PMID- 2518372
OWN - NLM
STAT- MEDLINE
DCOM- 19901019
LR  - 20190820
IS  - 0896-6273 (Print)
IS  - 0896-6273 (Linking)
VI  - 3
IP  - 6
DP  - 1989 Dec
TI  - The regulation of amyloid beta protein precursor secretion and its modulatory 
      role in cell adhesion.
PG  - 689-94
AB  - The regulation and function of two forms of the amyloid beta protein precursor 
      (ABPP) that are released into the growth-conditioned medium of the PC12 nerve 
      cell line were examined. Nerve growth factor increases the release of the form of 
      ABPP without the protease-inhibitor domain relative to the protein containing the 
      protease inhibitor and increases the overall rate of ABPP secretion 2-fold. In 
      contrast, fibroblast growth factor increases the rate of ABPP secretion 
      approximately 7-fold. Both forms of the secreted ABPP molecule are, in turn, able 
      to stimulate adhesion of PC12 cells to substrata to which they are adsorbed about 
      10-fold more efficiently on a molar basis than Iaminin.
FAU - Schubert, D
AU  - Schubert D
AD  - Salk Institute For Biological Studies, San Diego, California 92138.
FAU - Jin, L W
AU  - Jin LW
FAU - Saitoh, T
AU  - Saitoh T
FAU - Cole, G
AU  - Cole G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Neuron
JT  - Neuron
JID - 8809320
RN  - 0 (Amyloid)
RN  - 0 (Amyloid beta-Protein Precursor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Protease Inhibitors)
RN  - 0 (Protein Precursors)
RN  - 62031-54-3 (Fibroblast Growth Factors)
SB  - IM
EIN - Neuron 1990 May;4(5):813
MH  - Amyloid/*metabolism/pharmacology/physiology
MH  - Amyloid beta-Protein Precursor
MH  - Animals
MH  - Cell Adhesion/drug effects/physiology
MH  - Cell Line
MH  - Fibroblast Growth Factors/pharmacology
MH  - Molecular Weight
MH  - Nerve Growth Factors/pharmacology
MH  - Neurons/metabolism/*physiology
MH  - Protease Inhibitors
MH  - Protein Precursors/*metabolism/pharmacology/physiology
EDAT- 1989/12/01 00:00
MHDA- 1989/12/01 00:01
CRDT- 1989/12/01 00:00
PHST- 1989/12/01 00:00 [pubmed]
PHST- 1989/12/01 00:01 [medline]
PHST- 1989/12/01 00:00 [entrez]
AID - 0896-6273(89)90237-7 [pii]
AID - 10.1016/0896-6273(89)90237-7 [doi]
PST - ppublish
SO  - Neuron. 1989 Dec;3(6):689-94. doi: 10.1016/0896-6273(89)90237-7.