PMID- 25183693
OWN - NLM
STAT- MEDLINE
DCOM- 20150817
LR  - 20211021
IS  - 1469-994X (Electronic)
IS  - 1462-2203 (Print)
IS  - 1462-2203 (Linking)
VI  - 17
IP  - 3
DP  - 2015 Mar
TI  - Association between smoking, nicotine dependence, and BDNF Val66Met polymorphism 
      with BDNF concentrations in serum.
PG  - 323-9
LID - 10.1093/ntr/ntu151 [doi]
AB  - INTRODUCTION: Nicotine use is associated with the upregulation of brain-derived 
      neurotrophic factor (BDNF) in serum. An association between smoking and the BDNF 
      Val(66)Met polymorphism has also been found. The aim of this study is to examine 
      the levels of serum BDNF in never-smokers, former smokers, and current 
      smokers-with and without nicotine dependence-and to examine the interaction of 
      the polymorphism and smoking status with serum BDNF. METHODS: We used baseline 
      serum and gene data of BDNF on 2,088 participants from the Netherlands Study of 
      Depression and Anxiety (NESDA) to investigate smoking-BDNF association while 
      controlling for potential confounding variables. Nicotine dependence was assessed 
      with the Fagerstrom Test for Nicotine Dependence (FTND). RESULTS: Smokers with 
      and without nicotine dependence had higher levels of serum BDNF than former and 
      never-smokers. Nicotine dependence and number of cigarettes smoked per day did 
      not add to the prediction of serum BDNF; however, total number of smoking years 
      was a significant predictor of serum BDNF. There was no association of BDNF 
      Val(66)Met, nor an interaction of this polymorphism and smoking status, with 
      serum BDNF. CONCLUSIONS: Current smoking and higher number of smoking years are 
      associated with higher levels of serum BDNF, and this is independent of the BDNF 
      genotype. Nicotine dependence itself is not associated with a further increase or 
      decrease of serum BDNF. Longitudinal investigations that address changes in serum 
      BDNF in incident smokers and/or in quitters may be useful to understand the 
      association of smoking with BDNF.
CI  - (c) The Author 2014. Published by Oxford University Press on behalf of the Society 
      for Research on Nicotine and Tobacco. All rights reserved. For permissions, 
      please e-mail: journals.permissions@oup.com.
FAU - Jamal, Mumtaz
AU  - Jamal M
AD  - Institute of Psychology, Leiden University, Leiden, The Netherlands; 
      mjamal@fsw.leidenuniv.nl.
FAU - Van der Does, Willem
AU  - Van der Does W
AD  - Institute of Psychology, Leiden University, Leiden, The Netherlands; Department 
      of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands;
FAU - Elzinga, Bernet M
AU  - Elzinga BM
AD  - Institute of Psychology, Leiden University, Leiden, The Netherlands;
FAU - Molendijk, Marc L
AU  - Molendijk ML
AD  - Institute of Psychology, Leiden University, Leiden, The Netherlands;
FAU - Penninx, Brenda W J H
AU  - Penninx BW
AD  - Department of Psychiatry, Leiden University Medical Center, Leiden, The 
      Netherlands;
LA  - eng
GR  - MH081802/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20140902
PL  - England
TA  - Nicotine Tob Res
JT  - Nicotine & tobacco research : official journal of the Society for Research on 
      Nicotine and Tobacco
JID - 9815751
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*blood/*genetics
MH  - Cohort Studies
MH  - Cross-Sectional Studies
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Methionine/genetics
MH  - Middle Aged
MH  - Netherlands/epidemiology
MH  - Polymorphism, Genetic/*genetics
MH  - Prospective Studies
MH  - Smoking/epidemiology/*genetics/metabolism
MH  - Tobacco Use Disorder/*blood/epidemiology/*genetics
MH  - Valine/genetics
PMC - PMC4837993
EDAT- 2014/09/04 06:00
MHDA- 2015/08/19 06:00
PMCR- 2016/03/01
CRDT- 2014/09/04 06:00
PHST- 2014/09/04 06:00 [entrez]
PHST- 2014/09/04 06:00 [pubmed]
PHST- 2015/08/19 06:00 [medline]
PHST- 2016/03/01 00:00 [pmc-release]
AID - ntu151 [pii]
AID - 10.1093/ntr/ntu151 [doi]
PST - ppublish
SO  - Nicotine Tob Res. 2015 Mar;17(3):323-9. doi: 10.1093/ntr/ntu151. Epub 2014 Sep 2.