PMID- 25191916
OWN - NLM
STAT- MEDLINE
DCOM- 20141103
LR  - 20180816
IS  - 1555-2101 (Electronic)
IS  - 0160-6689 (Linking)
VI  - 75
IP  - 8
DP  - 2014 Aug
TI  - Combining serum protein concentrations to diagnose schizophrenia: a preliminary 
      exploration.
PG  - e794-801
LID - 10.4088/JCP.13m08772 [doi]
AB  - OBJECTIVE: It is difficult for clinicians to diagnose schizophrenia solely based 
      on interviews. We explored the diagnostic efficiency and predictive capability of 
      serum biomarkers for schizophrenia. METHOD: Levels of beta nerve growth factor 
      (beta-NGF), brain-derived neurotrophic factor (BDNF), interleukin 6 (IL-6), tumor 
      necrosis factor alpha (TNF-alpha), interferon gamma (IFN-gamma), calcium binding protein S100beta, 
      myelin basic protein (MBP), and glial fibrillary acidic protein (GFAP) were 
      measured in the sera of 278 schizophrenia patients, 240 depression and bipolar 
      disorder patients, and 260 healthy controls. DSM-IV-TR criteria were used as the 
      diagnostic criteria for schizophrenia and depressive and bipolar disorders. The 
      diagnostic efficiency was high in patients with schizophrenia compared with the 
      healthy controls. Receiver operating characteristic (ROC) curve analysis was used 
      to ascertain the diagnostic efficiency of the 8 proteins. Data were collected 
      between July 2010 and December 2012. RESULTS: One-way analysis of variance 
      significantly demonstrated lower serum BDNF, MBP, and GFAP levels (F = 16.504, P 
      < .001; F = 207.209, P < .001; F = 33.668, P < .001, respectively) but higher 
      serum IL-6 and S100beta concentrations (F = 15.250, P < .001; F = 12.751, P < .001, 
      respectively) among patients with schizophrenia. ROC analysis of the discriminant 
      scores of the serum beta-NGF, BDNF, IL-6, S100beta, MBP, and GFAP levels resulted in 
      significant discrimination between the schizophrenia and control groups (AUC = 
      0.922) and the depressive/bipolar disorder and control groups (AUC = 0.762). 
      CONCLUSIONS: Serum levels of 6 proteins (but not TNF-alpha and IFN-gamma) contribute most 
      to the diagnosis of schizophrenia. These proteins may prove to be useful adjuncts 
      for the clinical assessment of this disease.
CI  - (c) Copyright 2014 Physicians Postgraduate Press, Inc.
FAU - Xiong, Peng
AU  - Xiong P
AD  - Department of Psychiatry, The First Affiliated Hospital of Kunming Medical 
      University, Kunming, Yunnan, China.
FAU - Zeng, Yong
AU  - Zeng Y
FAU - Wu, Qiuxia
AU  - Wu Q
FAU - Han Huang, Diana Xiao
AU  - Han Huang DX
FAU - Zainal, Hadzlinda
AU  - Zainal H
FAU - Xu, Xiufeng
AU  - Xu X
FAU - Wan, Jing
AU  - Wan J
FAU - Xu, Fei
AU  - Xu F
FAU - Lu, Jin
AU  - Lu J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Clin Psychiatry
JT  - The Journal of clinical psychiatry
JID - 7801243
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - 0 (Interleukin-6)
RN  - 0 (Myelin Basic Protein)
RN  - 0 (S100 Calcium Binding Protein beta Subunit)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - 82115-62-6 (Interferon-gamma)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Bipolar Disorder/blood
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Case-Control Studies
MH  - Depressive Disorder/blood/diagnosis
MH  - Female
MH  - Glial Fibrillary Acidic Protein/*blood
MH  - Humans
MH  - Interferon-gamma/*blood
MH  - Interleukin-6/*blood
MH  - Male
MH  - Myelin Basic Protein/*blood
MH  - Nerve Growth Factor/*blood
MH  - Psychiatric Status Rating Scales
MH  - ROC Curve
MH  - S100 Calcium Binding Protein beta Subunit/*blood
MH  - Schizophrenia/*blood/*diagnosis
MH  - Tumor Necrosis Factor-alpha/*blood
MH  - Young Adult
EDAT- 2014/09/06 06:00
MHDA- 2014/11/05 06:00
CRDT- 2014/09/06 06:00
PHST- 2013/09/01 00:00 [received]
PHST- 2014/02/24 00:00 [accepted]
PHST- 2014/09/06 06:00 [entrez]
PHST- 2014/09/06 06:00 [pubmed]
PHST- 2014/11/05 06:00 [medline]
AID - 10.4088/JCP.13m08772 [doi]
PST - ppublish
SO  - J Clin Psychiatry. 2014 Aug;75(8):e794-801. doi: 10.4088/JCP.13m08772.