PMID- 25193877
OWN - NLM
STAT- MEDLINE
DCOM- 20150511
LR  - 20181202
IS  - 1873-5487 (Electronic)
IS  - 0188-4409 (Linking)
VI  - 45
IP  - 6
DP  - 2014 Aug
TI  - Increase in the risk of ST elevation myocardial infarction is associated with 
      homocysteine level.
PG  - 501-6
LID - S0188-4409(14)00176-3 [pii]
LID - 10.1016/j.arcmed.2014.08.003 [doi]
AB  - BACKGROUND AND AIMS: The present study aimed to investigate the relationship 
      between coagulation defects and ST elevation myocardial infarction (STEMI) in 
      patients without any known coronary artery risk factors and considered low risk 
      according to the Framingham risk classification. METHODS: This study included 76 
      (73.6% male) STEMI patients without any known risk factors for coronary artery 
      disease and 56 healthy controls (67.8% male) with similar characteristics. 
      RESULTS: Factor V Leiden mutation was noted in two patients and in one control. 
      There were no significant differences in protein C, protein S, or antithrombin 3 
      values between the patient and control groups (p = 0.405, p = 0.476, and 
      p = 0.221, respectively). None of the participants had antiphospholipid syndrome, 
      factor V deficiency, or factor VII deficiency. Plasma homocysteine level was 
      significantly higher in the patient group (19.0 +/- 3.6) mumol/L than in the control 
      group (15.8 +/- 4.2) mumol/L (p = 0.008). Homocysteine levels in both groups were 
      higher in males without a statistically significant difference. Vitamin B12 and 
      folate levels, which are directly related to homocysteine metabolism, did not 
      differ significantly between groups. Correlation analysis showed that the 
      homocysteine level was not correlated with lipid parameters, folate, or vitamin 
      B12. CONCLUSION: Homocysteine level was significantly higher in acute MI in 
      patients without any risk factors and were considered low risk according to the 
      Framingham risk score. The findings support the hypothesis that homocysteine 
      level may be an independent risk factor for coronary artery disease.
CI  - Copyright (c) 2014 IMSS. Published by Elsevier Inc. All rights reserved.
FAU - Akyurek, Omer
AU  - Akyurek O
AD  - Department of Internal Medicine, Mevlana University Faculty of Medicine, Konya, 
      Turkey. Electronic address: dromerakyurek@gmail.com.
FAU - Akbal, Erdem
AU  - Akbal E
AD  - Department of Gastroenterology, Canakkale Onsekiz Mart University, Canakkale, 
      Turkey.
FAU - Gunes, Fahri
AU  - Gunes F
AD  - Department of Internal Medicine, Canakkale Onsekiz Mart University, Canakkale, 
      Turkey.
LA  - eng
PT  - Journal Article
DEP - 20140902
PL  - United States
TA  - Arch Med Res
JT  - Archives of medical research
JID - 9312706
RN  - 0 (Biomarkers)
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 935E97BOY8 (Folic Acid)
RN  - P6YC3EG204 (Vitamin B 12)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - Female
MH  - Folic Acid/blood
MH  - Homocysteine/*blood
MH  - Humans
MH  - Linear Models
MH  - Male
MH  - Myocardial Infarction/blood/*etiology
MH  - Risk Assessment
MH  - Risk Factors
MH  - Vitamin B 12/blood
OTO - NOTNLM
OT  - Homocysteine
OT  - STEMI
EDAT- 2014/09/07 06:00
MHDA- 2015/05/12 06:00
CRDT- 2014/09/07 06:00
PHST- 2014/05/09 00:00 [received]
PHST- 2014/08/20 00:00 [accepted]
PHST- 2014/09/07 06:00 [entrez]
PHST- 2014/09/07 06:00 [pubmed]
PHST- 2015/05/12 06:00 [medline]
AID - S0188-4409(14)00176-3 [pii]
AID - 10.1016/j.arcmed.2014.08.003 [doi]
PST - ppublish
SO  - Arch Med Res. 2014 Aug;45(6):501-6. doi: 10.1016/j.arcmed.2014.08.003. Epub 2014 
      Sep 2.