PMID- 25189990
OWN - NLM
STAT- MEDLINE
DCOM- 20150424
LR  - 20181202
IS  - 1573-2517 (Electronic)
IS  - 0165-0327 (Linking)
VI  - 169
DP  - 2014 Dec
TI  - Thyroid stimulating hormone and serum, plasma, and platelet brain-derived 
      neurotrophic factor during a 3-month follow-up in patients with major depressive 
      disorder.
PG  - 112-7
LID - S0165-0327(14)00485-6 [pii]
LID - 10.1016/j.jad.2014.08.009 [doi]
AB  - BACKGROUND: Thyroid dysfunction and elevated thyroid stimulating hormone (TSH) 
      are common in patients with depression. TSH might exert its function in the brain 
      through blood levels of brain-derived neurotrophic factor (BDNF). BDNF decreases 
      during depressed states and normalize after treatment. The gap is that the 
      association between TSH and BDNF in patients with major depressive disorder (MDD) 
      is unknown. METHODS: We studied 105 subjects >/=18 years of age with MDD and 
      measured serum, plasma, and platelet BDNF at baseline, 1 month and 3 months 
      during antidepressant treatment. Other baseline measurements included 
      hypothalamic-pituitary-thyroid axis hormones such as TSH, triiodothyronine (T3) 
      and thyroxine (T4); hypothalamic-pituitary-adrenal (HPA) axis hormones and 
      hypothalamic-pituitary-gonadal (HPG) axis hormones and prolactin. RESULTS: Linear 
      mixed model effect analyses revealed that baseline TSH level was negatively 
      associated with changes of serum BDNF from baseline to 3 months (F=7.58, p=0.007) 
      after adjusting for age, sex, and body mass index, but was not associated with 
      plasma and platelet BDNF. In contrast, T3 and T4, HPA axis hormones, HPG axis 
      hormones, and prolactin were not associated with serum, plasma, or platelet BDNF 
      levels. Patients in the highest quartile of TSH showed significantly lower serum 
      BDNF than in the other quartiles (F=4.54, p=0.038), but no significant 
      differences were found based on T3 and T4 levels. LIMITATIONS: TSH was only 
      measured at baseline. CONCLUSIONS: Higher TSH is associated with lower baseline 
      and reduced the increase of serum BDNF levels during antidepressant treatment in 
      patients with MDD.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Baek, Ji Hyun
AU  - Baek JH
AD  - Department of Psychiatry, Depression Center, Samsung Medical Center, Sungkyunkwan 
      University School of Medicine, Seoul, Republic of Korea; Bipolar Clinic and 
      Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, 
      USA.
FAU - Kang, Eun-Suk
AU  - Kang ES
AD  - Department of Laboratory Medicine, Samsung Medical Center, Sungkyunkwan 
      University School of Medicine, Seoul, Republic of Korea.
FAU - Fava, Maurizio
AU  - Fava M
AD  - Depression Clinical and Research Program, Massachusetts General Hospital, Harvard 
      Medical School, Boston, USA.
FAU - Mischoulon, David
AU  - Mischoulon D
AD  - Depression Clinical and Research Program, Massachusetts General Hospital, Harvard 
      Medical School, Boston, USA.
FAU - Nierenberg, Andrew A
AU  - Nierenberg AA
AD  - Depression Clinical and Research Program, Massachusetts General Hospital, Harvard 
      Medical School, Boston, USA; Bipolar Clinic and Research Program, Massachusetts 
      General Hospital, Harvard Medical School, Boston, USA.
FAU - Lee, Dongsoo
AU  - Lee D
AD  - Department of Psychiatry, Depression Center, Samsung Medical Center, Sungkyunkwan 
      University School of Medicine, Seoul, Republic of Korea.
FAU - Heo, Jung-Yoon
AU  - Heo JY
AD  - Department of Psychiatry, Depression Center, Samsung Medical Center, Sungkyunkwan 
      University School of Medicine, Seoul, Republic of Korea.
FAU - Jeon, Hong Jin
AU  - Jeon HJ
AD  - Department of Psychiatry, Depression Center, Samsung Medical Center, Sungkyunkwan 
      University School of Medicine, Seoul, Republic of Korea; Samsung Advanced 
      Institute for Health Sciences & Technology (SAIHST), Seoul, Republic of Korea; 
      Bipolar Clinic and Research Program, Massachusetts General Hospital, Harvard 
      Medical School, Boston, USA. Electronic address: jeonhj@skku.edu.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140817
PL  - Netherlands
TA  - J Affect Disord
JT  - Journal of affective disorders
JID - 7906073
RN  - 0 (Antidepressive Agents)
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 06LU7C9H1V (Triiodothyronine)
RN  - 9002-71-5 (Thyrotropin)
RN  - Q51BO43MG4 (Thyroxine)
SB  - IM
MH  - Adult
MH  - Antidepressive Agents/therapeutic use
MH  - Biomarkers/blood
MH  - Blood Platelets/metabolism
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Depressive Disorder, Major/*blood/drug therapy
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Hypothalamo-Hypophyseal System/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Pituitary-Adrenal System/physiopathology
MH  - Thyrotropin/*blood
MH  - Thyroxine/blood
MH  - Treatment Outcome
MH  - Triiodothyronine/blood
OTO - NOTNLM
OT  - BDNF
OT  - Major depressive disorder
OT  - Thyroid hormone
OT  - Thyroid-stimulating hormone
EDAT- 2014/09/06 06:00
MHDA- 2015/04/25 06:00
CRDT- 2014/09/06 06:00
PHST- 2014/03/11 00:00 [received]
PHST- 2014/07/24 00:00 [revised]
PHST- 2014/08/07 00:00 [accepted]
PHST- 2014/09/06 06:00 [entrez]
PHST- 2014/09/06 06:00 [pubmed]
PHST- 2015/04/25 06:00 [medline]
AID - S0165-0327(14)00485-6 [pii]
AID - 10.1016/j.jad.2014.08.009 [doi]
PST - ppublish
SO  - J Affect Disord. 2014 Dec;169:112-7. doi: 10.1016/j.jad.2014.08.009. Epub 2014 
      Aug 17.