PMID- 25185411
OWN - NLM
STAT- MEDLINE
DCOM- 20141006
LR  - 20191113
IS  - 1433-6510 (Print)
IS  - 1433-6510 (Linking)
VI  - 60
IP  - 8
DP  - 2014
TI  - Association of rs7903146, rs12255372, and rs290487 polymorphisms in TCF7L2 gene 
      with type 2 diabetes in an Iranian Kurdish ethnic group.
PG  - 1269-76
AB  - BACKGROUND: Single nucleotide polymorphisms (SNPs) within the transcription 
      factor 7-like 2 (TCF7L2) gene are well known risk variants for type 2 diabetes 
      mellitus (T2DM). The association between TCF7L2 SNPs and T2DM has been 
      investigated in several studies, but the results are controversial. In this 
      study, we investigated whether the rs7903146, rs12255372, and rs290487 
      polymorphisms of TCF7L2 are associated with T2DM per se or metabolic traits 
      related to this disease in a Kurdish ethnic group of Iran. METHODS: In all, 173 
      patients with T2DM and 173 normoglycemic subjects were included in this study. 
      All subjects were genotyped using polymerase chain reaction-restriction fragment 
      length polymorphism (PCR-RFLP). Genotypic and allelic frequencies were then 
      analyzed in each group. Serum lipids, fasting glucose, fasting serum insulin, 
      HOMA-IR, and HbA1c levels were determined by conventional methods. RESULTS: 
      T-allele and genotype frequencies of rs7903146, rs12255372, and rs290487 were 
      significantly different between T2DM and control subjects. The CT genotype (OR = 
      1.98, p = 0.008), TT genotype (OR = 3.54, p = 0.024), and the dominant model (OR 
      = 2.16, p = 0.002) of rs7903146 were associated with T2DM. The GT genotype (OR = 
      2.23, p = 0.005), TT genotype (OR = 4.25, p = 0.046), and the dominant model (OR 
      = 2.2, p = 0.001) of rs12255372 gave a higher risk for T2DM. The carriers of CT 
      genotype of rs290487 showed a significantly increased risk for T2DM (OR = 2.24, p 
      = 0.003). Similarly, the dominant model of this SNP was found to be significantly 
      associated with T2DM (OR = 2.25, p = 0.002). The control subjects carrying the 
      T-allele of rs7903146 had higher levels of total cholesterol (CC; 4.52 +/- 1.03 
      vs. CT + TT; 5.00 +/- 1.2 mmol/L, p = 0.009) than those with CC genotype. 
      Normoglycemic subjects carrying GT + TT genotypes of rs12255372 had a 
      significantly higher WHR (GG; 0.90 +/- 0.059 vs. GT + TT; 0.93 +/- 0.07, p = 
      0.038) as compared with those with the GG genotype. CONCLUSIONS: The T-allele of 
      rs12255372, rs7903146, and rs290487 polymorphisms of TCF7L2 confer susceptibility 
      to T2DM in the Kurdish population of Iran.
FAU - Shokouhi, Shabnam
AU  - Shokouhi S
FAU - Delpisheh, Ali
AU  - Delpisheh A
FAU - Haghani, Karimeh
AU  - Haghani K
FAU - Mahdizadeh, Mohsen
AU  - Mahdizadeh M
FAU - Bakhtiyari, Salar
AU  - Bakhtiyari S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Clin Lab
JT  - Clinical laboratory
JID - 9705611
RN  - 0 (Blood Glucose)
RN  - 0 (TCF7L2 protein, human)
RN  - 0 (Transcription Factor 7-Like 2 Protein)
SB  - IM
MH  - Aged
MH  - Alleles
MH  - Anthropometry
MH  - Blood Glucose/analysis
MH  - Diabetes Mellitus, Type 2/*ethnology/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Iran
MH  - Male
MH  - Middle Aged
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Restriction Fragment Length
MH  - *Polymorphism, Single Nucleotide
MH  - Transcription Factor 7-Like 2 Protein/*genetics
EDAT- 2014/09/05 06:00
MHDA- 2014/10/07 06:00
CRDT- 2014/09/05 06:00
PHST- 2014/09/05 06:00 [entrez]
PHST- 2014/09/05 06:00 [pubmed]
PHST- 2014/10/07 06:00 [medline]
AID - 10.7754/clin.lab.2013.130809 [doi]
PST - ppublish
SO  - Clin Lab. 2014;60(8):1269-76. doi: 10.7754/clin.lab.2013.130809.