PMID- 25191526
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140905
LR  - 20211021
IS  - 1758-5996 (Print)
IS  - 1758-5996 (Electronic)
IS  - 1758-5996 (Linking)
VI  - 6
IP  - 1
DP  - 2014
TI  - Multivariate epidemiologic analysis of type 2 diabetes mellitus risks in the 
      Lebanese population.
PG  - 89
LID - 10.1186/1758-5996-6-89 [doi]
LID - 89
AB  - BACKGROUND: The burden of diabetes in Lebanon requires well-targeted 
      interventions for screening type 2 diabetes mellitus (T2DM) and prediabetes and 
      prevention of risk factors. Newly recruited 998 Lebanese individuals, in addition 
      to 7,292 already available, were studied to investigate the prevalence of 
      diabetes, prediabetes and their associated risk factors. METHODS: Participants 
      had fasting blood sugar and glycohemoglobin tests in addition to a lipid profile. 
      Clinical and demographic information were obtained from a detailed questionnaire. 
      The relationship between T2DM, its risk factors, and its complications were 
      tested. Comparisons of these risk factors among diabetics, healthy, and coronary 
      artery disease (CAD) patients were performed. RESULTS: The prevalence of T2DM 
      significantly increased with increasing BMI (p < 0.0001). Exercise activity level 
      negatively correlated with the disease (p = 0.002), whereas the prevalence of 
      T2DM (p < 0.0001) and CAD family history (p = 0.006) positively correlated with 
      the affection status. The mean levels of triglycerides and LDL-C were 
      significantly higher in diabetics (1.87; 1.35) compared to individuals with 
      prediabetes (1.63; 1.26) and unaffected controls (1.49; 1.19). People with T2DM 
      showed a significant decrease in HDL-C levels. A strong correlation of overall 
      hyperlipidemia with the diabetes affection status was shown (p < 0.0001). Other 
      comorbid factors such as hypertension (p < 0.0001) and self-reported obesity (p < 
      0.0001) were highly associated with T2DM and prediabetes. Reproductive health of 
      women showed a strong correlation between giving birth to a baby with a high 
      weight and the occurrence of T2DM and prediabetes later in life (p < 0.0001). 
      Retinopathy and peripheral neuropathy were significantly correlated with diabetes 
      and prediabetes (p < 0.0001). CONCLUSIONS: The present study shows an alarming 
      prevalence of diabetes and prediabetes in the studied subgroups representative of 
      the Lebanese population.
FAU - Ghassibe-Sabbagh, Michella
AU  - Ghassibe-Sabbagh M
AD  - School of Medicine, Lebanese American University, Beirut, 1102 2801 Lebanon.
FAU - Deeb, Mary
AU  - Deeb M
AD  - School of Medicine, Lebanese American University, Beirut, 1102 2801 Lebanon.
FAU - Salloum, Angelique K
AU  - Salloum AK
AD  - School of Medicine, Lebanese American University, Beirut, 1102 2801 Lebanon.
FAU - Mouzaya, Francis
AU  - Mouzaya F
AD  - School of Medicine, Lebanese American University, Beirut, 1102 2801 Lebanon.
FAU - Haber, Marc
AU  - Haber M
AD  - School of Medicine, Lebanese American University, Beirut, 1102 2801 Lebanon.
FAU - Al-Sarraj, Yasser
AU  - Al-Sarraj Y
AD  - Shafallah Medical Genetics Center, Doha, Qatar.
FAU - Chami, Youssef
AU  - Chami Y
AD  - School of Medicine, Lebanese American University, Beirut, 1102 2801 Lebanon.
FAU - Akle, Yasmine
AU  - Akle Y
AD  - Centre Hospitalier du Nord-CHN, Zgharta, Lebanon.
FAU - Hirbli, Kamal
AU  - Hirbli K
AD  - School of Medicine, Lebanese American University, Beirut, 1102 2801 Lebanon.
FAU - Nemr, Rita
AU  - Nemr R
AD  - School of Medicine, Lebanese American University, Beirut, 1102 2801 Lebanon.
FAU - Ahdab, Rechdi
AU  - Ahdab R
AD  - School of Medicine, Lebanese American University, Beirut, 1102 2801 Lebanon.
FAU - Platt, Daniel E
AU  - Platt DE
AD  - Bioinformatics and Pattern Discovery, IBM T. J. Watson Research Centre, Yorktown 
      Hgts, NY 10598 USA.
FAU - Abchee, Antoine B
AU  - Abchee AB
AD  - Department of Internal Medicine, American University of Beirut, Beirut, Lebanon.
FAU - El-Shanti, Hatem
AU  - El-Shanti H
AD  - Shafallah Medical Genetics Center, Doha, Qatar.
FAU - Zalloua, Pierre A
AU  - Zalloua PA
AD  - School of Medicine, Lebanese American University, Beirut, 1102 2801 Lebanon ; 
      Harvard School of Public Health, Boston, MA 02215 USA.
LA  - eng
PT  - Journal Article
DEP - 20140821
PL  - England
TA  - Diabetol Metab Syndr
JT  - Diabetology & metabolic syndrome
JID - 101488958
PMC - PMC4153892
OTO - NOTNLM
OT  - Coronary artery disease
OT  - Hyperlipidemia
OT  - Lebanon
OT  - Prediabetes
OT  - Risk factors
OT  - Type 2 diabetes
EDAT- 2014/09/06 06:00
MHDA- 2014/09/06 06:01
PMCR- 2014/08/21
CRDT- 2014/09/06 06:00
PHST- 2014/06/17 00:00 [received]
PHST- 2014/08/08 00:00 [accepted]
PHST- 2014/09/06 06:00 [entrez]
PHST- 2014/09/06 06:00 [pubmed]
PHST- 2014/09/06 06:01 [medline]
PHST- 2014/08/21 00:00 [pmc-release]
AID - 354 [pii]
AID - 10.1186/1758-5996-6-89 [doi]
PST - epublish
SO  - Diabetol Metab Syndr. 2014 Aug 21;6(1):89. doi: 10.1186/1758-5996-6-89. 
      eCollection 2014.