PMID- 25188359
OWN - NLM
STAT- MEDLINE
DCOM- 20150605
LR  - 20140922
IS  - 1464-522X (Electronic)
IS  - 0309-1902 (Linking)
VI  - 38
IP  - 7
DP  - 2014 Oct
TI  - New insights into blindness; mechanical fatigue of optic nerve head in 
      glaucomatous optic neuropathy.
PG  - 367-71
LID - 10.3109/03091902.2014.950435 [doi]
AB  - A common cause of blindness worldwide is glaucoma. It is characterized by visual 
      field loss which is caused by optic nerve damage leading to glaucomatous optic 
      neuropathy (GON). Modelling of GON development may be helpful for designing 
      strategies to decelerate the rate of GON progression and prevent GON development 
      at early stages. Attempts to complete the modelling of GON development continue. 
      In this paper, it was speculated that the modelling could be more completed 
      through a biomechanical point of view. GON may result from the mechanical fatigue 
      effects of radial tensile stress (TS), caused by intra-ocular pressure (IOP), on 
      the optic nerve head (ONH). The mechanical fatigue rate is influenced by 
      patient's age, the maximum and minimum magnitude of IOP, the amplitude of IOP and 
      TS fluctuations, the ONH geometry, scleral thickness and biomechanical properties 
      of the sclera, particularly the peripapillary part, and the axial length of the 
      globe. Based on this model, more efficient strategies can be developed to augment 
      the ONH and decelerate the progression of glaucomatous optic nerve damage, and 
      even screen high-risk individuals at early stages.
FAU - Norouzpour, Amir
AU  - Norouzpour A
AD  - Eye Research Center, Khatam-Al-Anbia Eye Hospital, Mashhad University of Medical 
      Sciences (MUMS) , Mashhad , Iran and.
FAU - Mehdizadeh, Alireza
AU  - Mehdizadeh A
LA  - eng
PT  - Journal Article
DEP - 20140904
PL  - England
TA  - J Med Eng Technol
JT  - Journal of medical engineering & technology
JID - 7702125
SB  - IM
MH  - Blindness/physiopathology
MH  - Glaucoma/*physiopathology
MH  - Humans
MH  - *Models, Biological
MH  - Optic Disk/*physiopathology
MH  - Optic Nerve Diseases/*physiopathology
MH  - Stress, Mechanical
OTO - NOTNLM
OT  - Glaucoma
OT  - mechanical fatigue
OT  - optic neuropathy
OT  - tensile stress
EDAT- 2014/09/05 06:00
MHDA- 2015/06/06 06:00
CRDT- 2014/09/05 06:00
PHST- 2014/09/05 06:00 [entrez]
PHST- 2014/09/05 06:00 [pubmed]
PHST- 2015/06/06 06:00 [medline]
AID - 10.3109/03091902.2014.950435 [doi]
PST - ppublish
SO  - J Med Eng Technol. 2014 Oct;38(7):367-71. doi: 10.3109/03091902.2014.950435. Epub 
      2014 Sep 4.