PMID- 25196123
OWN - NLM
STAT- MEDLINE
DCOM- 20150619
LR  - 20161125
IS  - 1366-5804 (Electronic)
IS  - 1354-750X (Linking)
VI  - 19
IP  - 7
DP  - 2014 Nov
TI  - Circulating chemokines in relation to coronary plaque characteristics on 
      radiofrequency intravascular ultrasound and cardiovascular outcome.
PG  - 611-9
LID - 10.3109/1354750X.2014.957725 [doi]
AB  - OBJECTIVE: To investigate relations of several circulating chemokines with extent 
      and phenotype of coronary atherosclerosis and with 1-year clinical outcome. 
      METHODS: Intravascular ultrasound virtual histology (IVUS-VH) imaging of a 
      coronary artery was performed in 581 patients. Monocyte chemoattractant protein-1 
      (MCP-1), macrophage inflammatory protein-1alpha (MIP-1alpha), MIP-1beta and regulated upon 
      activation normal T cell expressed and secreted (RANTES) were measured in plasma. 
      RESULTS: Higher MCP-1, MIP-1alpha and lower RANTES were associated with coronary 
      plaque burden. Higher MCP-1, MIP-1alpha and lower RANTES were associated with the 
      presence of IVUS-VH-derived thin-cap fibroatheroma lesions. RANTES was associated 
      with major adverse cardiac events. CONCLUSIONS: RANTES is a promising biomarker 
      that is inversely associated with coronary plaque burden and vulnerability, as 
      well as with death and acute coronary syndrome.
FAU - Cheng, Jin M
AU  - Cheng JM
AD  - Erasmus MC, Department of Cardiology , Rotterdam , the Netherlands and.
FAU - Oemrawsingh, Rohit M
AU  - Oemrawsingh RM
FAU - Akkerhuis, K Martijn
AU  - Akkerhuis KM
FAU - Garcia-Garcia, Hector M
AU  - Garcia-Garcia HM
FAU - de Boer, Sanneke P M
AU  - de Boer SP
FAU - Battes, Linda C
AU  - Battes LC
FAU - Buljubasic, Nermina
AU  - Buljubasic N
FAU - Lenzen, Mattie J
AU  - Lenzen MJ
FAU - de Jaegere, Peter P T
AU  - de Jaegere PP
FAU - van Geuns, Robert-Jan
AU  - van Geuns RJ
FAU - Serruys, Patrick W
AU  - Serruys PW
FAU - Kardys, Isabella
AU  - Kardys I
FAU - Boersma, Eric
AU  - Boersma E
LA  - eng
SI  - ClinicalTrials.gov/NCT01789411
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140908
PL  - England
TA  - Biomarkers
JT  - Biomarkers : biochemical indicators of exposure, response, and susceptibility to 
      chemicals
JID - 9606000
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (CCL3 protein, human)
RN  - 0 (CCL4 protein, human)
RN  - 0 (CCL5 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CCL3)
RN  - 0 (Chemokine CCL4)
RN  - 0 (Chemokine CCL5)
RN  - 0 (Chemokines)
SB  - IM
MH  - Aged
MH  - Biomarkers/blood
MH  - Chemokine CCL2/blood
MH  - Chemokine CCL3/blood
MH  - Chemokine CCL4/blood
MH  - Chemokine CCL5/blood
MH  - Chemokines/*blood
MH  - Coronary Artery Disease/*blood/*diagnostic imaging/mortality/therapy
MH  - Coronary Vessels/*diagnostic imaging
MH  - Female
MH  - Fibrosis
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Middle Aged
MH  - Necrosis
MH  - *Plaque, Atherosclerotic
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Prospective Studies
MH  - Time Factors
MH  - *Ultrasonography, Interventional
OTO - NOTNLM
OT  - Atherosclerosis
OT  - biomarker
OT  - chemokines
OT  - intravascular ultrasound
OT  - prognosis
EDAT- 2014/09/10 06:00
MHDA- 2015/06/20 06:00
CRDT- 2014/09/09 06:00
PHST- 2014/09/09 06:00 [entrez]
PHST- 2014/09/10 06:00 [pubmed]
PHST- 2015/06/20 06:00 [medline]
AID - 10.3109/1354750X.2014.957725 [doi]
PST - ppublish
SO  - Biomarkers. 2014 Nov;19(7):611-9. doi: 10.3109/1354750X.2014.957725. Epub 2014 
      Sep 8.