PMID- 25184661
OWN - NLM
STAT- MEDLINE
DCOM- 20160515
LR  - 20181202
IS  - 2040-3372 (Electronic)
IS  - 2040-3364 (Linking)
VI  - 6
IP  - 21
DP  - 2014 Nov 7
TI  - PEGylated nickel carbide nanocrystals as efficient near-infrared laser induced 
      photothermal therapy for treatment of cancer cells in vivo.
PG  - 12591-600
LID - 10.1039/c4nr03727h [doi]
AB  - Photothermal therapy has attracted significant attention as a minimally invasive 
      therapy methodology. In this work, we report PEGylated nickel carbide 
      nanocrystals (Ni3C NCs) as an efficient photothermal agent for the first time. 
      The nanoparticles exhibit a broad absorption from the visible to the 
      near-infrared regions and a rapid rise in temperature when irradiated by an 808 
      nm laser even at a concentration of 100 mug mL(-1). In vitro and in vivo 
      cytotoxicity assays demonstrate they have good biocompatibility, which lays an 
      important foundation for their biological application. In vitro studies reveal 
      the efficient damage of cancer cells by the exposure of 808 nm laser with a power 
      density of 0.50 W cm(-2). Furthermore, hematoxylin and eosin (H & E) and terminal 
      deoxynucleotidyl transferase biotin-dUTP nick-end labeling (TUNEL) staining of 
      tumor slices confirmed the obvious destruction of cancer cells in vivo by an 808 
      nm laser (0.50 W cm(-2)) after only a 5 min application. Our work may open up a 
      new application domain for transition metal carbides for biomedicine.
FAU - Zhou, Zhiguo
AU  - Zhou Z
AD  - The Education Ministry Key Lab of Resource Chemistry and Shanghai Key Laboratory 
      of Rare Earth Functional Materials, Shanghai Normal University, Shanghai 200234, 
      China.
FAU - Wang, Jun
AU  - Wang J
FAU - Liu, Wei
AU  - Liu W
FAU - Yu, Chao
AU  - Yu C
FAU - Kong, Bin
AU  - Kong B
FAU - Sun, Yanan
AU  - Sun Y
FAU - Yang, Hong
AU  - Yang H
FAU - Yang, Shiping
AU  - Yang S
FAU - Wang, Wei
AU  - Wang W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nanoscale
JT  - Nanoscale
JID - 101525249
RN  - 0 (Biocompatible Materials)
RN  - 0 (Ligands)
RN  - 0 (Metals)
RN  - 0 (nickel carbide)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
RN  - 7440-44-0 (Carbon)
RN  - 7OV03QG267 (Nickel)
SB  - IM
MH  - Animals
MH  - Biocompatible Materials/chemistry
MH  - Carbon/*chemistry
MH  - HeLa Cells
MH  - Humans
MH  - In Situ Nick-End Labeling
MH  - *Lasers
MH  - Ligands
MH  - Metals/chemistry
MH  - Mice
MH  - Mice, Nude
MH  - Microscopy, Confocal
MH  - Nanoparticles/*chemistry
MH  - Neoplasm Transplantation
MH  - Neoplasms/drug therapy/*therapy
MH  - Nickel/*chemistry
MH  - Photochemistry
MH  - *Phototherapy
MH  - Polyethylene Glycols/*chemistry
MH  - Rats
MH  - *Spectroscopy, Near-Infrared
EDAT- 2014/09/04 06:00
MHDA- 2016/05/18 06:00
CRDT- 2014/09/04 06:00
PHST- 2014/09/04 06:00 [entrez]
PHST- 2014/09/04 06:00 [pubmed]
PHST- 2016/05/18 06:00 [medline]
AID - 10.1039/c4nr03727h [doi]
PST - ppublish
SO  - Nanoscale. 2014 Nov 7;6(21):12591-600. doi: 10.1039/c4nr03727h.