PMID- 25188761
OWN - NLM
STAT- MEDLINE
DCOM- 20160906
LR  - 20191210
IS  - 1308-0032 (Electronic)
IS  - 1302-8723 (Linking)
VI  - 14
IP  - 8
DP  - 2014 Dec
TI  - The left atrial phasic functions and the relationship with plasma N-terminal 
      pro-B-type natriuretic peptide levels and symptomatic states in patients with 
      hypertrophic cardiomyopathy.
PG  - 719-27
LID - 10.5152/akd.2014.5101 [doi]
AB  - OBJECTIVE: We aimed to evaluate left atrium (LA) phasic functions and relation 
      with N-terminal pro-B- type natriuretic peptide (NT-proBNP) levels and 
      symptomatic states of the patients with hypertrophic cardiomyopathy (HCM). 
      METHODS: Left atrial volume was calculated at end-systole (Vmax), end-diastole 
      and pre-atrial contraction by echocardiography in 75 patients with HCM and 75 
      control subjects. Left atrial ejection fraction (LAEF), expansion index (LAEI), 
      active emptying volume index (LAAEVI) and fraction (LAAEFr), passive emptying 
      volume index (LAPEVI) and fraction (LAPEFr) were calculated. NT-proBNP levels 
      were measured. RESULTS: Left atrial active emptying volume (LAAEV) positively 
      correlated with Vmax (r=0.343, p=0.003) up to a point, but then reached a plateau 
      with larger LA volumes in HCM group. The LAAEFr was the only variable which was 
      similiar between asymptomatic patients and controls, but was significantly 
      decreased in symptomatic patients (p<0.05). NT-proBNP was correlated with LAEF 
      (r=-0.32, p=0.005), LAEI (r=-0387, p=0.001), and LAAEFr (r=-0.25, p=0.035) but 
      not related with LAPEFr (p=0.4). In receiver operating characteristic curve 
      analysis an NT-proBNP cut-off value of 1415 pg/mL identified reduced LAEF with 
      87% specificity and 59% sensitivity [AUC=0.77 (95% CI: 0.65-0.89), p=0.004], a 
      cut-off value of 820 pg/mL predicted impaired LAEI with 81% specificity ve 67% 
      sensitivity [AUC=0.78 (95% CI: 0.66-0.9), p<0.001]; while a cut-off value of 1320 
      pg/mL predicted impaired LAAEFr with 76% specificity and 67% sensitivity 
      [AUC=0.79 (95% CI: 0.68-0.91), p=0.02]. CONCLUSION: In HCM, LA phasic functions 
      alter according to the Frank-Starling mechanism indicating occurrence of a 
      secondary atrial myopathy. Impairment of LA booster pump function seems to be 
      associated with appearance of symptoms and NT-proBNP levels predict the 
      deterioration of LA reservoir and pump functions in HCM population.
FAU - Tuluce, Kamil
AU  - Tuluce K
AD  - Department of Cardiology, Faculty of Medicine, Ege University; Izmir-Turkey. 
      kamiltuluce@gmail.com.
FAU - Yakar Tuluce, Selcen
AU  - Yakar Tuluce S
FAU - Yavuzgil, Oguz
AU  - Yavuzgil O
FAU - Isayev, Elnur
AU  - Isayev E
FAU - Bilgin, Murat
AU  - Bilgin M
FAU - Akyildiz Akcay, Filiz
AU  - Akyildiz Akcay F
FAU - Nalbantgil, Sanem
AU  - Nalbantgil S
FAU - Ozerkan, Filiz
AU  - Ozerkan F
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140210
PL  - Turkey
TA  - Anadolu Kardiyol Derg
JT  - Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology
JID - 101095069
RN  - 0 (Biomarkers)
RN  - 0 (Peptide Fragments)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Area Under Curve
MH  - Atrial Function, Left
MH  - Biomarkers/*blood
MH  - Cardiomyopathy, Hypertrophic/blood/diagnostic imaging/*physiopathology
MH  - Case-Control Studies
MH  - Echocardiography
MH  - Humans
MH  - Natriuretic Peptide, Brain/*blood
MH  - Peptide Fragments/*blood
MH  - ROC Curve
MH  - Sensitivity and Specificity
EDAT- 2014/09/05 06:00
MHDA- 2016/09/07 06:00
CRDT- 2014/09/05 06:00
PHST- 2014/09/05 06:00 [entrez]
PHST- 2014/09/05 06:00 [pubmed]
PHST- 2016/09/07 06:00 [medline]
AID - 10.5152/akd.2014.5101 [doi]
PST - ppublish
SO  - Anadolu Kardiyol Derg. 2014 Dec;14(8):719-27. doi: 10.5152/akd.2014.5101. Epub 
      2014 Feb 10.