PMID- 25191609
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140905
LR  - 20211021
IS  - 2048-6790 (Print)
IS  - 2048-6790 (Electronic)
IS  - 2048-6790 (Linking)
VI  - 3
DP  - 2014
TI  - Mannoheptulose has differential effects on fasting and postprandial energy 
      expenditure and respiratory quotient in adult Beagle dogs fed diets of different 
      macronutrient contents.
PG  - e17
LID - 10.1017/jns.2014.17 [doi]
LID - e17
AB  - The present study aimed to determine the effects of mannoheptulose (MH) (8 mg/kg) 
      on energy expenditure (EE), respiratory quotient (RQ) and glycaemic response in 
      healthy adult Beagle dogs (n 8; 9.62 (sem 0.31) kg; body condition score 4.5). 
      The study was designed as replicated 4 x 4 Latin squares with a 2 x 2 factorial 
      treatment structure. The dietary treatments were low carbohydrate (CHO) relative 
      to fat diet (LC; 31 % CHO, 28 % fat) with placebo (0 mg/kg) or MH supplement and 
      high CHO relative to fat diet (HC; 54 % CHO, 11 % fat) with placebo (0 mg/kg) or 
      MH supplement. Dogs were fed to maintain body weight (HC and HC(+MH) 3625 (sem 
      295) kJ and LC and LC(+MH) 3542 (sem 284) kJ). Resting and postprandial (0-4 h; 
      5-10 h; 11-17 h; 18-23 h) EE and RQ were determined by indirect calorimetry (days 
      12 or 14). Glycaemic response to a meal (24 h) and plasma MH concentrations were 
      determined on days 12 or 14. Plasma MH followed first-order kinetics, confirming 
      that MH is absorbed and available to the animal. In the presence of high dietary 
      CHO, MH increased postprandial EE (5-10 h only), suggesting MH increased dietary 
      induced thermogenesis. In contrast to earlier reports, MH did not affect serum 
      glucose or insulin in the present study. Irrespective of MH, dogs adapted RQ to 
      diet composition and dogs consuming the LC diet had a greater incremental AUC for 
      glucose, but not insulin, than dogs consuming the HC diet.
FAU - McKnight, Leslie L
AU  - McKnight LL
AD  - Centre for Nutrition Modelling , Department of Animal and Poultry Science , 
      University of Guelph , 50 Stone Road East , Guelph , Ontario , Canada N1G 2W1.
FAU - Flickinger, Elizabeth A
AU  - Flickinger EA
AD  - Procter and Gamble (P&G) Pet Care , 8700 Mason-Montgomery Road , Mason , OH , 
      45040 , USA.
FAU - France, James
AU  - France J
AD  - Centre for Nutrition Modelling , Department of Animal and Poultry Science , 
      University of Guelph , 50 Stone Road East , Guelph , Ontario , Canada N1G 2W1.
FAU - Davenport, Gary M
AU  - Davenport GM
AD  - Procter and Gamble (P&G) Pet Care , 8700 Mason-Montgomery Road , Mason , OH , 
      45040 , USA.
FAU - Shoveller, Anna K
AU  - Shoveller AK
AD  - Centre for Nutrition Modelling , Department of Animal and Poultry Science , 
      University of Guelph , 50 Stone Road East , Guelph , Ontario , Canada N1G 2W1 ; 
      Procter and Gamble (P&G) Pet Care , 8700 Mason-Montgomery Road , Mason , OH , 
      45040 , USA.
LA  - eng
PT  - Journal Article
DEP - 20140813
PL  - England
TA  - J Nutr Sci
JT  - Journal of nutritional science
JID - 101590587
PMC - PMC4153035
OTO - NOTNLM
OT  - Beagles
OT  - CHO, carbohydrate
OT  - EE, energy expenditure
OT  - ER, energy restriction
OT  - Energy expenditure
OT  - HC, high-carbohydrate (low-fat) diet with mannoheptulose (8 mg/kg)-containing 
      supplement
OT  - HC, high-carbohydrate (low-fat) diet with placebo supplement
OT  - LC, low-carbohydrate (high-fat) diet with mannoheptulose (8 mg/kg)-containing 
      supplement
OT  - LC, low-carbohydrate (high-fat) diet with placebo supplement
OT  - MH, mannoheptulose
OT  - Mannoheptulose
OT  - RQ, respiratory quotient
OT  - Respiratory quotient
OT  - TEF, thermic effect of food
EDAT- 2014/09/06 06:00
MHDA- 2014/09/06 06:01
PMCR- 2014/01/01
CRDT- 2014/09/06 06:00
PHST- 2014/02/28 00:00 [received]
PHST- 2014/04/04 00:00 [revised]
PHST- 2014/06/12 00:00 [accepted]
PHST- 2014/09/06 06:00 [entrez]
PHST- 2014/09/06 06:00 [pubmed]
PHST- 2014/09/06 06:01 [medline]
PHST- 2014/01/01 00:00 [pmc-release]
AID - 00017 [pii]
AID - 10.1017/jns.2014.17 [doi]
PST - epublish
SO  - J Nutr Sci. 2014 Aug 13;3:e17. doi: 10.1017/jns.2014.17. eCollection 2014.