PMID- 25193852
OWN - NLM
STAT- MEDLINE
DCOM- 20150720
LR  - 20220317
IS  - 1535-3699 (Electronic)
IS  - 1535-3702 (Print)
IS  - 1535-3699 (Linking)
VI  - 240
IP  - 4
DP  - 2015 Apr
TI  - Alpha-lipoic acid affects the oxidative stress in various brain structures in 
      mice with methionine and choline deficiency.
PG  - 418-25
LID - 10.1177/1535370214549521 [doi]
AB  - Deficiency in methionine or choline can induce oxidative stress in various organs 
      such as liver, kidney, heart, and brain. This study was to examine the effects of 
      alpha-lipoic acid (LA) on oxidative stress induced by methionine and choline 
      deficiency (MCD) in several brain structures. Male mice C57BL/6 (n = 28) were 
      divided into four groups: (1) control - continuously fed with standard chow; (2) 
      LA - fed with standard chow and receiving LA; (3) MCD2 - fed with MCD diet for 
      two weeks, and (4) MCD2+LA - fed with MCD diet for two weeks and receiving LA 
      (100 mg/kg/day intraperitonealy [i.p.]). Brain tissue (cortex, hypothalamus, 
      striatum and hippocampus) was taken for determination of oxidative stress 
      parameters. MCD diet induced a significant increase in malondialdehyde and NOx 
      concentration in all brain regions, while LA restored their content to normal 
      values. Similar to this, in MCD2 group, activity of total SOD, MnSOD, and 
      Cu/ZnSOD was reduced by MCD diet, while LA treatment improved their activities in 
      all brain structures. Besides, in MCD2 group a decrease in catalase activity in 
      cortex and GSH content in hypothalamus was evident, while LA treatment induced an 
      increase in catalase activity in cortex and striatum and GSH content in 
      hypothalamus. LA treatment can significantly reduce lipid peroxidation and 
      nitrosative stress, caused by MCD diet, in all brain regions by restoring 
      antioxidant enzymes activities, predominantly total SOD, MnSOD, and Cu/ZnSOD, and 
      to a lesser extent by modulating catalase activity and GSH content. LA 
      supplementation may be used in order to prevent brain oxidative injury induced by 
      methionine and choline deficiency.
CI  - (c) 2014 by the Society for Experimental Biology and Medicine.
FAU - Veskovic, Milena
AU  - Veskovic M
AD  - Institute of Pathophysiology "Ljubodrag Buba Mihailovic", Faculty of Medicine, 
      University of Belgrade, 11000 Belgrade, Serbia.
FAU - Mladenovic, Dusan
AU  - Mladenovic D
AD  - Institute of Pathophysiology "Ljubodrag Buba Mihailovic", Faculty of Medicine, 
      University of Belgrade, 11000 Belgrade, Serbia.
FAU - Jorgacevic, Bojan
AU  - Jorgacevic B
AD  - Institute of Pathophysiology "Ljubodrag Buba Mihailovic", Faculty of Medicine, 
      University of Belgrade, 11000 Belgrade, Serbia.
FAU - Stevanovic, Ivana
AU  - Stevanovic I
AD  - Millitary Medical Academy, 11000 Belgrade, Serbia.
FAU - de Luka, Silvio
AU  - de Luka S
AD  - Institute of Pathophysiology "Ljubodrag Buba Mihailovic", Faculty of Medicine, 
      University of Belgrade, 11000 Belgrade, Serbia.
FAU - Radosavljevic, Tatjana
AU  - Radosavljevic T
AD  - Institute of Pathophysiology "Ljubodrag Buba Mihailovic", Faculty of Medicine, 
      University of Belgrade, 11000 Belgrade, Serbia tanjamm@med.bg.ac.rs.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140905
PL  - Switzerland
TA  - Exp Biol Med (Maywood)
JT  - Experimental biology and medicine (Maywood, N.J.)
JID - 100973463
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - 73Y7P0K73Y (Thioctic Acid)
RN  - AE28F7PNPL (Methionine)
RN  - EC 1.11.1.6 (Catalase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - GAN16C9B8O (Glutathione)
SB  - IM
MH  - Animals
MH  - Brain/*metabolism
MH  - Catalase/metabolism
MH  - Cerebral Cortex/drug effects/*metabolism
MH  - Choline Deficiency/*metabolism
MH  - Corpus Striatum/drug effects/*metabolism
MH  - Disease Models, Animal
MH  - Glutathione/metabolism
MH  - Hippocampus/drug effects/metabolism
MH  - Hypothalamus/drug effects/*metabolism
MH  - Lipid Peroxidation/drug effects
MH  - Male
MH  - Malondialdehyde/metabolism
MH  - Methionine/*deficiency/metabolism
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Nitric Oxide/metabolism
MH  - Oxidative Stress/*drug effects
MH  - Superoxide Dismutase/metabolism
MH  - Thioctic Acid/*pharmacology
PMC - PMC4935381
OTO - NOTNLM
OT  - Methionine and choline deficient diet
OT  - lipid peroxidation
OT  - lipoic acid
OT  - nitrosative stress
OT  - oxidative stress
EDAT- 2014/09/07 06:00
MHDA- 2015/07/21 06:00
PMCR- 2015/10/01
CRDT- 2014/09/07 06:00
PHST- 2014/04/17 00:00 [received]
PHST- 2014/07/30 00:00 [accepted]
PHST- 2014/09/07 06:00 [entrez]
PHST- 2014/09/07 06:00 [pubmed]
PHST- 2015/07/21 06:00 [medline]
PHST- 2015/10/01 00:00 [pmc-release]
AID - 1535370214549521 [pii]
AID - 10.1177_1535370214549521 [pii]
AID - 10.1177/1535370214549521 [doi]
PST - ppublish
SO  - Exp Biol Med (Maywood). 2015 Apr;240(4):418-25. doi: 10.1177/1535370214549521. 
      Epub 2014 Sep 5.