PMID- 25185865
OWN - NLM
STAT- MEDLINE
DCOM- 20151008
LR  - 20141219
IS  - 1740-0929 (Electronic)
IS  - 1344-3941 (Linking)
VI  - 85
IP  - 12
DP  - 2014 Dec
TI  - Differential expression of genes encoding neurotrophic factors and their 
      receptors along the septal-temporal axis of the rat hippocampus.
PG  - 986-93
LID - 10.1111/asj.12268 [doi]
AB  - The hippocampus plays a key role in learning and emotional regulation. The 
      hippocampus' function varies along its septotemporal axis, with the septal pole 
      being more frequently involved in spatial learning and memory, and the temporal 
      pole playing a greater role in emotional behaviors. In this study, we present 
      findings aimed at checking the expression level of the genes encoding 
      neurotrophins and their receptors, including nerve growth factor (NGF), 
      brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and their 
      receptors (TrkA, TrkB and TrkC) in the hippocampus along the septotemporal axis. 
      Using real-time PCR, several different expression patterns were observed. 
      Remarkably, the expression of both NT-3 and TrkA genes in the septal hippocampus 
      was higher than in the middle and temporal hippocampus. Higher expression of NT-3 
      and TrkA may implicate active neurogenesis in the dentate gyrus (DG) of the 
      septal hippocampus because more neurogenesis occurs in the septal than the 
      temporal DG of rats. Finally, the results obtained in this study emphasize the 
      importance of choosing the hippocampal portion along its septotemporal axis for 
      any hippocampal molecular and biochemical experimental studies.
CI  - (c) 2014 Japanese Society of Animal Science.
FAU - Toyoda, Atsushi
AU  - Toyoda A
AD  - United Graduate School of Agricultural Science, Tokyo University of Agriculture 
      and Technology, Fuchu, Japan; College of Agriculture, Ibaraki University, 
      Ibaraki, Japan; Ibaraki University Cooperation between Agriculture and Medical 
      Science (IUCAM), Ibaraki, Japan.
FAU - Iio, Wataru
AU  - Iio W
FAU - Goto, Tatsuhiko
AU  - Goto T
FAU - Koike, Hiroaki
AU  - Koike H
FAU - Tsukahara, Takamitsu
AU  - Tsukahara T
LA  - eng
SI  - GENBANK/M36589
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140903
PL  - Australia
TA  - Anim Sci J
JT  - Animal science journal = Nihon chikusan Gakkaiho
JID - 100956805
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Receptors, Nerve Growth Factor)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - Behavior
MH  - Emotions
MH  - *Gene Expression
MH  - Hippocampus/*metabolism/*physiology
MH  - Learning
MH  - Male
MH  - Memory
MH  - Molecular Sequence Data
MH  - Nerve Growth Factors/*genetics/metabolism
MH  - Neurogenesis
MH  - Rats, Wistar
MH  - Real-Time Polymerase Chain Reaction
MH  - Receptors, Nerve Growth Factor/*genetics/metabolism
OTO - NOTNLM
OT  - RT-PCR
OT  - hippocampus
OT  - neurotrophin
OT  - rat
EDAT- 2014/09/05 06:00
MHDA- 2015/10/09 06:00
CRDT- 2014/09/05 06:00
PHST- 2014/02/18 00:00 [received]
PHST- 2014/06/06 00:00 [accepted]
PHST- 2014/09/05 06:00 [entrez]
PHST- 2014/09/05 06:00 [pubmed]
PHST- 2015/10/09 06:00 [medline]
AID - 10.1111/asj.12268 [doi]
PST - ppublish
SO  - Anim Sci J. 2014 Dec;85(12):986-93. doi: 10.1111/asj.12268. Epub 2014 Sep 3.