PMID- 25193130
OWN - NLM
STAT- MEDLINE
DCOM- 20150731
LR  - 20141206
IS  - 1878-4216 (Electronic)
IS  - 0278-5846 (Linking)
VI  - 56
DP  - 2015 Jan 2
TI  - The role of neurotrophins in bipolar disorder.
PG  - 122-8
LID - S0278-5846(14)00163-8 [pii]
LID - 10.1016/j.pnpbp.2014.08.013 [doi]
AB  - Bipolar disorder (BD) is a chronic psychiatric illness of which the 
      pathophysiology remains partially unknown. Abnormalities of neurotrophins and 
      other trophic factors orchestrate important alterations which could be implicated 
      in the etiology of BD. Therefore, the main objective of this review is to examine 
      the recent findings and critically evaluate the potential role of neurotrophins 
      that may allow us to substantially improve the development of novel treatments. 
      The most recently published findings highlight that brain-derived neurotrophic 
      factor (BDNF), insulin-like growth factor (IGF-1) and vascular endothelial growth 
      factor (VEGF) present distinct patterns in the different stages of BD, suggesting 
      their potential in the identification of the BD subgroups and may ultimately 
      advance treatment strategies.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Scola, Gustavo
AU  - Scola G
AD  - Department of Psychiatry, University of Toronto, 1 King's College Circle, 
      Toronto, ON, M5S 1A8, Canada; Centre for Addiction and Mental Health, 250 College 
      Street, Toronto, ON, M5T 1R8, Canada. Electronic address: 
      gustavo.scola@utoronto.ca.
FAU - Andreazza, Ana Cristina
AU  - Andreazza AC
AD  - Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, M5T 1R8, 
      Canada; Department of Pharmacology and Department of Psychiatry, University of 
      Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada. Electronic 
      address: ana.andreazza@utoronto.ca.
LA  - eng
GR  - MOP 133439/Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20140902
PL  - England
TA  - Prog Neuropsychopharmacol Biol Psychiatry
JT  - Progress in neuro-psychopharmacology & biological psychiatry
JID - 8211617
RN  - 0 (Nerve Growth Factors)
SB  - IM
MH  - Bipolar Disorder/*metabolism
MH  - Humans
MH  - Nerve Growth Factors/*metabolism
OTO - NOTNLM
OT  - Bipolar disorder
OT  - Glial cell line-derived neurotrophic factor
OT  - Insulin-like growth factor-1
OT  - Neurotrophins
OT  - Vascular endothelial growth factor
EDAT- 2014/09/07 06:00
MHDA- 2015/08/01 06:00
CRDT- 2014/09/07 06:00
PHST- 2014/06/26 00:00 [received]
PHST- 2014/08/25 00:00 [revised]
PHST- 2014/08/26 00:00 [accepted]
PHST- 2014/09/07 06:00 [entrez]
PHST- 2014/09/07 06:00 [pubmed]
PHST- 2015/08/01 06:00 [medline]
AID - S0278-5846(14)00163-8 [pii]
AID - 10.1016/j.pnpbp.2014.08.013 [doi]
PST - ppublish
SO  - Prog Neuropsychopharmacol Biol Psychiatry. 2015 Jan 2;56:122-8. doi: 
      10.1016/j.pnpbp.2014.08.013. Epub 2014 Sep 2.