PMID- 25184950
OWN - NLM
STAT- MEDLINE
DCOM- 20150514
LR  - 20211021
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 15
IP  - 9
DP  - 2014 Sep 2
TI  - Resveratrol induces the expression of interleukin-10 and brain-derived 
      neurotrophic factor in BV2 microglia under hypoxia.
PG  - 15512-29
LID - 10.3390/ijms150915512 [doi]
AB  - Microglia are the resident macrophages of the central nervous system (CNS) and 
      play an important role in neuronal recovery by scavenging damaged neurons. 
      However, overactivation of microglia leads to neuronal death that is associated 
      with CNS disorders. Therefore, regulation of microglial activation has been 
      suggested to be an important target for treatment of CNS diseases. In the present 
      study, we investigated the beneficial effect of resveratrol, a natural phenol 
      with antioxidant effects, in the microglial cell line, BV2, in a model of hypoxia 
      injury. Resveratrol suppressed the mRNA expression of the pro-inflammatory 
      molecule, tumor necrosis factor-alpha, and promoted the mRNA expression of the 
      anti-inflammatory molecule, interleukin-10, in BV2 microglia under hypoxic 
      conditions. In addition, resveratrol inhibited the activation of the 
      transcription factor, nuclear factor kappa-light-chain enhancer of activated B 
      cells (NF-kappaB), which is upstream in the control of inflammatory reactions in 
      hypoxia-injured BV2 microglia. Moreover, resveratrol promoted the expression of 
      brain-derived neurotrophic factor (BDNF) in BV2 microglia under hypoxic stress. 
      Overall, resveratrol may promote the beneficial function of microglia in ischemic 
      brain injury.
FAU - Song, Juhyun
AU  - Song J
AD  - Department of Anatomy, Yonsei University College of Medicine, Seoul 120-752, 
      Korea. sjh1008@yuhs.ac.
FAU - Cheon, So Yeong
AU  - Cheon SY
AD  - Department of Anatomy, Yonsei University College of Medicine, Seoul 120-752, 
      Korea. rigel110@hanmail.net.
FAU - Jung, Wonsug
AU  - Jung W
AD  - Department of Anatomy, Gachon University School of Medicine, Incheon 406-799, 
      Korea. wonsug@gmail.com.
FAU - Lee, Won Taek
AU  - Lee WT
AD  - Department of Anatomy, Yonsei University College of Medicine, Seoul 120-752, 
      Korea. inskull@yuhs.ac.
FAU - Lee, Jong Eun
AU  - Lee JE
AD  - Department of Anatomy, Yonsei University College of Medicine, Seoul 120-752, 
      Korea. jelee@yuhs.ac.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140902
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Antioxidants)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (NF-kappa B)
RN  - 0 (RNA, Messenger)
RN  - 0 (Stilbenes)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 130068-27-8 (Interleukin-10)
RN  - Q369O8926L (Resveratrol)
SB  - IM
MH  - Animals
MH  - Antioxidants/*pharmacology
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Cell Hypoxia
MH  - Cell Line
MH  - Interleukin-10/genetics/*metabolism
MH  - Mice
MH  - Microglia/*drug effects/metabolism
MH  - NF-kappa B/genetics/metabolism
MH  - RNA, Messenger/genetics/metabolism
MH  - Resveratrol
MH  - Stilbenes/*pharmacology
MH  - Tumor Necrosis Factor-alpha/genetics/metabolism
PMC - PMC4200860
EDAT- 2014/09/04 06:00
MHDA- 2015/05/15 06:00
PMCR- 2014/09/01
CRDT- 2014/09/04 06:00
PHST- 2014/05/15 00:00 [received]
PHST- 2014/08/08 00:00 [revised]
PHST- 2014/08/26 00:00 [accepted]
PHST- 2014/09/04 06:00 [entrez]
PHST- 2014/09/04 06:00 [pubmed]
PHST- 2015/05/15 06:00 [medline]
PHST- 2014/09/01 00:00 [pmc-release]
AID - ijms150915512 [pii]
AID - ijms-15-15512 [pii]
AID - 10.3390/ijms150915512 [doi]
PST - epublish
SO  - Int J Mol Sci. 2014 Sep 2;15(9):15512-29. doi: 10.3390/ijms150915512.