PMID- 25196819
OWN - NLM
STAT- MEDLINE
DCOM- 20151215
LR  - 20211021
IS  - 1552-4965 (Electronic)
IS  - 1549-3296 (Linking)
VI  - 103
IP  - 5
DP  - 2015 May
TI  - Novel bioresorbable stent coating for drug release in congenital heart disease 
      applications.
PG  - 1761-70
LID - 10.1002/jbm.a.35313 [doi]
AB  - A novel double opposed helical poly-l-lactic acid (PLLA) bioresorbable stent has 
      been designed for use in pediatrics. The aim was to test the PLLA stent 
      biocompatibility. The PLLA stent was immersed into whole pig's blood in a closed 
      loop circuit then fibrin and platelet association was assessed via enzyme-linked 
      immunosorbent assay. D-Dimer was valued at 0.2 +/- 0.002 ng/mL and P-selectin 
      0.43 +/- 00.01 ng/mL indicating limited association of fibrin and platelets on the 
      stent. To improve biocompatibility by targeting inflammatory cells, dexamethasone 
      was incorporated on PLLA fibers with two coating methods. Both coatings were 
      poly(l-lactide-co-glycolide) acid (PLGA) but one was made porous with sucrose 
      while the other remained nonporous. There was no change in mechanical properties 
      of the fiber with either coating of PLGA polymer. The total amount of 
      dexamethasone released was then determined for each coating. The cumulative drug 
      release for the porous fiber was significantly higher ( approximately 100%) over 8 weeks than 
      the nonporous fiber (40%). Surface examination of the fiber with scanning 
      electron microscopy showed more surface microfracturing in coatings that contain 
      pores. The biocompatibility of this novel stent was demonstrated. Mechanical 
      properties of the fiber were not altered by coating with PLGA polymer. 
      Anti-inflammatory drug release was optimized using a porous PLGA polymer.
CI  - (c) 2014 Wiley Periodicals, Inc.
FAU - Goodfriend, Amy C
AU  - Goodfriend AC
AD  - Department of Pediatric Cardiovascular and Thoracic Surgery, University of Texas 
      Southwestern Medical Center, Dallas, Texas, 75390.
FAU - Welch, Tre R
AU  - Welch TR
FAU - Barker, Greg
AU  - Barker G
FAU - Ginther, Richard Jr
AU  - Ginther R Jr
FAU - Riegel, Matthew S
AU  - Riegel MS
FAU - Reddy, Surendranath Veeram
AU  - Reddy SV
FAU - Wang, Jian
AU  - Wang J
FAU - Nugent, Alan
AU  - Nugent A
FAU - Forbess, Joseph
AU  - Forbess J
LA  - eng
GR  - S10 OD020103/OD/NIH HHS/United States
PT  - Journal Article
DEP - 20140916
PL  - United States
TA  - J Biomed Mater Res A
JT  - Journal of biomedical materials research. Part A
JID - 101234237
RN  - 0 (Coated Materials, Biocompatible)
RN  - 0 (Fibrin Fibrinogen Degradation Products)
RN  - 0 (P-Selectin)
RN  - 0 (fibrin fragment D)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 26009-03-0 (Polyglycolic Acid)
RN  - 33X04XA5AT (Lactic Acid)
RN  - 7S5I7G3JQL (Dexamethasone)
SB  - IM
MH  - *Absorbable Implants
MH  - Animals
MH  - Coated Materials, Biocompatible/*chemistry
MH  - Dexamethasone/pharmacology
MH  - *Drug Liberation
MH  - *Drug-Eluting Stents
MH  - Fibrin Fibrinogen Degradation Products/metabolism
MH  - Heart Defects, Congenital/*drug therapy
MH  - Lactic Acid/chemistry
MH  - Materials Testing
MH  - P-Selectin/metabolism
MH  - Polyglycolic Acid/chemistry
MH  - Polylactic Acid-Polyglycolic Acid Copolymer
MH  - Porosity
MH  - Spectroscopy, Fourier Transform Infrared
MH  - Stress, Mechanical
MH  - Sus scrofa
OTO - NOTNLM
OT  - PLLA stent
OT  - bioresorbable polymer
OT  - dexamethasone
OT  - hemocompatability
OT  - pediatrics
EDAT- 2014/09/10 06:00
MHDA- 2015/12/17 06:00
CRDT- 2014/09/09 06:00
PHST- 2014/03/11 00:00 [received]
PHST- 2014/05/06 00:00 [revised]
PHST- 2014/08/14 00:00 [accepted]
PHST- 2014/09/09 06:00 [entrez]
PHST- 2014/09/10 06:00 [pubmed]
PHST- 2015/12/17 06:00 [medline]
AID - 10.1002/jbm.a.35313 [doi]
PST - ppublish
SO  - J Biomed Mater Res A. 2015 May;103(5):1761-70. doi: 10.1002/jbm.a.35313. Epub 
      2014 Sep 16.