PMID- 25196192
OWN - NLM
STAT- MEDLINE
DCOM- 20160303
LR  - 20211021
IS  - 1864-0648 (Electronic)
IS  - 1864-063X (Print)
IS  - 1864-063X (Linking)
VI  - 8
IP  - 6
DP  - 2015 Jun
TI  - Low-level laser therapy for traumatic brain injury in mice increases brain 
      derived neurotrophic factor (BDNF) and synaptogenesis.
PG  - 502-11
LID - 10.1002/jbio.201400069 [doi]
AB  - Transcranial low-level laser (light) therapy (LLLT) is a new non-invasive 
      approach to treating a range of brain disorders including traumatic brain injury 
      (TBI). We (and others) have shown that applying near-infrared light to the head 
      of animals that have suffered TBI produces improvement in neurological 
      functioning, lessens the size of the brain lesion, reduces neuroinflammation, and 
      stimulates the formation of new neurons. In the present study we used a 
      controlled cortical impact TBI in mice and treated the mice either once (4 h 
      post-TBI, 1-laser), or three daily applications (3-laser) with 810 nm CW laser 36 
      J/cm(2) at 50 mW/cm(2). Similar to previous studies, the neurological severity 
      score improved in laser-treated mice compared to untreated TBI mice at day 14 and 
      continued to further improve at days 21 and 28 with 3-laser being better than 
      1-laser. Mice were sacrificed at days 7 and 28 and brains removed for 
      immunofluorescence analysis. Brain-derived neurotrophic factor (BDNF) was 
      significantly upregulated by laser treatment in the dentate gyrus of the 
      hippocampus (DG) and the subventricular zone (SVZ) but not in the perilesional 
      cortex (lesion) at day 7 but not at day 28. Synapsin-1 (a marker for 
      synaptogenesis, the formation of new connections between existing neurons) was 
      significantly upregulated in lesion and SVZ but not DG, at 28 days but not 7 
      days. The data suggest that the benefit of LLLT to the brain is partly mediated 
      by stimulation of BDNF production, which may in turn encourage synaptogenesis. 
      Moreover the pleiotropic benefits of BDNF in the brain suggest LLLT may have 
      wider applications to neurodegenerative and psychiatric disorders. Neurological 
      Severity Score (NSS) for TBI mice.
CI  - (c) 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
FAU - Xuan, Weijun
AU  - Xuan W
AD  - Wellman Center for Photomedicine, Massachusetts General Hospital, 40 Blossom 
      Street, Boston, MA 02114, USA.
AD  - Department of Dermatology, Harvard Medical School, Boston, MA 02115, USA.
AD  - Department of Otolaryngology, Traditional Chinese Medical University of Guangxi, 
      Nanning, China.
FAU - Agrawal, Tanupriya
AU  - Agrawal T
AD  - Department of Dermatology, Harvard Medical School, Boston, MA 02115, USA.
AD  - Department of Otolaryngology, Traditional Chinese Medical University of Guangxi, 
      Nanning, China.
FAU - Huang, Liyi
AU  - Huang L
AD  - Department of Dermatology, Harvard Medical School, Boston, MA 02115, USA.
AD  - Department of Otolaryngology, Traditional Chinese Medical University of Guangxi, 
      Nanning, China.
AD  - Department of Infectious Diseases, First Affiliated College & Hospital, Guangxi 
      Medical University, Nanning, 530021, China.
FAU - Gupta, Gaurav K
AU  - Gupta GK
AD  - Department of Dermatology, Harvard Medical School, Boston, MA 02115, USA.
AD  - Department of Otolaryngology, Traditional Chinese Medical University of Guangxi, 
      Nanning, China.
AD  - Department of Pathology and Laboratory Medicine, Tufts Medical Center, Boston, MA 
      02111, USA.
FAU - Hamblin, Michael R
AU  - Hamblin MR
AD  - Department of Dermatology, Harvard Medical School, Boston, MA 02115, USA. 
      hamblin@helix.mgh.harvard.edu.
AD  - Department of Otolaryngology, Traditional Chinese Medical University of Guangxi, 
      Nanning, China. hamblin@helix.mgh.harvard.edu.
AD  - Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA 02139, USA. 
      hamblin@helix.mgh.harvard.edu.
LA  - eng
GR  - R01 AI050875/AI/NIAID NIH HHS/United States
GR  - R01AI050875/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20140908
PL  - Germany
TA  - J Biophotonics
JT  - Journal of biophotonics
JID - 101318567
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Synapsins)
SB  - IM
MH  - Animals
MH  - Brain Injuries/physiopathology/*radiotherapy
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Dentate Gyrus/metabolism/*radiation effects
MH  - Disease Models, Animal
MH  - Fluorescent Antibody Technique
MH  - Lateral Ventricles/metabolism/*radiation effects
MH  - Low-Level Light Therapy/*methods
MH  - Male
MH  - Mice, Inbred BALB C
MH  - Severity of Illness Index
MH  - Synapses/metabolism/radiation effects
MH  - Synapsins/*metabolism
MH  - Treatment Outcome
PMC - PMC5379854
MID - NIHMS638027
OTO - NOTNLM
OT  - BDNF
OT  - Synapsin-1
OT  - neurogenesis
OT  - synaptogenesis
OT  - transcranial low level light therapy
OT  - traumatic brain injury
EDAT- 2014/09/10 06:00
MHDA- 2016/03/05 06:00
PMCR- 2017/04/04
CRDT- 2014/09/09 06:00
PHST- 2014/06/25 00:00 [received]
PHST- 2014/07/22 00:00 [revised]
PHST- 2014/07/24 00:00 [accepted]
PHST- 2014/09/09 06:00 [entrez]
PHST- 2014/09/10 06:00 [pubmed]
PHST- 2016/03/05 06:00 [medline]
PHST- 2017/04/04 00:00 [pmc-release]
AID - 10.1002/jbio.201400069 [doi]
PST - ppublish
SO  - J Biophotonics. 2015 Jun;8(6):502-11. doi: 10.1002/jbio.201400069. Epub 2014 Sep 
      8.