PMID- 25196377
OWN - NLM
STAT- MEDLINE
DCOM- 20150612
LR  - 20171116
IS  - 1521-186X (Electronic)
IS  - 0197-8462 (Linking)
VI  - 35
IP  - 7
DP  - 2014 Oct
TI  - Multigenerational effects of whole body exposure to 2.14 GHz W-CDMA cellular 
      phone signals on brain function in rats.
PG  - 497-511
LID - 10.1002/bem.21871 [doi]
AB  - The present experimental study was carried out with rats to evaluate the effects 
      of whole body exposure to 2.14 GHz band code division multiple access (W-CDMA) 
      signals for 20 h a day, over three generations. The average specific absorption 
      rate (SAR, in unit of W/kg) for dams was designed at three levels: high 
      (<0.24 W/kg), low (<0.08 W/kg), and 0 (sham exposure). Pregnant mothers 
      (4 rats/group) were exposed from gestational day (GD) 7 to weaning and then their 
      offspring (F1 generation, 4 males and 4 females/dam, respectively) were 
      continuously exposed until 6 weeks of age. The F1 females were mated with F1 
      males at 11 weeks old, and then starting from GD 7, they were exposed 
      continuously to the electromagnetic field (EMF; one half of the F1 offspring was 
      used for mating, that is, two of each sex per dam and 8 males and 
      8 females/group, except for all offspring for the functional development tests). 
      This protocol was repeated in the same manner on pregnant F2 females and F3 pups; 
      the latter were killed at 10 weeks of age. No abnormalities were observed in the 
      mother rats (F0 , F1 , and F2 ) and in the offspring (F1 , F2 , and F3 ) in any 
      biological parameters, including neurobehavioral function. Thus, it was concluded 
      that under the experimental conditions applied, multigenerational whole body 
      exposure to 2.14 GHz W-CDMA signals for 20 h/day did not cause any adverse 
      effects on the F1 , F2 , and F3 offspring.
CI  - (c) 2014 Wiley Periodicals, Inc.
FAU - Shirai, Tomoyuki
AU  - Shirai T
AD  - Department of Experimental Pathology and Tumor Biology, Nagoya City University 
      Graduate School of Medical Sciences, Nagoya, Japan.
FAU - Imai, Norio
AU  - Imai N
FAU - Wang, Jianqing
AU  - Wang J
FAU - Takahashi, Satoru
AU  - Takahashi S
FAU - Kawabe, Mayumi
AU  - Kawabe M
FAU - Wake, Kanako
AU  - Wake K
FAU - Kawai, Hiroki
AU  - Kawai H
FAU - Watanabe, So-Ichi
AU  - Watanabe S
FAU - Furukawa, Fumio
AU  - Furukawa F
FAU - Fujiwara, Osamu
AU  - Fujiwara O
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140904
PL  - United States
TA  - Bioelectromagnetics
JT  - Bioelectromagnetics
JID - 8008281
SB  - IM
MH  - Animals
MH  - Body Weight/radiation effects
MH  - Brain/anatomy & histology/physiology/*radiation effects
MH  - *Cell Phone
MH  - *Electromagnetic Fields
MH  - Exploratory Behavior/radiation effects
MH  - Female
MH  - Male
MH  - Maternal Exposure
MH  - Maze Learning/radiation effects
MH  - Motor Activity/radiation effects
MH  - Organ Size
MH  - Paternal Exposure
MH  - Radiation Genetics
MH  - Radiometry
MH  - Rats, Sprague-Dawley
MH  - Reproduction/radiation effects
OTO - NOTNLM
OT  - brain function
OT  - electromagnetic field
OT  - multigeneration
OT  - rat
OT  - whole-body exposure
EDAT- 2014/09/10 06:00
MHDA- 2015/06/13 06:00
CRDT- 2014/09/09 06:00
PHST- 2013/07/24 00:00 [received]
PHST- 2014/06/26 00:00 [accepted]
PHST- 2014/09/09 06:00 [entrez]
PHST- 2014/09/10 06:00 [pubmed]
PHST- 2015/06/13 06:00 [medline]
AID - 10.1002/bem.21871 [doi]
PST - ppublish
SO  - Bioelectromagnetics. 2014 Oct;35(7):497-511. doi: 10.1002/bem.21871. Epub 2014 
      Sep 4.