PMID- 25186185
OWN - NLM
STAT- MEDLINE
DCOM- 20160901
LR  - 20150316
IS  - 1740-0929 (Electronic)
IS  - 1344-3941 (Linking)
VI  - 86
IP  - 3
DP  - 2015 Mar
TI  - Threonine and tryptophan supplementation enhance porcine respiratory and 
      reproductive syndrome (PRRS) vaccine-induced immune responses of growing pigs.
PG  - 294-304
LID - 10.1111/asj.12272 [doi]
AB  - The aim of the present study was to investigate influences of threonine and 
      tryptophan supplementation (TTS) on immune response of growing pigs inoculated 
      with modified live porcine reproductive and respiratory syndrome virus (PRRSV) 
      vaccine. Twenty growing barrows (Landrace x Yorkshire) were randomly assigned to 
      four groups according to the PRRS vaccination and TTS. Serum samples were 
      collected from all pigs at days 0, 7, 14, 21, 28, 35, 49 post-vaccination (day 0 
      defined as the day of vaccination). Pigs were euthanized and samples collected at 
      day 49 post-vaccination. The results showed that TTS tended to increase weight 
      gain and average daily gain (ADG) of pigs (P < 0.1). PRRS vaccine enhanced serum 
      PRRSV-specific antibody, serum virus neutralizing (SVN) antibody and 
      interferon-gamma, interleukin (IL)-10 and IL-1beta concentrations (P < 0.05). The 
      expression of TLR3 and TLR7 mRNA in lymph nodes were higher in TTS than in the 
      control group after PRRS vaccine inoculation (P < 0.05). TTS diet mitigated lung 
      damage which is induced by PRRS vaccination from microscopic evaluation. These 
      results suggest that dietary TTS could improve growth performance of growing 
      pigs, which may be ascribed to the improved immune response and mitigated lung 
      damage.
CI  - (c) 2014 Japanese Society of Animal Science.
FAU - Xu, Shengyu
AU  - Xu S
AD  - Key Laboratory for Animal Disease Resistance Nutrition of Ministry of Education 
      of China, Institute of Animal Nutrition, Sichuan Agricultural University, Ya'an, 
      China.
FAU - Zhao, Yingfei
AU  - Zhao Y
FAU - Shen, Jie
AU  - Shen J
FAU - Lin, Yan
AU  - Lin Y
FAU - Fang, Zhengfeng
AU  - Fang Z
FAU - Che, Lianqiang
AU  - Che L
FAU - Wu, De
AU  - Wu D
LA  - eng
SI  - GENBANK/AB111939
SI  - GENBANK/AB258453
SI  - GENBANK/U07786
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140903
PL  - Australia
TA  - Anim Sci J
JT  - Animal science journal = Nihon chikusan Gakkaiho
JID - 100956805
RN  - 0 (Antibodies, Neutralizing)
RN  - 0 (Antibodies, Viral)
RN  - 0 (Interleukin-1beta)
RN  - 0 (Toll-Like Receptor 3)
RN  - 0 (Toll-Like Receptor 7)
RN  - 0 (Viral Vaccines)
RN  - 130068-27-8 (Interleukin-10)
RN  - 2ZD004190S (Threonine)
RN  - 82115-62-6 (Interferon-gamma)
RN  - 8DUH1N11BX (Tryptophan)
SB  - IM
MH  - *Animal Feed
MH  - Animals
MH  - Antibodies, Neutralizing/blood
MH  - Antibodies, Viral/blood
MH  - *Dietary Supplements
MH  - Interferon-gamma/blood
MH  - Interleukin-10/blood
MH  - Interleukin-1beta/blood
MH  - Lung Diseases/etiology/therapy
MH  - Lymph Nodes/immunology
MH  - Molecular Sequence Data
MH  - Porcine respiratory and reproductive syndrome virus/*immunology/*isolation & 
      purification
MH  - Swine/*growth & development/*immunology
MH  - Threonine/*administration & dosage/*pharmacology
MH  - Toll-Like Receptor 3/metabolism
MH  - Toll-Like Receptor 7/metabolism
MH  - Tryptophan/*administration & dosage/*pharmacology
MH  - Viral Vaccines/adverse effects/*immunology
MH  - Weight Gain/drug effects
OTO - NOTNLM
OT  - PRRS vaccination
OT  - growing pigs
OT  - immune response
OT  - threonine
OT  - tryptophan
EDAT- 2014/09/05 06:00
MHDA- 2016/09/02 06:00
CRDT- 2014/09/05 06:00
PHST- 2014/04/06 00:00 [received]
PHST- 2014/06/06 00:00 [accepted]
PHST- 2014/09/05 06:00 [entrez]
PHST- 2014/09/05 06:00 [pubmed]
PHST- 2016/09/02 06:00 [medline]
AID - 10.1111/asj.12272 [doi]
PST - ppublish
SO  - Anim Sci J. 2015 Mar;86(3):294-304. doi: 10.1111/asj.12272. Epub 2014 Sep 3.