PMID- 25190505
OWN - NLM
STAT- MEDLINE
DCOM- 20151123
LR  - 20211021
IS  - 1741-7899 (Electronic)
IS  - 1470-1626 (Print)
IS  - 1470-1626 (Linking)
VI  - 148
IP  - 6
DP  - 2014 Dec
TI  - In utero exposure to persistent organochlorine pollutants and reproductive health 
      in the human male.
PG  - 635-46
LID - 10.1530/REP-13-0488 [doi]
AB  - Persistent organochlorine pollutants (POPs) are ubiquitous, bioaccumulative 
      compounds with potential endocrine-disrupting effects. They cross the placental 
      barrier thereby resulting in in utero exposure of the developing fetus. The 
      objective of this study was to investigate whether maternal serum concentrations 
      of polychlorinated biphenyls (PCBs) and p,p'-dichlorodiphenyldichloroethylene 
      (p,p'-DDE) during pregnancy are associated with son's semen quality and 
      reproductive hormone levels. During 2008-2009, we recruited 176 male offspring 
      from a Danish cohort of pregnant women who participated in a study in 1988-1989. 
      Each provided semen and blood samples that were analyzed for sperm concentration, 
      total sperm count, motility, and morphology, and reproductive hormone levels, 
      respectively. The maternal blood samples were collected in pregnancy week 30 and 
      were analyzed for the concentrations of six PCBs (PCB-118, -138, -153, -156, 
      -170, and -180) and p,p'-DDE. The potential associations between in utero 
      exposure to SigmaPCBs (pmol/ml), Sigmadioxin like-(DL) PCBs (PCB-118 and -156) (pmol/ml), 
      and p,p'-DDE and semen quality and reproductive hormone levels were investigated 
      using multiple regression. Maternal median (range) exposure levels of SigmaPCB, 
      SigmaDL-PCB, and p,p'-DDE were 10.0 (2.1-35.0) pmol/ml, 0.8 (0.2-2.7) pmol/ml, and 
      8.0 (0.7-55.3) pmol/ml, respectively, reflecting typical background exposure 
      levels in the late 1980s in Denmark. Results suggested that in utero exposure to 
      SigmaPCB, SigmaDL-PCB, and p,p'-DDE was not statistically significantly associated with 
      semen quality measures or reproductive hormone levels. Thus, results based on 
      maternal PCB and p,p'-DDE concentrations alone are not indicative of long-term 
      consequences for male reproductive health; however, we cannot exclude that these 
      POPs in concert with other endocrine-modulating compounds may have adverse 
      effects.
CI  - (c) 2014 The authors.
FAU - Vested, Anne
AU  - Vested A
AD  - Department of Occupational MedicineDanish Ramazzini Centre, Aarhus University 
      Hospital, Noerrebrogade 44 Building 2C, DK-8000 Aarhus C, DenmarkSection for 
      EpidemiologyDepartment of Public Health, University of Aarhus, Bartholins Alle 2 
      Building 1260, DK-8000 Aarhus C, DenmarkStatens Serum InstitutCentre for Fetal 
      Programming, Artellerivej 5, DK-2300 Copenhagen S, DenmarkDepartment of 
      Occupational and Environmental MedicineBispebjerg Hospital of Copenhagen 
      University, Bispebjerg Bakke 23 Building 33 1st floor, DK-2400 Copenhagen NV, 
      DenmarkDepartment of Public HealthBiostatistics, Bartholins Alle 2 Building 1261, 
      DK-8000 Aarhus C, DenmarkFaculty of Food Science and NutritionUniversity of 
      Iceland, Eiriksgata 29, 101 Reykjavik, IcelandDepartment of Environmental 
      HealthNational Institute for Health and Welfare (THL), PO Box 95, FI-70701 
      Kuopio, FinlandSection WestInstitute for Biomedicine, Aarhus University, Ole 
      Worms Alle 2, build. 1170, 8000 Aarhus C, Denmark anneveed@rm.dk.
FAU - Ramlau-Hansen, Cecilia H
AU  - Ramlau-Hansen CH
AD  - Department of Occupational MedicineDanish Ramazzini Centre, Aarhus University 
      Hospital, Noerrebrogade 44 Building 2C, DK-8000 Aarhus C, DenmarkSection for 
      EpidemiologyDepartment of Public Health, University of Aarhus, Bartholins Alle 2 
      Building 1260, DK-8000 Aarhus C, DenmarkStatens Serum InstitutCentre for Fetal 
      Programming, Artellerivej 5, DK-2300 Copenhagen S, DenmarkDepartment of 
      Occupational and Environmental MedicineBispebjerg Hospital of Copenhagen 
      University, Bispebjerg Bakke 23 Building 33 1st floor, DK-2400 Copenhagen NV, 
      DenmarkDepartment of Public HealthBiostatistics, Bartholins Alle 2 Building 1261, 
      DK-8000 Aarhus C, DenmarkFaculty of Food Science and NutritionUniversity of 
      Iceland, Eiriksgata 29, 101 Reykjavik, IcelandDepartment of Environmental 
      HealthNational Institute for Health and Welfare (THL), PO Box 95, FI-70701 
      Kuopio, FinlandSection WestInstitute for Biomedicine, Aarhus University, Ole 
      Worms Alle 2, build. 1170, 8000 Aarhus C, Denmark Department of Occupational 
      MedicineDanish Ramazzini Centre, Aarhus University Hospital, Noerrebrogade 44 
      Building 2C, DK-8000 Aarhus C, DenmarkSection for EpidemiologyDepartment of 
      Public Health, University of Aarhus, Bartholins Alle 2 Building 1260, DK-8000 
      Aarhus C, DenmarkStatens Serum InstitutCentre for Fetal Programming, Artellerivej 
      5, DK-2300 Copenhagen S, DenmarkDepartment of Occupational and Environmental 
      MedicineBispebjerg Hospital of Copenhagen University, Bispebjerg Bakke 23 
      Building 33 1st floor, DK-2400 Copenhagen NV, DenmarkDepartment of Public 
      HealthBiostatistics, Bartholins Alle 2 Building 1261, DK-8000 Aarhus C, 
      DenmarkFaculty of Food Science and NutritionUniversity of Iceland, Eiriksgata 29, 
      101 Reykjavik, IcelandDepartment of Environmental HealthNational Institute for 
      Health and Welfare (THL), PO Box 95, FI-70701 Kuopio, FinlandSection 
      WestInstitute for Biomedicine, Aarhus University, Ole Worms Alle 2, build. 1170, 
      8000 Aarhus C, Denmark.
FAU - Olsen, Sjurdur F
AU  - Olsen SF
AD  - Department of Occupational MedicineDanish Ramazzini Centre, Aarhus University 
      Hospital, Noerrebrogade 44 Building 2C, DK-8000 Aarhus C, DenmarkSection for 
      EpidemiologyDepartment of Public Health, University of Aarhus, Bartholins Alle 2 
      Building 1260, DK-8000 Aarhus C, DenmarkStatens Serum InstitutCentre for Fetal 
      Programming, Artellerivej 5, DK-2300 Copenhagen S, DenmarkDepartment of 
      Occupational and Environmental MedicineBispebjerg Hospital of Copenhagen 
      University, Bispebjerg Bakke 23 Building 33 1st floor, DK-2400 Copenhagen NV, 
      DenmarkDepartment of Public HealthBiostatistics, Bartholins Alle 2 Building 1261, 
      DK-8000 Aarhus C, DenmarkFaculty of Food Science and NutritionUniversity of 
      Iceland, Eiriksgata 29, 101 Reykjavik, IcelandDepartment of Environmental 
      HealthNational Institute for Health and Welfare (THL), PO Box 95, FI-70701 
      Kuopio, FinlandSection WestInstitute for Biomedicine, Aarhus University, Ole 
      Worms Alle 2, build. 1170, 8000 Aarhus C, Denmark.
FAU - Bonde, Jens Peter
AU  - Bonde JP
AD  - Department of Occupational MedicineDanish Ramazzini Centre, Aarhus University 
      Hospital, Noerrebrogade 44 Building 2C, DK-8000 Aarhus C, DenmarkSection for 
      EpidemiologyDepartment of Public Health, University of Aarhus, Bartholins Alle 2 
      Building 1260, DK-8000 Aarhus C, DenmarkStatens Serum InstitutCentre for Fetal 
      Programming, Artellerivej 5, DK-2300 Copenhagen S, DenmarkDepartment of 
      Occupational and Environmental MedicineBispebjerg Hospital of Copenhagen 
      University, Bispebjerg Bakke 23 Building 33 1st floor, DK-2400 Copenhagen NV, 
      DenmarkDepartment of Public HealthBiostatistics, Bartholins Alle 2 Building 1261, 
      DK-8000 Aarhus C, DenmarkFaculty of Food Science and NutritionUniversity of 
      Iceland, Eiriksgata 29, 101 Reykjavik, IcelandDepartment of Environmental 
      HealthNational Institute for Health and Welfare (THL), PO Box 95, FI-70701 
      Kuopio, FinlandSection WestInstitute for Biomedicine, Aarhus University, Ole 
      Worms Alle 2, build. 1170, 8000 Aarhus C, Denmark.
FAU - Stovring, Henrik
AU  - Stovring H
AD  - Department of Occupational MedicineDanish Ramazzini Centre, Aarhus University 
      Hospital, Noerrebrogade 44 Building 2C, DK-8000 Aarhus C, DenmarkSection for 
      EpidemiologyDepartment of Public Health, University of Aarhus, Bartholins Alle 2 
      Building 1260, DK-8000 Aarhus C, DenmarkStatens Serum InstitutCentre for Fetal 
      Programming, Artellerivej 5, DK-2300 Copenhagen S, DenmarkDepartment of 
      Occupational and Environmental MedicineBispebjerg Hospital of Copenhagen 
      University, Bispebjerg Bakke 23 Building 33 1st floor, DK-2400 Copenhagen NV, 
      DenmarkDepartment of Public HealthBiostatistics, Bartholins Alle 2 Building 1261, 
      DK-8000 Aarhus C, DenmarkFaculty of Food Science and NutritionUniversity of 
      Iceland, Eiriksgata 29, 101 Reykjavik, IcelandDepartment of Environmental 
      HealthNational Institute for Health and Welfare (THL), PO Box 95, FI-70701 
      Kuopio, FinlandSection WestInstitute for Biomedicine, Aarhus University, Ole 
      Worms Alle 2, build. 1170, 8000 Aarhus C, Denmark.
FAU - Kristensen, Susanne L
AU  - Kristensen SL
AD  - Department of Occupational MedicineDanish Ramazzini Centre, Aarhus University 
      Hospital, Noerrebrogade 44 Building 2C, DK-8000 Aarhus C, DenmarkSection for 
      EpidemiologyDepartment of Public Health, University of Aarhus, Bartholins Alle 2 
      Building 1260, DK-8000 Aarhus C, DenmarkStatens Serum InstitutCentre for Fetal 
      Programming, Artellerivej 5, DK-2300 Copenhagen S, DenmarkDepartment of 
      Occupational and Environmental MedicineBispebjerg Hospital of Copenhagen 
      University, Bispebjerg Bakke 23 Building 33 1st floor, DK-2400 Copenhagen NV, 
      DenmarkDepartment of Public HealthBiostatistics, Bartholins Alle 2 Building 1261, 
      DK-8000 Aarhus C, DenmarkFaculty of Food Science and NutritionUniversity of 
      Iceland, Eiriksgata 29, 101 Reykjavik, IcelandDepartment of Environmental 
      HealthNational Institute for Health and Welfare (THL), PO Box 95, FI-70701 
      Kuopio, FinlandSection WestInstitute for Biomedicine, Aarhus University, Ole 
      Worms Alle 2, build. 1170, 8000 Aarhus C, Denmark.
FAU - Halldorsson, Thorhallur I
AU  - Halldorsson TI
AD  - Department of Occupational MedicineDanish Ramazzini Centre, Aarhus University 
      Hospital, Noerrebrogade 44 Building 2C, DK-8000 Aarhus C, DenmarkSection for 
      EpidemiologyDepartment of Public Health, University of Aarhus, Bartholins Alle 2 
      Building 1260, DK-8000 Aarhus C, DenmarkStatens Serum InstitutCentre for Fetal 
      Programming, Artellerivej 5, DK-2300 Copenhagen S, DenmarkDepartment of 
      Occupational and Environmental MedicineBispebjerg Hospital of Copenhagen 
      University, Bispebjerg Bakke 23 Building 33 1st floor, DK-2400 Copenhagen NV, 
      DenmarkDepartment of Public HealthBiostatistics, Bartholins Alle 2 Building 1261, 
      DK-8000 Aarhus C, DenmarkFaculty of Food Science and NutritionUniversity of 
      Iceland, Eiriksgata 29, 101 Reykjavik, IcelandDepartment of Environmental 
      HealthNational Institute for Health and Welfare (THL), PO Box 95, FI-70701 
      Kuopio, FinlandSection WestInstitute for Biomedicine, Aarhus University, Ole 
      Worms Alle 2, build. 1170, 8000 Aarhus C, Denmark Department of Occupational 
      MedicineDanish Ramazzini Centre, Aarhus University Hospital, Noerrebrogade 44 
      Building 2C, DK-8000 Aarhus C, DenmarkSection for EpidemiologyDepartment of 
      Public Health, University of Aarhus, Bartholins Alle 2 Building 1260, DK-8000 
      Aarhus C, DenmarkStatens Serum InstitutCentre for Fetal Programming, Artellerivej 
      5, DK-2300 Copenhagen S, DenmarkDepartment of Occupational and Environmental 
      MedicineBispebjerg Hospital of Copenhagen University, Bispebjerg Bakke 23 
      Building 33 1st floor, DK-2400 Copenhagen NV, DenmarkDepartment of Public 
      HealthBiostatistics, Bartholins Alle 2 Building 1261, DK-8000 Aarhus C, 
      DenmarkFaculty of Food Science and NutritionUniversity of Iceland, Eiriksgata 29, 
      101 Reykjavik, IcelandDepartment of Environmental HealthNational Institute for 
      Health and Welfare (THL), PO Box 95, FI-70701 Kuopio, FinlandSection 
      WestInstitute for Biomedicine, Aarhus University, Ole Worms Alle 2, build. 1170, 
      8000 Aarhus C, Denmark.
FAU - Rantakokko, Panu
AU  - Rantakokko P
AD  - Department of Occupational MedicineDanish Ramazzini Centre, Aarhus University 
      Hospital, Noerrebrogade 44 Building 2C, DK-8000 Aarhus C, DenmarkSection for 
      EpidemiologyDepartment of Public Health, University of Aarhus, Bartholins Alle 2 
      Building 1260, DK-8000 Aarhus C, DenmarkStatens Serum InstitutCentre for Fetal 
      Programming, Artellerivej 5, DK-2300 Copenhagen S, DenmarkDepartment of 
      Occupational and Environmental MedicineBispebjerg Hospital of Copenhagen 
      University, Bispebjerg Bakke 23 Building 33 1st floor, DK-2400 Copenhagen NV, 
      DenmarkDepartment of Public HealthBiostatistics, Bartholins Alle 2 Building 1261, 
      DK-8000 Aarhus C, DenmarkFaculty of Food Science and NutritionUniversity of 
      Iceland, Eiriksgata 29, 101 Reykjavik, IcelandDepartment of Environmental 
      HealthNational Institute for Health and Welfare (THL), PO Box 95, FI-70701 
      Kuopio, FinlandSection WestInstitute for Biomedicine, Aarhus University, Ole 
      Worms Alle 2, build. 1170, 8000 Aarhus C, Denmark.
FAU - Kiviranta, Hannu
AU  - Kiviranta H
AD  - Department of Occupational MedicineDanish Ramazzini Centre, Aarhus University 
      Hospital, Noerrebrogade 44 Building 2C, DK-8000 Aarhus C, DenmarkSection for 
      EpidemiologyDepartment of Public Health, University of Aarhus, Bartholins Alle 2 
      Building 1260, DK-8000 Aarhus C, DenmarkStatens Serum InstitutCentre for Fetal 
      Programming, Artellerivej 5, DK-2300 Copenhagen S, DenmarkDepartment of 
      Occupational and Environmental MedicineBispebjerg Hospital of Copenhagen 
      University, Bispebjerg Bakke 23 Building 33 1st floor, DK-2400 Copenhagen NV, 
      DenmarkDepartment of Public HealthBiostatistics, Bartholins Alle 2 Building 1261, 
      DK-8000 Aarhus C, DenmarkFaculty of Food Science and NutritionUniversity of 
      Iceland, Eiriksgata 29, 101 Reykjavik, IcelandDepartment of Environmental 
      HealthNational Institute for Health and Welfare (THL), PO Box 95, FI-70701 
      Kuopio, FinlandSection WestInstitute for Biomedicine, Aarhus University, Ole 
      Worms Alle 2, build. 1170, 8000 Aarhus C, Denmark.
FAU - Ernst, Emil H
AU  - Ernst EH
AD  - Department of Occupational MedicineDanish Ramazzini Centre, Aarhus University 
      Hospital, Noerrebrogade 44 Building 2C, DK-8000 Aarhus C, DenmarkSection for 
      EpidemiologyDepartment of Public Health, University of Aarhus, Bartholins Alle 2 
      Building 1260, DK-8000 Aarhus C, DenmarkStatens Serum InstitutCentre for Fetal 
      Programming, Artellerivej 5, DK-2300 Copenhagen S, DenmarkDepartment of 
      Occupational and Environmental MedicineBispebjerg Hospital of Copenhagen 
      University, Bispebjerg Bakke 23 Building 33 1st floor, DK-2400 Copenhagen NV, 
      DenmarkDepartment of Public HealthBiostatistics, Bartholins Alle 2 Building 1261, 
      DK-8000 Aarhus C, DenmarkFaculty of Food Science and NutritionUniversity of 
      Iceland, Eiriksgata 29, 101 Reykjavik, IcelandDepartment of Environmental 
      HealthNational Institute for Health and Welfare (THL), PO Box 95, FI-70701 
      Kuopio, FinlandSection WestInstitute for Biomedicine, Aarhus University, Ole 
      Worms Alle 2, build. 1170, 8000 Aarhus C, Denmark.
FAU - Toft, Gunnar
AU  - Toft G
AD  - Department of Occupational MedicineDanish Ramazzini Centre, Aarhus University 
      Hospital, Noerrebrogade 44 Building 2C, DK-8000 Aarhus C, DenmarkSection for 
      EpidemiologyDepartment of Public Health, University of Aarhus, Bartholins Alle 2 
      Building 1260, DK-8000 Aarhus C, DenmarkStatens Serum InstitutCentre for Fetal 
      Programming, Artellerivej 5, DK-2300 Copenhagen S, DenmarkDepartment of 
      Occupational and Environmental MedicineBispebjerg Hospital of Copenhagen 
      University, Bispebjerg Bakke 23 Building 33 1st floor, DK-2400 Copenhagen NV, 
      DenmarkDepartment of Public HealthBiostatistics, Bartholins Alle 2 Building 1261, 
      DK-8000 Aarhus C, DenmarkFaculty of Food Science and NutritionUniversity of 
      Iceland, Eiriksgata 29, 101 Reykjavik, IcelandDepartment of Environmental 
      HealthNational Institute for Health and Welfare (THL), PO Box 95, FI-70701 
      Kuopio, FinlandSection WestInstitute for Biomedicine, Aarhus University, Ole 
      Worms Alle 2, build. 1170, 8000 Aarhus C, Denmark.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140904
PL  - England
TA  - Reproduction
JT  - Reproduction (Cambridge, England)
JID - 100966036
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 3XMK78S47O (Testosterone)
RN  - 4M7FS82U08 (Dichlorodiphenyl Dichloroethylene)
RN  - 4TI98Z838E (Estradiol)
RN  - 9002-67-9 (Luteinizing Hormone)
RN  - 9002-68-0 (Follicle Stimulating Hormone)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Cohort Studies
MH  - Dichlorodiphenyl Dichloroethylene/adverse effects
MH  - Environmental Pollutants/*adverse effects
MH  - Estradiol/blood
MH  - Female
MH  - Follicle Stimulating Hormone/blood
MH  - Humans
MH  - Hydrocarbons, Chlorinated/*adverse effects
MH  - Longitudinal Studies
MH  - Luteinizing Hormone/blood
MH  - Male
MH  - Polychlorinated Biphenyls/adverse effects
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - *Reproductive Health
MH  - Retrospective Studies
MH  - *Semen Analysis
MH  - Surveys and Questionnaires
MH  - Testosterone/blood
MH  - Young Adult
PMC - PMC4241711
EDAT- 2014/09/06 06:00
MHDA- 2015/12/15 06:00
PMCR- 2014/12/01
CRDT- 2014/09/06 06:00
PHST- 2014/09/06 06:00 [entrez]
PHST- 2014/09/06 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
PHST- 2014/12/01 00:00 [pmc-release]
AID - REP-13-0488 [pii]
AID - REP130488 [pii]
AID - 10.1530/REP-13-0488 [doi]
PST - ppublish
SO  - Reproduction. 2014 Dec;148(6):635-46. doi: 10.1530/REP-13-0488. Epub 2014 Sep 4.