PMID- 25184808
OWN - NLM
STAT- MEDLINE
DCOM- 20150330
LR  - 20240117
IS  - 1532-429X (Electronic)
IS  - 1097-6647 (Print)
IS  - 1097-6647 (Linking)
VI  - 16
IP  - 1
DP  - 2014 Jul 25
TI  - Multi-contrast atherosclerosis characterization (MATCH) of carotid plaque with a 
      single 5-min scan: technical development and clinical feasibility.
PG  - 53
LID - 10.1186/s12968-014-0053-5 [doi]
AB  - BACKGROUND: Multi-contrast weighted imaging is a commonly used cardiovascular 
      magnetic resonance (CMR) protocol for characterization of carotid plaque 
      composition. However, this approach is limited in several aspects including low 
      slice resolution, long scan time, image mis-registration, and complex image 
      interpretation. In this work, a 3D CMR technique, named Multi-contrast 
      Atherosclerosis Characterization (MATCH), was developed to mitigate the above 
      limitations. METHODS: MATCH employs a 3D spoiled segmented fast low angle shot 
      readout to acquire data with three different contrast weightings in an 
      interleaved fashion. The inherently co-registered image sets, hyper T1-weighting, 
      gray blood, and T2-weighting, are used to detect intra-plaque hemorrhage (IPH), 
      calcification (CA), lipid-rich necrotic core (LRNC), and loose-matrix (LM). The 
      MATCH sequence was optimized by computer simulations and testing on four healthy 
      volunteers and then evaluated in a pilot study of six patients with carotid 
      plaque, using the conventional multi-contrast protocol as a reference. RESULTS: 
      On MATCH images, the major plaque components were easy to identify. Spatial 
      co-registration between the three image sets with MATCH was particularly helpful 
      for the reviewer to discern co-existent components in an image and appreciate 
      their spatial relation. Based on Cohen's kappa tests, moderate to excellent 
      agreement in the image-based or artery-based component detection between the two 
      protocols was obtained for LRNC, IPH, CA, and LM, respectively. Compared with the 
      conventional multi-contrast protocol, the MATCH protocol yield significantly 
      higher signal contrast ratio for IPH (3.1+/-1.3 vs. 0.4+/-0.3, p<0.001) and CA 
      (1.6+/-1.5 vs. 0.7+/-0.6, p=0.012) with respect to the vessel wall. CONCLUSIONS: To 
      the best of our knowledge, the proposed MATCH sequence is the first 3D CMR 
      technique that acquires spatially co-registered multi-contrast image sets in a 
      single scan for characterization of carotid plaque composition. Our pilot 
      clinical study suggests that the MATCH-based protocol may outperform the 
      conventional multi-contrast protocol in several respects. With further technical 
      improvements and large-scale clinical validation, MATCH has the potential to 
      become a CMR method for assessing the risk of plaque disruption in a clinical 
      workup.
FAU - Fan, Zhaoyang
AU  - Fan Z
FAU - Yu, Wei
AU  - Yu W
FAU - Xie, Yibin
AU  - Xie Y
FAU - Dong, Li
AU  - Dong L
FAU - Yang, Lixin
AU  - Yang L
FAU - Wang, Zhanhong
AU  - Wang Z
FAU - Conte, Antonio Hernandez
AU  - Conte AH
FAU - Bi, Xiaoming
AU  - Bi X
FAU - An, Jing
AU  - An J
FAU - Zhang, Tianjing
AU  - Zhang T
FAU - Laub, Gerhard
AU  - Laub G
FAU - Shah, Prediman Krishan
AU  - Shah PK
FAU - Zhang, Zhaoqi
AU  - Zhang Z
FAU - Li, Debiao
AU  - Li D
LA  - eng
GR  - R01 HL096119/HL/NHLBI NIH HHS/United States
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
DEP - 20140725
PL  - England
TA  - J Cardiovasc Magn Reson
JT  - Journal of cardiovascular magnetic resonance : official journal of the Society 
      for Cardiovascular Magnetic Resonance
JID - 9815616
RN  - 0 (Contrast Media)
SB  - IM
MH  - Aged
MH  - Algorithms
MH  - Carotid Arteries/*pathology
MH  - Carotid Stenosis/*diagnosis/pathology
MH  - Computer Simulation
MH  - *Contrast Media
MH  - Feasibility Studies
MH  - Fibrosis
MH  - Hemorrhage/diagnosis/pathology
MH  - Humans
MH  - Image Interpretation, Computer-Assisted/*methods
MH  - Imaging, Three-Dimensional
MH  - Magnetic Resonance Angiography/*methods
MH  - Male
MH  - Middle Aged
MH  - Models, Cardiovascular
MH  - Necrosis
MH  - Pilot Projects
MH  - *Plaque, Atherosclerotic
MH  - Predictive Value of Tests
MH  - Reproducibility of Results
MH  - Signal-To-Noise Ratio
MH  - Vascular Calcification/diagnosis/pathology
PMC - PMC4222690
EDAT- 2014/09/04 06:00
MHDA- 2015/03/31 06:00
PMCR- 2014/07/25
CRDT- 2014/09/04 06:00
PHST- 2014/03/14 00:00 [received]
PHST- 2014/07/08 00:00 [accepted]
PHST- 2014/09/04 06:00 [entrez]
PHST- 2014/09/04 06:00 [pubmed]
PHST- 2015/03/31 06:00 [medline]
PHST- 2014/07/25 00:00 [pmc-release]
AID - S1097-6647(23)00120-5 [pii]
AID - s12968-014-0053-5 [pii]
AID - 10.1186/s12968-014-0053-5 [doi]
PST - epublish
SO  - J Cardiovasc Magn Reson. 2014 Jul 25;16(1):53. doi: 10.1186/s12968-014-0053-5.