of 
      matrix metalloproteinase-2 (MMP-2) (-735) and matrix metalloproteinase-3 (MMP-3) 
      (-1171) and the susceptibility to silicosis. METHODS: A case-control study was 
      conducted in 113 patients diagnosed with stage I silicosis (case group) and 115 
      dust-exposed workers without silicosis (control group); the two groups had the 
      same sex, ethnic group, and type of dust and similar age and cumulative exposure 
      time. Polymerase chain reaction-restriction fragment length polymorphism was used 
      to determine the genotypes of MMP-2 (-735) and MMP-3 (-1171). RESULTS: No 
      significant difference was observed in age, cumulative exposure time, or smoking 
      rate between cases and controls (P > 0.05). The frequencies of genotypes C/C, 
      C/T, and T/T at MMP-2 C-735T in the case group were 57.5% (65/113), 31.0% 
      (35/113), and 11.5% (13/113), respectively, which were significantly different 
      from those of the control group (69.6% (80/115), 26.9% (31/115), and 3.5% 
      (4/115)), chi(2) = 6.542, P < 0.05). The frequencies of T allele in cases and 
      controls were 27.0% and 17.0%, respectively, which were significantly different 
      from each other chi(2) = 6.704, P < 0.05). Carriage of T allele at MMP-2 C-735T 
      increased the risk of silicosis (OR = 1.811, 95% CI: 1.151-2.847). The 
      frequencies of genotypes 6A/6A, 5A/6A, and 5A/5A at MMP-3 A-1171A were 67.2% 
      (76/113), 24.8% (28/113), and 8.0% (9/113), respectively, in the case group, 
      versus 59.1% (68/115), 37.4% (43/115), and 3.5% (4/115) in the control group (chi(2) 
      = 5.519, P > 0.05). CONCLUSION: Genetic polymorphism at MMP-2 C-735T is 
      significantly associated with the development of silicosis. Carriage of T allele 
      increases the risk of silicosis among workers exposed to dust. No significant 
      association was found between MMP-3 A-1171A polymorphism and silicosis in this 
      study.
FAU - Kou, Jie
AU  - Kou J
AD  - School of Public Health, Hebei United University, Tangshan, Hebei Province 
      063000, China.
FAU - Fan, Xueyun
AU  - Fan X
AD  - School of Public Health, Hebei United University, Tangshan, Hebei Province 
      063000, China. E-mail: xueyun53@163.com.
FAU - Shi, Yaxin
AU  - Shi Y
AD  - School of Public Health, Hebei United University, Tangshan, Hebei Province 
      063000, China.
FAU - Wang, Xiaoyan
AU  - Wang X
AD  - School of Public Health, Hebei United University, Tangshan, Hebei Province 
      063000, China.
FAU - Shen, Fuhai
AU  - Shen F
AD  - School of Public Health, Hebei United University, Tangshan, Hebei Province 
      063000, China.
FAU - Jin, Yulan
AU  - Jin Y
AD  - School of Public Health, Hebei United University, Tangshan, Hebei Province 
      063000, China. E-mail: yulanjin225@qq.com.
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
JT  - Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng 
      zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases
JID - 8410840
RN  - EC 3.4.24.17 (MMP3 protein, human)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
RN  - EC 3.4.24.24 (MMP2 protein, human)
RN  - EC 3.4.24.24 (Matrix Metalloproteinase 2)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Case-Control Studies
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Matrix Metalloproteinase 2/*genetics
MH  - Matrix Metalloproteinase 3/*genetics
MH  - Middle Aged
MH  - *Polymorphism, Genetic
MH  - Silicosis/*genetics
EDAT- 2014/09/04 06:00
MHDA- 2014/12/23 06:00
CRDT- 2014/09/04 06:00
PHST- 2014/09/04 06:00 [entrez]
PHST- 2014/09/04 06:00 [pubmed]
PHST- 2014/12/23 06:00 [medline]
PST - ppublish
SO  - Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2014 Aug;32(8):573-7.