PMID- 25192895
OWN - NLM
STAT- MEDLINE
DCOM- 20160519
LR  - 20221207
IS  - 1573-4978 (Electronic)
IS  - 0301-4851 (Linking)
VI  - 41
IP  - 12
DP  - 2014 Dec
TI  - Association of IL-18 promoter gene polymorphisms with rheumatoid arthritis: a 
      meta-analysis.
PG  - 8211-7
LID - 10.1007/s11033-014-3723-3 [doi]
AB  - Interleukin-18(IL-18) plays a potential pathological role in rheumatoid arthritis 
      (RA). The conclusions of the published reports on the relationship between 
      single-nucleotide polymorphisms -607C/A (rs1946518) and -137G/C (rs187238) 
      located in the IL-18 gene promoter and RA risk remain controversial. This 
      meta-analysis was performed to evaluate the association between IL-18 gene 
      promoter (-607A/C and -137C/G) polymorphisms and RA using (1) allele, (2) 
      codominant, (3) dominant, and (4) recessive models. Literature search was 
      conducted up to January, 2013, in PubMed, EMBASE, Spring-link, Web of Science, 
      Wanfang (Chinese) and China National Knowledge Infrastructure (CNKI). A total of 
      10 studies from eight articles involving 2,662 cases and 2,168 controls for 
      -607A/C polymorphism and 9 studies from six articles involving 1,331 cases and 
      1,468 controls for -137C/G polymorphism were considered in the meta-analysis. For 
      the relationship of IL-18 -607A/C polymorphism with RA risk, significant 
      association was observed in allele model (OR = 0.778, 95 % CI = 0.633-0.955) and 
      dominant model (OR = 0.618, 95 % CI = 0.466-0.819). However, no significant 
      association could be observed between -137C/G polymorphism and RA risk under all 
      genetic models (allele model: OR = 0.940, 95 % CI = 0.777-1.138; codominant 
      model: OR = 1.079, 95 % CI = 0.574-2.029; dominant model: OR = 0.913, 95 % CI = 
      0.779-1.069; recessive model: OR = 1.133, 95 % CI = 0.586-2.190). In the subgroup 
      analysis by ethnicity, significant result was also found in Asian populations but 
      not found in Caucasian populations for the relationship of IL-18 -607A/C 
      polymorphism with RA risk; while no obvious association was found between IL-18 
      -137C/G polymorphism and RA risk. This meta-analysis indicates that IL-18 -607A/C 
      polymorphism in promoter region may be associated with RA risk.
FAU - Cai, Li-Ping
AU  - Cai LP
AD  - Department of Pharmacy, People's Hospital of Beihai, Beihai, China.
FAU - Zhou, Li-Juan
AU  - Zhou LJ
FAU - Lu, Shun-Yu
AU  - Lu SY
FAU - Liang, Ying-E
AU  - Liang YE
FAU - Chen, Xiao-Ying
AU  - Chen XY
FAU - Liu, Lin
AU  - Liu L
FAU - Lin, Jun
AU  - Lin J
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20140906
PL  - Netherlands
TA  - Mol Biol Rep
JT  - Molecular biology reports
JID - 0403234
RN  - 0 (IL18 protein, human)
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Alleles
MH  - Arthritis, Rheumatoid/*ethnology/*genetics
MH  - Asian People/genetics
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Interleukin-18/*genetics
MH  - *Polymorphism, Single Nucleotide
MH  - Promoter Regions, Genetic
MH  - White People/genetics
EDAT- 2014/09/07 06:00
MHDA- 2016/05/20 06:00
CRDT- 2014/09/07 06:00
PHST- 2013/02/06 00:00 [received]
PHST- 2014/08/28 00:00 [accepted]
PHST- 2014/09/07 06:00 [entrez]
PHST- 2014/09/07 06:00 [pubmed]
PHST- 2016/05/20 06:00 [medline]
AID - 10.1007/s11033-014-3723-3 [doi]
PST - ppublish
SO  - Mol Biol Rep. 2014 Dec;41(12):8211-7. doi: 10.1007/s11033-014-3723-3. Epub 2014 
      Sep 6.