PMID- 25189952
OWN - NLM
STAT- MEDLINE
DCOM- 20150409
LR  - 20140905
IS  - 2542-5641 (Electronic)
IS  - 0366-6999 (Linking)
VI  - 127
IP  - 17
DP  - 2014
TI  - Application of immunosuppressant facilitates the therapy of optic neuritis 
      combined with Sjogren's syndrome.
PG  - 3098-104
AB  - BACKGROUND: Optic neuritis (ON) is often the first symptom of multiple sclerosis 
      (MS) and neuromyelitis optica (NMO) while there has been very little research 
      reported on ON combined with Sjogren's syndrome (SS). The aim of this study is to 
      provide different treatments and services for and NMO patients combined with SS. 
      METHODS: Twenty-seven patients with ON combined SS were divided into two groups: 
      corticosteroid group (C group, methylprednisolone sodium succinate, 14 patients) 
      and corticosteroid+ immunosuppressant group (C+I group, leflunomide, 13 
      patients). ON relapse times in 1 year after treatment, number of patients who 
      relapsed to NMO/MS in 1 years, visual acuity and retina nerve fiber layer (RNFL) 
      thickness were measured. Mann Whitney-Wilcoxon test was used to compare 
      continuous variables and Chi-square test or Fisher's exact test was to compare 
      proportions. RESULTS: ON combined with SS patients had higher incidence rates in 
      middle-aged women who have binocular damage and heavier visual function damage or 
      when there is an easy relapse, and the patients are often hormone dependent. The 
      patients are more likely anti-aquaporin-4 IgG seropositive (70.4%). They are 
      liable to form a centrocecal scotoma and tubular vision. The times of relapse 
      decreased in patients who used immunosuppressant, and a significant difference 
      was found between immunosuppressant and non-immunosuppressant groups in visual 
      acuity recovery during 6-month follow-up period (P < 0.05); however, the RNFL 
      thickness at the four quadrants was not significantly different. CONCLUSIONS: The 
      effect of immunosuppressant plus corticosteroid on the early onset of ON combined 
      with SS was to provide ON remedy and to prevent recurrence in clinics. This study 
      provides a significant reference for the prevention and treatment of ON on the 
      basis of immunosuppressant and corticosteroid.
FAU - Li, Hongyang
AU  - Li H
AD  - Department of Ophthalmology, Chinese People's Liberation Army General Hospital, 
      Beijing 100853, China.
FAU - Liu, Zihao
AU  - Liu Z
AD  - Department of Ophthalmology, Chinese People's Liberation Army General Hospital, 
      Beijing 100853, China.
FAU - Gong, Yan
AU  - Gong Y
AD  - Department of Ophthalmology, Chinese People's Liberation Army General Hospital, 
      Beijing 100853, China.
FAU - Jiang, Zhaocai
AU  - Jiang Z
AD  - Department of Ophthalmology, Chinese People's Liberation Army General Hospital, 
      Beijing 100853, China.
FAU - Zhang, Yixin
AU  - Zhang Y
AD  - Department of Ophthalmology, Chinese People's Liberation Army General Hospital, 
      Beijing 100853, China.
FAU - Dai, Yanli
AU  - Dai Y
AD  - Department of Ophthalmology, Chinese People's Liberation Army General Hospital, 
      Beijing 100853, China.
FAU - Zhang, Yan
AU  - Zhang Y
AD  - Department of Ophthalmology, Chinese People's Liberation Army General Hospital, 
      Beijing 100853, China.
FAU - Wei, Shihui
AU  - Wei S
AD  - Department of Ophthalmology, Chinese People's Liberation Army General Hospital, 
      Beijing 100853, China. Email: faraway_sweet@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Chin Med J (Engl)
JT  - Chinese medical journal
JID - 7513795
RN  - 0 (Adrenal Cortex Hormones)
RN  - 0 (Immunosuppressive Agents)
RN  - 5GMR90S4KN (Methylprednisolone Hemisuccinate)
SB  - IM
MH  - Adolescent
MH  - Adrenal Cortex Hormones/therapeutic use
MH  - Adult
MH  - Aged
MH  - Female
MH  - Humans
MH  - Immunosuppressive Agents/*therapeutic use
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Methylprednisolone Hemisuccinate/therapeutic use
MH  - Middle Aged
MH  - Optic Neuritis/*drug therapy
MH  - Sjogren's Syndrome/*drug therapy
MH  - Visual Acuity/drug effects
MH  - Young Adult
EDAT- 2014/09/06 06:00
MHDA- 2015/04/10 06:00
CRDT- 2014/09/06 06:00
PHST- 2014/09/06 06:00 [entrez]
PHST- 2014/09/06 06:00 [pubmed]
PHST- 2015/04/10 06:00 [medline]
PST - ppublish
SO  - Chin Med J (Engl). 2014;127(17):3098-104.