PMID- 25186863 OWN - NLM STAT- MEDLINE DCOM- 20141217 LR - 20180816 IS - 1526-632X (Electronic) IS - 0028-3878 (Linking) VI - 83 IP - 15 DP - 2014 Oct 7 TI - Influence of BDNF Val66Met on the relationship between physical activity and brain volume. PG - 1345-52 LID - 10.1212/WNL.0000000000000867 [doi] AB - OBJECTIVE: To investigate the association between habitual physical activity levels and brain temporal lobe volumes, and the interaction with the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism. METHODS: This study is a cross-sectional analysis of 114 cognitively healthy men and women aged 60 years and older. Brain volumes quantified by MRI were correlated with self-reported physical activity levels. The effect of the interaction between physical activity and the BDNF Val66Met polymorphism on brain structure volumes was assessed. Post hoc analyses were completed to evaluate the influence of the APOE epsilon4 allele on any found associations. RESULTS: The BDNF Val66Met polymorphism interacted with physical activity to be associated with hippocampal (beta = -0.22, p = 0.02) and temporal lobe (beta = -0.28, p = 0.003) volumes. In Val/Val homozygotes, higher levels of physical activity were associated with larger hippocampal and temporal lobe volumes, whereas in Met carriers, higher levels of physical activity were associated with smaller temporal lobe volume. CONCLUSION: The findings from this study support higher physical activity levels in the potential attenuation of age- and disease-related hippocampal and temporal lobe volume loss in Val/Val homozygotes. CI - (c) 2014 American Academy of Neurology. FAU - Brown, Belinda M AU - Brown BM AD - From the Centre of Excellence for Alzheimer's Disease Research & Care (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), School of Medical Sciences, Edith Cowan University, Joondalup; School of Psychiatry and Clinical Neurosciences (B.M.B., K.T., R.N.M.), University of Western Australia, Perth; McCusker Alzheimer's Research Foundation (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), Perth; CSIRO Preventative Health National Research Flagship (P.B.), The Australian e-Health Research Centre-BioMedIA, Herston; School of Psychology and Exercise Science (J.J.P.), Murdoch University, Perth; CSIRO (S.B.), Mathematics, Informatics and Statistics, Floreat, Australia; Departament de Psiquiatria i Psicobiologia Clinica (D.B.-F.), Facultat de Medicina, Universitat de Barcelona, and Institut d'Investigacions Biomediques August Pi i Sunyer, Catalonia, Spain; The Florey Institute of Neuroscience and Mental Health (V.L.V., A.R., A.B., K.A.E., C.L.M., P.M.), The University of Melbourne, Parkville; National Ageing Research Institute (K.A.E., D.A.), Parkville; CSIRO (S.L.M.), Preventative Health Flagship, CMSE, Parkville; Department of Nuclear Medicine & Centre for PET (V.L.V., C.C.R.), Austin Health, Heidelberg; Academic Unit for Psychiatry of Old Age (K.A.E., D.A.), Department of Psychiatry, The University of Melbourne, St. Vincent's Aged Psychiatry Service, St. George's Hospital, Victoria; and CogState Ltd. (P.M.), Melbourne, Australia. FAU - Bourgeat, Pierrick AU - Bourgeat P AD - From the Centre of Excellence for Alzheimer's Disease Research & Care (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), School of Medical Sciences, Edith Cowan University, Joondalup; School of Psychiatry and Clinical Neurosciences (B.M.B., K.T., R.N.M.), University of Western Australia, Perth; McCusker Alzheimer's Research Foundation (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), Perth; CSIRO Preventative Health National Research Flagship (P.B.), The Australian e-Health Research Centre-BioMedIA, Herston; School of Psychology and Exercise Science (J.J.P.), Murdoch University, Perth; CSIRO (S.B.), Mathematics, Informatics and Statistics, Floreat, Australia; Departament de Psiquiatria i Psicobiologia Clinica (D.B.-F.), Facultat de Medicina, Universitat de Barcelona, and Institut d'Investigacions Biomediques August Pi i Sunyer, Catalonia, Spain; The Florey Institute of Neuroscience and Mental Health (V.L.V., A.R., A.B., K.A.E., C.L.M., P.M.), The University of Melbourne, Parkville; National Ageing Research Institute (K.A.E., D.A.), Parkville; CSIRO (S.L.M.), Preventative Health Flagship, CMSE, Parkville; Department of Nuclear Medicine & Centre for PET (V.L.V., C.C.R.), Austin Health, Heidelberg; Academic Unit for Psychiatry of Old Age (K.A.E., D.A.), Department of Psychiatry, The University of Melbourne, St. Vincent's Aged Psychiatry Service, St. George's Hospital, Victoria; and CogState Ltd. (P.M.), Melbourne, Australia. FAU - Peiffer, Jeremiah J AU - Peiffer JJ AD - From the Centre of Excellence for Alzheimer's Disease Research & Care (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), School of Medical Sciences, Edith Cowan University, Joondalup; School of Psychiatry and Clinical Neurosciences (B.M.B., K.T., R.N.M.), University of Western Australia, Perth; McCusker Alzheimer's Research Foundation (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), Perth; CSIRO Preventative Health National Research Flagship (P.B.), The Australian e-Health Research Centre-BioMedIA, Herston; School of Psychology and Exercise Science (J.J.P.), Murdoch University, Perth; CSIRO (S.B.), Mathematics, Informatics and Statistics, Floreat, Australia; Departament de Psiquiatria i Psicobiologia Clinica (D.B.-F.), Facultat de Medicina, Universitat de Barcelona, and Institut d'Investigacions Biomediques August Pi i Sunyer, Catalonia, Spain; The Florey Institute of Neuroscience and Mental Health (V.L.V., A.R., A.B., K.A.E., C.L.M., P.M.), The University of Melbourne, Parkville; National Ageing Research Institute (K.A.E., D.A.), Parkville; CSIRO (S.L.M.), Preventative Health Flagship, CMSE, Parkville; Department of Nuclear Medicine & Centre for PET (V.L.V., C.C.R.), Austin Health, Heidelberg; Academic Unit for Psychiatry of Old Age (K.A.E., D.A.), Department of Psychiatry, The University of Melbourne, St. Vincent's Aged Psychiatry Service, St. George's Hospital, Victoria; and CogState Ltd. (P.M.), Melbourne, Australia. FAU - Burnham, Samantha AU - Burnham S AD - From the Centre of Excellence for Alzheimer's Disease Research & Care (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), School of Medical Sciences, Edith Cowan University, Joondalup; School of Psychiatry and Clinical Neurosciences (B.M.B., K.T., R.N.M.), University of Western Australia, Perth; McCusker Alzheimer's Research Foundation (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), Perth; CSIRO Preventative Health National Research Flagship (P.B.), The Australian e-Health Research Centre-BioMedIA, Herston; School of Psychology and Exercise Science (J.J.P.), Murdoch University, Perth; CSIRO (S.B.), Mathematics, Informatics and Statistics, Floreat, Australia; Departament de Psiquiatria i Psicobiologia Clinica (D.B.-F.), Facultat de Medicina, Universitat de Barcelona, and Institut d'Investigacions Biomediques August Pi i Sunyer, Catalonia, Spain; The Florey Institute of Neuroscience and Mental Health (V.L.V., A.R., A.B., K.A.E., C.L.M., P.M.), The University of Melbourne, Parkville; National Ageing Research Institute (K.A.E., D.A.), Parkville; CSIRO (S.L.M.), Preventative Health Flagship, CMSE, Parkville; Department of Nuclear Medicine & Centre for PET (V.L.V., C.C.R.), Austin Health, Heidelberg; Academic Unit for Psychiatry of Old Age (K.A.E., D.A.), Department of Psychiatry, The University of Melbourne, St. Vincent's Aged Psychiatry Service, St. George's Hospital, Victoria; and CogState Ltd. (P.M.), Melbourne, Australia. FAU - Laws, Simon M AU - Laws SM AD - From the Centre of Excellence for Alzheimer's Disease Research & Care (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), School of Medical Sciences, Edith Cowan University, Joondalup; School of Psychiatry and Clinical Neurosciences (B.M.B., K.T., R.N.M.), University of Western Australia, Perth; McCusker Alzheimer's Research Foundation (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), Perth; CSIRO Preventative Health National Research Flagship (P.B.), The Australian e-Health Research Centre-BioMedIA, Herston; School of Psychology and Exercise Science (J.J.P.), Murdoch University, Perth; CSIRO (S.B.), Mathematics, Informatics and Statistics, Floreat, Australia; Departament de Psiquiatria i Psicobiologia Clinica (D.B.-F.), Facultat de Medicina, Universitat de Barcelona, and Institut d'Investigacions Biomediques August Pi i Sunyer, Catalonia, Spain; The Florey Institute of Neuroscience and Mental Health (V.L.V., A.R., A.B., K.A.E., C.L.M., P.M.), The University of Melbourne, Parkville; National Ageing Research Institute (K.A.E., D.A.), Parkville; CSIRO (S.L.M.), Preventative Health Flagship, CMSE, Parkville; Department of Nuclear Medicine & Centre for PET (V.L.V., C.C.R.), Austin Health, Heidelberg; Academic Unit for Psychiatry of Old Age (K.A.E., D.A.), Department of Psychiatry, The University of Melbourne, St. Vincent's Aged Psychiatry Service, St. George's Hospital, Victoria; and CogState Ltd. (P.M.), Melbourne, Australia. FAU - Rainey-Smith, Stephanie R AU - Rainey-Smith SR AD - From the Centre of Excellence for Alzheimer's Disease Research & Care (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), School of Medical Sciences, Edith Cowan University, Joondalup; School of Psychiatry and Clinical Neurosciences (B.M.B., K.T., R.N.M.), University of Western Australia, Perth; McCusker Alzheimer's Research Foundation (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), Perth; CSIRO Preventative Health National Research Flagship (P.B.), The Australian e-Health Research Centre-BioMedIA, Herston; School of Psychology and Exercise Science (J.J.P.), Murdoch University, Perth; CSIRO (S.B.), Mathematics, Informatics and Statistics, Floreat, Australia; Departament de Psiquiatria i Psicobiologia Clinica (D.B.-F.), Facultat de Medicina, Universitat de Barcelona, and Institut d'Investigacions Biomediques August Pi i Sunyer, Catalonia, Spain; The Florey Institute of Neuroscience and Mental Health (V.L.V., A.R., A.B., K.A.E., C.L.M., P.M.), The University of Melbourne, Parkville; National Ageing Research Institute (K.A.E., D.A.), Parkville; CSIRO (S.L.M.), Preventative Health Flagship, CMSE, Parkville; Department of Nuclear Medicine & Centre for PET (V.L.V., C.C.R.), Austin Health, Heidelberg; Academic Unit for Psychiatry of Old Age (K.A.E., D.A.), Department of Psychiatry, The University of Melbourne, St. Vincent's Aged Psychiatry Service, St. George's Hospital, Victoria; and CogState Ltd. (P.M.), Melbourne, Australia. FAU - Bartres-Faz, David AU - Bartres-Faz D AD - From the Centre of Excellence for Alzheimer's Disease Research & Care (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), School of Medical Sciences, Edith Cowan University, Joondalup; School of Psychiatry and Clinical Neurosciences (B.M.B., K.T., R.N.M.), University of Western Australia, Perth; McCusker Alzheimer's Research Foundation (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), Perth; CSIRO Preventative Health National Research Flagship (P.B.), The Australian e-Health Research Centre-BioMedIA, Herston; School of Psychology and Exercise Science (J.J.P.), Murdoch University, Perth; CSIRO (S.B.), Mathematics, Informatics and Statistics, Floreat, Australia; Departament de Psiquiatria i Psicobiologia Clinica (D.B.-F.), Facultat de Medicina, Universitat de Barcelona, and Institut d'Investigacions Biomediques August Pi i Sunyer, Catalonia, Spain; The Florey Institute of Neuroscience and Mental Health (V.L.V., A.R., A.B., K.A.E., C.L.M., P.M.), The University of Melbourne, Parkville; National Ageing Research Institute (K.A.E., D.A.), Parkville; CSIRO (S.L.M.), Preventative Health Flagship, CMSE, Parkville; Department of Nuclear Medicine & Centre for PET (V.L.V., C.C.R.), Austin Health, Heidelberg; Academic Unit for Psychiatry of Old Age (K.A.E., D.A.), Department of Psychiatry, The University of Melbourne, St. Vincent's Aged Psychiatry Service, St. George's Hospital, Victoria; and CogState Ltd. (P.M.), Melbourne, Australia. FAU - Villemagne, Victor L AU - Villemagne VL AD - From the Centre of Excellence for Alzheimer's Disease Research & Care (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), School of Medical Sciences, Edith Cowan University, Joondalup; School of Psychiatry and Clinical Neurosciences (B.M.B., K.T., R.N.M.), University of Western Australia, Perth; McCusker Alzheimer's Research Foundation (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), Perth; CSIRO Preventative Health National Research Flagship (P.B.), The Australian e-Health Research Centre-BioMedIA, Herston; School of Psychology and Exercise Science (J.J.P.), Murdoch University, Perth; CSIRO (S.B.), Mathematics, Informatics and Statistics, Floreat, Australia; Departament de Psiquiatria i Psicobiologia Clinica (D.B.-F.), Facultat de Medicina, Universitat de Barcelona, and Institut d'Investigacions Biomediques August Pi i Sunyer, Catalonia, Spain; The Florey Institute of Neuroscience and Mental Health (V.L.V., A.R., A.B., K.A.E., C.L.M., P.M.), The University of Melbourne, Parkville; National Ageing Research Institute (K.A.E., D.A.), Parkville; CSIRO (S.L.M.), Preventative Health Flagship, CMSE, Parkville; Department of Nuclear Medicine & Centre for PET (V.L.V., C.C.R.), Austin Health, Heidelberg; Academic Unit for Psychiatry of Old Age (K.A.E., D.A.), Department of Psychiatry, The University of Melbourne, St. Vincent's Aged Psychiatry Service, St. George's Hospital, Victoria; and CogState Ltd. (P.M.), Melbourne, Australia. FAU - Taddei, Kevin AU - Taddei K AD - From the Centre of Excellence for Alzheimer's Disease Research & Care (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), School of Medical Sciences, Edith Cowan University, Joondalup; School of Psychiatry and Clinical Neurosciences (B.M.B., K.T., R.N.M.), University of Western Australia, Perth; McCusker Alzheimer's Research Foundation (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), Perth; CSIRO Preventative Health National Research Flagship (P.B.), The Australian e-Health Research Centre-BioMedIA, Herston; School of Psychology and Exercise Science (J.J.P.), Murdoch University, Perth; CSIRO (S.B.), Mathematics, Informatics and Statistics, Floreat, Australia; Departament de Psiquiatria i Psicobiologia Clinica (D.B.-F.), Facultat de Medicina, Universitat de Barcelona, and Institut d'Investigacions Biomediques August Pi i Sunyer, Catalonia, Spain; The Florey Institute of Neuroscience and Mental Health (V.L.V., A.R., A.B., K.A.E., C.L.M., P.M.), The University of Melbourne, Parkville; National Ageing Research Institute (K.A.E., D.A.), Parkville; CSIRO (S.L.M.), Preventative Health Flagship, CMSE, Parkville; Department of Nuclear Medicine & Centre for PET (V.L.V., C.C.R.), Austin Health, Heidelberg; Academic Unit for Psychiatry of Old Age (K.A.E., D.A.), Department of Psychiatry, The University of Melbourne, St. Vincent's Aged Psychiatry Service, St. George's Hospital, Victoria; and CogState Ltd. (P.M.), Melbourne, Australia. FAU - Rembach, Alan AU - Rembach A AD - From the Centre of Excellence for Alzheimer's Disease Research & Care (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), School of Medical Sciences, Edith Cowan University, Joondalup; School of Psychiatry and Clinical Neurosciences (B.M.B., K.T., R.N.M.), University of Western Australia, Perth; McCusker Alzheimer's Research Foundation (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), Perth; CSIRO Preventative Health National Research Flagship (P.B.), The Australian e-Health Research Centre-BioMedIA, Herston; School of Psychology and Exercise Science (J.J.P.), Murdoch University, Perth; CSIRO (S.B.), Mathematics, Informatics and Statistics, Floreat, Australia; Departament de Psiquiatria i Psicobiologia Clinica (D.B.-F.), Facultat de Medicina, Universitat de Barcelona, and Institut d'Investigacions Biomediques August Pi i Sunyer, Catalonia, Spain; The Florey Institute of Neuroscience and Mental Health (V.L.V., A.R., A.B., K.A.E., C.L.M., P.M.), The University of Melbourne, Parkville; National Ageing Research Institute (K.A.E., D.A.), Parkville; CSIRO (S.L.M.), Preventative Health Flagship, CMSE, Parkville; Department of Nuclear Medicine & Centre for PET (V.L.V., C.C.R.), Austin Health, Heidelberg; Academic Unit for Psychiatry of Old Age (K.A.E., D.A.), Department of Psychiatry, The University of Melbourne, St. Vincent's Aged Psychiatry Service, St. George's Hospital, Victoria; and CogState Ltd. (P.M.), Melbourne, Australia. FAU - Bush, Ashley AU - Bush A AD - From the Centre of Excellence for Alzheimer's Disease Research & Care (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), School of Medical Sciences, Edith Cowan University, Joondalup; School of Psychiatry and Clinical Neurosciences (B.M.B., K.T., R.N.M.), University of Western Australia, Perth; McCusker Alzheimer's Research Foundation (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), Perth; CSIRO Preventative Health National Research Flagship (P.B.), The Australian e-Health Research Centre-BioMedIA, Herston; School of Psychology and Exercise Science (J.J.P.), Murdoch University, Perth; CSIRO (S.B.), Mathematics, Informatics and Statistics, Floreat, Australia; Departament de Psiquiatria i Psicobiologia Clinica (D.B.-F.), Facultat de Medicina, Universitat de Barcelona, and Institut d'Investigacions Biomediques August Pi i Sunyer, Catalonia, Spain; The Florey Institute of Neuroscience and Mental Health (V.L.V., A.R., A.B., K.A.E., C.L.M., P.M.), The University of Melbourne, Parkville; National Ageing Research Institute (K.A.E., D.A.), Parkville; CSIRO (S.L.M.), Preventative Health Flagship, CMSE, Parkville; Department of Nuclear Medicine & Centre for PET (V.L.V., C.C.R.), Austin Health, Heidelberg; Academic Unit for Psychiatry of Old Age (K.A.E., D.A.), Department of Psychiatry, The University of Melbourne, St. Vincent's Aged Psychiatry Service, St. George's Hospital, Victoria; and CogState Ltd. (P.M.), Melbourne, Australia. FAU - Ellis, Kathryn A AU - Ellis KA AD - From the Centre of Excellence for Alzheimer's Disease Research & Care (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), School of Medical Sciences, Edith Cowan University, Joondalup; School of Psychiatry and Clinical Neurosciences (B.M.B., K.T., R.N.M.), University of Western Australia, Perth; McCusker Alzheimer's Research Foundation (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), Perth; CSIRO Preventative Health National Research Flagship (P.B.), The Australian e-Health Research Centre-BioMedIA, Herston; School of Psychology and Exercise Science (J.J.P.), Murdoch University, Perth; CSIRO (S.B.), Mathematics, Informatics and Statistics, Floreat, Australia; Departament de Psiquiatria i Psicobiologia Clinica (D.B.-F.), Facultat de Medicina, Universitat de Barcelona, and Institut d'Investigacions Biomediques August Pi i Sunyer, Catalonia, Spain; The Florey Institute of Neuroscience and Mental Health (V.L.V., A.R., A.B., K.A.E., C.L.M., P.M.), The University of Melbourne, Parkville; National Ageing Research Institute (K.A.E., D.A.), Parkville; CSIRO (S.L.M.), Preventative Health Flagship, CMSE, Parkville; Department of Nuclear Medicine & Centre for PET (V.L.V., C.C.R.), Austin Health, Heidelberg; Academic Unit for Psychiatry of Old Age (K.A.E., D.A.), Department of Psychiatry, The University of Melbourne, St. Vincent's Aged Psychiatry Service, St. George's Hospital, Victoria; and CogState Ltd. (P.M.), Melbourne, Australia. FAU - Macaulay, S Lance AU - Macaulay SL AD - From the Centre of Excellence for Alzheimer's Disease Research & Care (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), School of Medical Sciences, Edith Cowan University, Joondalup; School of Psychiatry and Clinical Neurosciences (B.M.B., K.T., R.N.M.), University of Western Australia, Perth; McCusker Alzheimer's Research Foundation (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), Perth; CSIRO Preventative Health National Research Flagship (P.B.), The Australian e-Health Research Centre-BioMedIA, Herston; School of Psychology and Exercise Science (J.J.P.), Murdoch University, Perth; CSIRO (S.B.), Mathematics, Informatics and Statistics, Floreat, Australia; Departament de Psiquiatria i Psicobiologia Clinica (D.B.-F.), Facultat de Medicina, Universitat de Barcelona, and Institut d'Investigacions Biomediques August Pi i Sunyer, Catalonia, Spain; The Florey Institute of Neuroscience and Mental Health (V.L.V., A.R., A.B., K.A.E., C.L.M., P.M.), The University of Melbourne, Parkville; National Ageing Research Institute (K.A.E., D.A.), Parkville; CSIRO (S.L.M.), Preventative Health Flagship, CMSE, Parkville; Department of Nuclear Medicine & Centre for PET (V.L.V., C.C.R.), Austin Health, Heidelberg; Academic Unit for Psychiatry of Old Age (K.A.E., D.A.), Department of Psychiatry, The University of Melbourne, St. Vincent's Aged Psychiatry Service, St. George's Hospital, Victoria; and CogState Ltd. (P.M.), Melbourne, Australia. FAU - Rowe, Christopher C AU - Rowe CC AD - From the Centre of Excellence for Alzheimer's Disease Research & Care (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), School of Medical Sciences, Edith Cowan University, Joondalup; School of Psychiatry and Clinical Neurosciences (B.M.B., K.T., R.N.M.), University of Western Australia, Perth; McCusker Alzheimer's Research Foundation (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), Perth; CSIRO Preventative Health National Research Flagship (P.B.), The Australian e-Health Research Centre-BioMedIA, Herston; School of Psychology and Exercise Science (J.J.P.), Murdoch University, Perth; CSIRO (S.B.), Mathematics, Informatics and Statistics, Floreat, Australia; Departament de Psiquiatria i Psicobiologia Clinica (D.B.-F.), Facultat de Medicina, Universitat de Barcelona, and Institut d'Investigacions Biomediques August Pi i Sunyer, Catalonia, Spain; The Florey Institute of Neuroscience and Mental Health (V.L.V., A.R., A.B., K.A.E., C.L.M., P.M.), The University of Melbourne, Parkville; National Ageing Research Institute (K.A.E., D.A.), Parkville; CSIRO (S.L.M.), Preventative Health Flagship, CMSE, Parkville; Department of Nuclear Medicine & Centre for PET (V.L.V., C.C.R.), Austin Health, Heidelberg; Academic Unit for Psychiatry of Old Age (K.A.E., D.A.), Department of Psychiatry, The University of Melbourne, St. Vincent's Aged Psychiatry Service, St. George's Hospital, Victoria; and CogState Ltd. (P.M.), Melbourne, Australia. FAU - Ames, David AU - Ames D AD - From the Centre of Excellence for Alzheimer's Disease Research & Care (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), School of Medical Sciences, Edith Cowan University, Joondalup; School of Psychiatry and Clinical Neurosciences (B.M.B., K.T., R.N.M.), University of Western Australia, Perth; McCusker Alzheimer's Research Foundation (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), Perth; CSIRO Preventative Health National Research Flagship (P.B.), The Australian e-Health Research Centre-BioMedIA, Herston; School of Psychology and Exercise Science (J.J.P.), Murdoch University, Perth; CSIRO (S.B.), Mathematics, Informatics and Statistics, Floreat, Australia; Departament de Psiquiatria i Psicobiologia Clinica (D.B.-F.), Facultat de Medicina, Universitat de Barcelona, and Institut d'Investigacions Biomediques August Pi i Sunyer, Catalonia, Spain; The Florey Institute of Neuroscience and Mental Health (V.L.V., A.R., A.B., K.A.E., C.L.M., P.M.), The University of Melbourne, Parkville; National Ageing Research Institute (K.A.E., D.A.), Parkville; CSIRO (S.L.M.), Preventative Health Flagship, CMSE, Parkville; Department of Nuclear Medicine & Centre for PET (V.L.V., C.C.R.), Austin Health, Heidelberg; Academic Unit for Psychiatry of Old Age (K.A.E., D.A.), Department of Psychiatry, The University of Melbourne, St. Vincent's Aged Psychiatry Service, St. George's Hospital, Victoria; and CogState Ltd. (P.M.), Melbourne, Australia. FAU - Masters, Colin L AU - Masters CL AD - From the Centre of Excellence for Alzheimer's Disease Research & Care (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), School of Medical Sciences, Edith Cowan University, Joondalup; School of Psychiatry and Clinical Neurosciences (B.M.B., K.T., R.N.M.), University of Western Australia, Perth; McCusker Alzheimer's Research Foundation (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), Perth; CSIRO Preventative Health National Research Flagship (P.B.), The Australian e-Health Research Centre-BioMedIA, Herston; School of Psychology and Exercise Science (J.J.P.), Murdoch University, Perth; CSIRO (S.B.), Mathematics, Informatics and Statistics, Floreat, Australia; Departament de Psiquiatria i Psicobiologia Clinica (D.B.-F.), Facultat de Medicina, Universitat de Barcelona, and Institut d'Investigacions Biomediques August Pi i Sunyer, Catalonia, Spain; The Florey Institute of Neuroscience and Mental Health (V.L.V., A.R., A.B., K.A.E., C.L.M., P.M.), The University of Melbourne, Parkville; National Ageing Research Institute (K.A.E., D.A.), Parkville; CSIRO (S.L.M.), Preventative Health Flagship, CMSE, Parkville; Department of Nuclear Medicine & Centre for PET (V.L.V., C.C.R.), Austin Health, Heidelberg; Academic Unit for Psychiatry of Old Age (K.A.E., D.A.), Department of Psychiatry, The University of Melbourne, St. Vincent's Aged Psychiatry Service, St. George's Hospital, Victoria; and CogState Ltd. (P.M.), Melbourne, Australia. FAU - Maruff, Paul AU - Maruff P AD - From the Centre of Excellence for Alzheimer's Disease Research & Care (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), School of Medical Sciences, Edith Cowan University, Joondalup; School of Psychiatry and Clinical Neurosciences (B.M.B., K.T., R.N.M.), University of Western Australia, Perth; McCusker Alzheimer's Research Foundation (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), Perth; CSIRO Preventative Health National Research Flagship (P.B.), The Australian e-Health Research Centre-BioMedIA, Herston; School of Psychology and Exercise Science (J.J.P.), Murdoch University, Perth; CSIRO (S.B.), Mathematics, Informatics and Statistics, Floreat, Australia; Departament de Psiquiatria i Psicobiologia Clinica (D.B.-F.), Facultat de Medicina, Universitat de Barcelona, and Institut d'Investigacions Biomediques August Pi i Sunyer, Catalonia, Spain; The Florey Institute of Neuroscience and Mental Health (V.L.V., A.R., A.B., K.A.E., C.L.M., P.M.), The University of Melbourne, Parkville; National Ageing Research Institute (K.A.E., D.A.), Parkville; CSIRO (S.L.M.), Preventative Health Flagship, CMSE, Parkville; Department of Nuclear Medicine & Centre for PET (V.L.V., C.C.R.), Austin Health, Heidelberg; Academic Unit for Psychiatry of Old Age (K.A.E., D.A.), Department of Psychiatry, The University of Melbourne, St. Vincent's Aged Psychiatry Service, St. George's Hospital, Victoria; and CogState Ltd. (P.M.), Melbourne, Australia. FAU - Martins, Ralph N AU - Martins RN AD - From the Centre of Excellence for Alzheimer's Disease Research & Care (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), School of Medical Sciences, Edith Cowan University, Joondalup; School of Psychiatry and Clinical Neurosciences (B.M.B., K.T., R.N.M.), University of Western Australia, Perth; McCusker Alzheimer's Research Foundation (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), Perth; CSIRO Preventative Health National Research Flagship (P.B.), The Australian e-Health Research Centre-BioMedIA, Herston; School of Psychology and Exercise Science (J.J.P.), Murdoch University, Perth; CSIRO (S.B.), Mathematics, Informatics and Statistics, Floreat, Australia; Departament de Psiquiatria i Psicobiologia Clinica (D.B.-F.), Facultat de Medicina, Universitat de Barcelona, and Institut d'Investigacions Biomediques August Pi i Sunyer, Catalonia, Spain; The Florey Institute of Neuroscience and Mental Health (V.L.V., A.R., A.B., K.A.E., C.L.M., P.M.), The University of Melbourne, Parkville; National Ageing Research Institute (K.A.E., D.A.), Parkville; CSIRO (S.L.M.), Preventative Health Flagship, CMSE, Parkville; Department of Nuclear Medicine & Centre for PET (V.L.V., C.C.R.), Austin Health, Heidelberg; Academic Unit for Psychiatry of Old Age (K.A.E., D.A.), Department of Psychiatry, The University of Melbourne, St. Vincent's Aged Psychiatry Service, St. George's Hospital, Victoria; and CogState Ltd. (P.M.), Melbourne, Australia. ralph.n.martins@gmail.com. CN - AIBL Research Group LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20140903 PL - United States TA - Neurology JT - Neurology JID - 0401060 RN - 0 (Apolipoprotein E2) RN - 0 (Brain-Derived Neurotrophic Factor) RN - 7171WSG8A2 (BDNF protein, human) SB - IM CIN - Neurology. 2014 Oct 7;83(15):1351. PMID: 25186860 MH - Aged MH - Apolipoprotein E2/genetics MH - Brain-Derived Neurotrophic Factor/*genetics MH - Cross-Sectional Studies MH - Female MH - Hippocampus/*anatomy & histology MH - Humans MH - Magnetic Resonance Imaging MH - Male MH - Middle Aged MH - Motor Activity/*genetics MH - Neuroimaging MH - Polymorphism, Single Nucleotide/genetics MH - Temporal Lobe/*anatomy & histology EDAT- 2014/09/05 06:00 MHDA- 2014/12/18 06:00 CRDT- 2014/09/05 06:00 PHST- 2014/09/05 06:00 [entrez] PHST- 2014/09/05 06:00 [pubmed] PHST- 2014/12/18 06:00 [medline] AID - WNL.0000000000000867 [pii] AID - 10.1212/WNL.0000000000000867 [doi] PST - ppublish SO - Neurology. 2014 Oct 7;83(15):1345-52. doi: 10.1212/WNL.0000000000000867. Epub 2014 Sep 3.