PMID- 25186590
OWN - NLM
STAT- MEDLINE
DCOM- 20150901
LR  - 20220408
IS  - 1537-6591 (Electronic)
IS  - 1058-4838 (Linking)
VI  - 59
IP  - 12
DP  - 2014 Dec 15
TI  - Hepatitis C virus (HCV) antibody dynamics following acute HCV infection and 
      reinfection among HIV-infected men who have sex with men.
PG  - 1678-85
LID - 10.1093/cid/ciu695 [doi]
AB  - BACKGROUND: A decline of hepatitis C virus (HCV) antibody titers (anti-HCV), 
      ultimately resulting in seroreversion, has been reported following clearance of 
      viremia in both acute and chronic HCV infection. However, frequency of 
      seroreversion remains unknown in human immunodeficiency virus 
      (HIV)/HCV-coinfected patients. We describe anti-HCV dynamics among HIV-infected 
      men who have sex with men (MSM) following acute HCV infection and reinfection. 
      METHODS: Primary acute HCV infection was assumed when a subject was anti-HCV 
      negative prior to the first positive HCV RNA test. Anti-HCV was measured at least 
      annually in 63 HIV-infected MSM, with a median follow-up of 4.0 years 
      (interquartile range [IQR], 2.5-5.7 years). Time from HCV infection to 
      seroconversion, and from seroconversion to seroreversion, was estimated using the 
      Kaplan-Meier method. Longitudinal anti-HCV patterns were studied using a 
      random-effects model to adjust for repeated measures. RESULTS: Median time from 
      HCV infection to seroconversion was 74 days (IQR, 47-125 days). Subjects who 
      cleared HCV RNA (n = 36) showed a significant decrease in anti-HCV levels (P < 
      .001). Among 31 subjects with sustained virologic response (SVR), anti-HCV became 
      undetectable during follow-up in 8; cumulative incidence of seroreversion within 
      3 years after seroconversion was 37% (95% confidence interval, 18%-66%). Eighteen 
      subjects became reinfected during follow-up; this coincided with a subsequent 
      increase in anti-HCV reactivity. CONCLUSIONS: A decline of anti-HCV reactivity 
      was associated with HCV RNA clearance. Seroreversion was very common following 
      SVR. Upon reinfection, anti-HCV levels increased again. Monitoring anti-HCV 
      levels might therefore be an effective alternative for diagnosis of HCV 
      reinfection.
CI  - (c) The Author 2014. Published by Oxford University Press on behalf of the 
      Infectious Diseases Society of America. All rights reserved. For Permissions, 
      please e-mail: journals.permissions@oup.com.
FAU - Vanhommerig, Joost W
AU  - Vanhommerig JW
FAU - Thomas, Xiomara V
AU  - Thomas XV
FAU - van der Meer, Jan T M
AU  - van der Meer JT
FAU - Geskus, Ronald B
AU  - Geskus RB
FAU - Bruisten, Sylvia M
AU  - Bruisten SM
FAU - Molenkamp, Richard
AU  - Molenkamp R
FAU - Prins, Maria
AU  - Prins M
FAU - Schinkel, Janke
AU  - Schinkel J
CN  - MOSAIC (MSM Observational Study for Acute Infection with hepatitis C) Study Group
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140903
PL  - United States
TA  - Clin Infect Dis
JT  - Clinical infectious diseases : an official publication of the Infectious Diseases 
      Society of America
JID - 9203213
RN  - 0 (Hepatitis C Antibodies)
SB  - IM
CIN - Clin Infect Dis. 2014 Dec 15;59(12):1694-5. PMID: 25186589
MH  - Adult
MH  - Coinfection/blood/immunology
MH  - HIV Infections/*blood/*immunology
MH  - Hepatitis C/*blood/*immunology
MH  - Hepatitis C Antibodies/*blood
MH  - *Homosexuality, Male
MH  - Humans
MH  - Male
MH  - Middle Aged
OTO - NOTNLM
OT  - HCV reinfection
OT  - HIV/HCV coinfection
OT  - acute HCV
OT  - men who have sex with men
FIR - Arends, J
IR  - Arends J
FIR - van Baarle, D
IR  - van Baarle D
FIR - van den Berk, G
IR  - van den Berk G
FIR - Brinkman, K
IR  - Brinkman K
FIR - Coutinho, R
IR  - Coutinho R
FIR - van den Ende, M
IR  - van den Ende M
FIR - Grady, B
IR  - Grady B
FIR - Gras, L
IR  - Gras L
FIR - Ho, C
IR  - Ho C
FIR - Kwa, D
IR  - Kwa D
FIR - van de Laar, T
IR  - van de Laar T
FIR - Lambers, F
IR  - Lambers F
FIR - Mulder, J
IR  - Mulder J
FIR - Reesink, H
IR  - Reesink H
FIR - Smit, C
IR  - Smit C
FIR - van der Valk, M
IR  - van der Valk M
FIR - van der Veldt, W
IR  - van der Veldt W
FIR - Karlas, J
IR  - Karlas J
FIR - Bakker, M
IR  - Bakker M
FIR - Visser, G
IR  - Visser G
FIR - Buswell, C
IR  - Buswell C
EDAT- 2014/09/05 06:00
MHDA- 2015/09/02 06:00
CRDT- 2014/09/05 06:00
PHST- 2014/09/05 06:00 [entrez]
PHST- 2014/09/05 06:00 [pubmed]
PHST- 2015/09/02 06:00 [medline]
AID - ciu695 [pii]
AID - 10.1093/cid/ciu695 [doi]
PST - ppublish
SO  - Clin Infect Dis. 2014 Dec 15;59(12):1678-85. doi: 10.1093/cid/ciu695. Epub 2014 
      Sep 3.