PMID- 25194280 OWN - NLM STAT- MEDLINE DCOM- 20141215 LR - 20221207 IS - 1546-1718 (Electronic) IS - 1061-4036 (Linking) VI - 46 IP - 10 DP - 2014 Oct TI - Genome-wide association study identifies three susceptibility loci for laryngeal squamous cell carcinoma in the Chinese population. PG - 1110-4 LID - 10.1038/ng.3090 [doi] AB - To identify genetic markers for laryngeal squamous cell carcinoma (LSCC), we conducted a genome-wide association study (GWAS) on 993 individuals with LSCC (cases) and 1,995 cancer-free controls from Chinese populations. The most promising variants (association P < 1 x 10(-5)) were then replicated in 3 independent sets including 2,398 cases and 2,804 controls, among which we identified 3 new susceptibility loci at 11q12 (rs174549), 6p21 (rs2857595) and 12q24 (rs10492336). The minor alleles of each of these loci showed protective effects, with odds ratios (95% confidence intervals) of 0.73 (0.68-0.78; P = 1.00 x 10(-20)), 0.78 (0.72-0.84; P = 2.43 x 10(-15)) and 0.71 (0.65-0.77; P = 4.48 x 10(-14)), respectively. None of these variants showed an interaction with smoking or drinking. This is the first GWAS to our knowledge solely on LSCC, and the findings might advance understanding of the etiology of LSCC. FAU - Wei, Qingyi AU - Wei Q AD - 1] Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, China. [2] Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. [3] Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA. [4] [5]. FAU - Yu, Dianke AU - Yu D AD - 1] State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. [2]. FAU - Liu, Mingbo AU - Liu M AD - 1] Department of Otolaryngology-Head and Neck Surgery, Chinese People's Liberation Army General Hospital, Beijing, China. [2]. FAU - Wang, Mengyun AU - Wang M AD - 1] Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, China. [2] Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA. [3]. FAU - Zhao, Miaoqing AU - Zhao M AD - Department of Pathology, Provincial Hospital affiliated to Shandong University, Jinan, China. FAU - Liu, Ming AU - Liu M AD - Department of Otorhinolaryngology and Head and Neck Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China. FAU - Jia, Weihua AU - Jia W AD - State Key Laboratory of Oncology in Southern China, Sun Yat-Sen University Cancer Center, Guangzhou, China. FAU - Ma, Hongxia AU - Ma H AD - Department of Epidemiology and Biostatistics, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, School of Public Health, Nanjing Medical University, Nanjing, China. FAU - Fang, Jugao AU - Fang J AD - Department of Otolaryngology-Head and Neck Surgery, Affiliated Beijing Tongren Hospital, Capital University of Medical Sciences, Beijing, China. FAU - Xu, Wei AU - Xu W AD - Department of Otolaryngology-Head and Neck Surgery, Provincial Hospital affiliated to Shandong University, Jinan, China. FAU - Chen, Kexing AU - Chen K AD - Department of Epidemiology and Biostatistics, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China. FAU - Xu, Zhengang AU - Xu Z AD - Department of Head and Neck Surgical Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. FAU - Wang, Jialing AU - Wang J AD - Department of Otolaryngology-Head and Neck Surgery, Chinese People's Liberation Army General Hospital, Beijing, China. FAU - Tian, Linli AU - Tian L AD - Department of Otorhinolaryngology and Head and Neck Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China. FAU - Yuan, Hua AU - Yuan H AD - Department of Epidemiology and Biostatistics, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, School of Public Health, Nanjing Medical University, Nanjing, China. FAU - Chang, Jiang AU - Chang J AD - State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. FAU - Hu, Zhibin AU - Hu Z AD - Department of Epidemiology and Biostatistics, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, School of Public Health, Nanjing Medical University, Nanjing, China. FAU - Wei, Lixun AU - Wei L AD - State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. FAU - Huang, Ying AU - Huang Y AD - State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. FAU - Han, Yaling AU - Han Y AD - State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. FAU - Liu, Jie AU - Liu J AD - Department of Head and Neck Surgical Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. FAU - Han, Demin AU - Han D AD - Department of Otolaryngology-Head and Neck Surgery, Affiliated Beijing Tongren Hospital, Capital University of Medical Sciences, Beijing, China. FAU - Shen, Hongbing AU - Shen H AD - Department of Epidemiology and Biostatistics, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, School of Public Health, Nanjing Medical University, Nanjing, China. FAU - Yang, Shiming AU - Yang S AD - Department of Otolaryngology-Head and Neck Surgery, Chinese People's Liberation Army General Hospital, Beijing, China. FAU - Zheng, Hong AU - Zheng H AD - Department of Epidemiology and Biostatistics, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China. FAU - Ji, Qinghai AU - Ji Q AD - Department of Head and Neck Surgery, Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, China. FAU - Li, Duanshu AU - Li D AD - Department of Head and Neck Surgery, Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, China. FAU - Tan, Wen AU - Tan W AD - State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. FAU - Wu, Chen AU - Wu C AD - State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. FAU - Lin, Dongxin AU - Lin D AD - State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20140907 PL - United States TA - Nat Genet JT - Nature genetics JID - 9216904 SB - IM MH - Aged MH - Asian People/genetics MH - Carcinoma, Squamous Cell/ethnology/*genetics MH - China MH - Chromosomes, Human, Pair 11/genetics MH - Chromosomes, Human, Pair 12/genetics MH - Chromosomes, Human, Pair 6/genetics MH - Esophageal Neoplasms/ethnology/*genetics MH - Female MH - Gene Frequency MH - Genetic Loci/*genetics MH - Genetic Predisposition to Disease/etiology/*genetics MH - *Genome-Wide Association Study MH - Genotype MH - Humans MH - Linkage Disequilibrium MH - Male MH - Middle Aged MH - Polymorphism, Single Nucleotide EDAT- 2014/09/10 06:00 MHDA- 2014/12/17 06:00 CRDT- 2014/09/08 06:00 PHST- 2013/07/13 00:00 [received] PHST- 2014/08/15 00:00 [accepted] PHST- 2014/09/08 06:00 [entrez] PHST- 2014/09/10 06:00 [pubmed] PHST- 2014/12/17 06:00 [medline] AID - ng.3090 [pii] AID - 10.1038/ng.3090 [doi] PST - ppublish SO - Nat Genet. 2014 Oct;46(10):1110-4. doi: 10.1038/ng.3090. Epub 2014 Sep 7.