PMID- 25193530
OWN - NLM
STAT- MEDLINE
DCOM- 20150427
LR  - 20181202
IS  - 1935-5548 (Electronic)
IS  - 0149-5992 (Linking)
VI  - 37
IP  - 11
DP  - 2014 Nov
TI  - Longitudinal development of left ventricular diastolic function in patients with 
      type 2 diabetes.
PG  - 3092-7
LID - 10.2337/dc14-0779 [doi]
AB  - OBJECTIVE: Left ventricular diastolic dysfunction (LVDD) is considered to be 
      common in patients with type 2 diabetes mellitus (T2DM), but information on its 
      progression over time is lacking. We studied the longitudinal development of left 
      ventricular diastolic function (LVDF) and myocardial blood flow reserve in 
      patients with T2DM who were free from clinically detectable cardiovascular 
      disease. RESEARCH DESIGN AND METHODS: The LVDF was assessed in 73 patients with 
      T2DM (mean age 67 +/- 7 years; males 51%) on two occasions separated by 6.4 +/- 0.8 
      years. RESULTS: At baseline, LVDD was observed in 23 of the patients (32%). 
      During follow-up, the LVDF normalized in 10 of these patients (43%) and remained 
      unchanged in 13 of them (57%). Of the 50 patients (68%) with normal LVDF at 
      baseline, LVDD developed in 9 (18%). Paired evaluation of myocardial blood volume 
      index was available from 22 patients with LVDD and remained unchanged over time. 
      CONCLUSIONS: The condition of the majority of the investigated patients with LVDD 
      improved or remained stable over a period of 6 years.
CI  - (c) 2014 by the American Diabetes Association. Readers may use this article as long 
      as the work is properly cited, the use is educational and not for profit, and the 
      work is not altered.
FAU - Venskutonyte, Laura
AU  - Venskutonyte L
AD  - Cardiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden 
      laura.venskutonyte@ki.se.
FAU - Jarnert, Christina
AU  - Jarnert C
AD  - Cardiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, 
      Sweden.
FAU - Ryden, Lars
AU  - Ryden L
AD  - Cardiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, 
      Sweden.
FAU - Kjellstrom, Barbro
AU  - Kjellstrom B
AD  - Cardiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, 
      Sweden.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140905
PL  - United States
TA  - Diabetes Care
JT  - Diabetes care
JID - 7805975
SB  - IM
CIN - Diabetes Care. 2015 Apr;38(4):e62-3. PMID: 25805876
MH  - Aged
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Diastole
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Ventricular Dysfunction, Left/*epidemiology/etiology/physiopathology
MH  - Ventricular Function, Left/*physiology
EDAT- 2014/09/07 06:00
MHDA- 2015/04/29 06:00
CRDT- 2014/09/07 06:00
PHST- 2014/09/07 06:00 [entrez]
PHST- 2014/09/07 06:00 [pubmed]
PHST- 2015/04/29 06:00 [medline]
AID - dc14-0779 [pii]
AID - 10.2337/dc14-0779 [doi]
PST - ppublish
SO  - Diabetes Care. 2014 Nov;37(11):3092-7. doi: 10.2337/dc14-0779. Epub 2014 Sep 5.