PMID- 25196858
OWN - NLM
STAT- MEDLINE
DCOM- 20170612
LR  - 20190320
IS  - 1756-185X (Electronic)
IS  - 1756-1841 (Linking)
VI  - 19
IP  - 7
DP  - 2016 Jul
TI  - Serum levels of visfatin, resistin and adiponectin in patients with psoriatic 
      arthritis and associations with disease severity.
PG  - 672-7
LID - 10.1111/1756-185X.12444 [doi]
AB  - AIM: Psoriatic arthritis (PsA) is an inflammatory form of arthritis typically 
      associated with psoriasis and/or psoriatic nail disease. Adipocytokines were once 
      thought to influence development of (only) insulin resistance and diabetes 
      mellitus. However, it is now clear that adipocytokines play important roles in 
      development of the inflammation associated with either autoimmune or 
      auto-inflammatory disorders. In the present study, we measured changes in the 
      serum levels of adiponectin, resistin and visfatin, and the associations of such 
      changes with the extent of disease activity and insulin resistance in PsA 
      patients. MATERIAL AND METHODS: A total of 67 subjects (28 with PsA and 39 
      healthy controls) without hypertension or diabetes mellitus were enrolled. 
      Adiponectin, resistin and visfatin levels, and the extent of insulin resistance 
      (assayed using the homeostasis model [HOMA-IR]), were measured in all subjects. 
      Assessment of PsA disease activity was done with the Disease Activity Index for 
      Psoriatic Arthritis (DAPSA). RESULTS: Psoriatic arthritis patients had 
      considerably higher serum levels of adiponectin, resistin and visfatin than did 
      healthy controls (all P < 0.05). In the logistic regression analysis, the 
      following variables may contribute to complex pathogenesis of PsA: adiponectin 
      (P = 0.001, OR = 3.1, 95% CI = 1.6-6.0), resistin (P = 006, OR = 1.8, 95% 
      CI = 1.2-2.9) and visfatin (P = 0.031, OR = 3.9, 95% CI = 1.1-13.9). In contrast, 
      we have not detected any correlation between DAPSA and adipocytokine serum levels 
      (P > 0.05). CONCLUSION: There is no correlation between adipocytokines and 
      disease activity. Although serum adiponectin, resistin and visfatin levels are 
      higher in patients with PsA, pathophysiological significance of the result has to 
      be evaluated with more extensive studies.
CI  - (c) 2014 The Authors. International Journal of Rheumatic Diseases published by Asia 
      Pacific League of Associations for Rheumatology and Wiley Publishing Asia Pty 
      Ltd.
FAU - Dikbas, Oguz
AU  - Dikbas O
AD  - Department of Endocrinology and Metabolism, School of Medicine, Abant Izzet 
      Baysal University, Bolu, Turkey.
FAU - Tosun, Mehmet
AU  - Tosun M
AD  - Department of Biochemistry, School of Medicine, Abant Izzet Baysal University, 
      Bolu, Turkey.
FAU - Bes, Cemal
AU  - Bes C
AD  - Department of Rheumatology, School of Medicine, Abant Izzet Baysal University, 
      Bolu, Turkey.
FAU - Tonuk, Sukru Burak
AU  - Tonuk SB
AD  - Department of Physical Therapy and Rehabilitation, School of Medicine, Abant 
      Izzet Baysal University, Bolu, Turkey.
FAU - Aksehirli, Ozge Yilmaz
AU  - Aksehirli OY
AD  - Department of Biostatistics, School of Medicine, Duzce University, Duzce, Turkey.
FAU - Soy, Mehmet
AU  - Soy M
AD  - Department of Rheumatology, School of Medicine, Abant Izzet Baysal University, 
      Bolu, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20140908
PL  - England
TA  - Int J Rheum Dis
JT  - International journal of rheumatic diseases
JID - 101474930
RN  - 0 (ADIPOQ protein, human)
RN  - 0 (Adiponectin)
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Cytokines)
RN  - 0 (Insulin)
RN  - 0 (RETN protein, human)
RN  - 0 (Resistin)
RN  - EC 2.4.2.12 (Nicotinamide Phosphoribosyltransferase)
RN  - EC 2.4.2.12 (nicotinamide phosphoribosyltransferase, human)
SB  - IM
MH  - Adiponectin/*blood
MH  - Adult
MH  - Arthritis, Psoriatic/*blood/diagnosis/physiopathology
MH  - Biomarkers/blood
MH  - Blood Glucose/analysis
MH  - Case-Control Studies
MH  - Chi-Square Distribution
MH  - Cytokines/*blood
MH  - Female
MH  - Humans
MH  - Insulin/blood
MH  - Insulin Resistance
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Nicotinamide Phosphoribosyltransferase/*blood
MH  - Odds Ratio
MH  - Resistin/*blood
MH  - Severity of Illness Index
MH  - Up-Regulation
OTO - NOTNLM
OT  - adiponectin
OT  - insulin resistance
OT  - psoriatic arthritis
OT  - resistin
OT  - visfatin
EDAT- 2014/09/10 06:00
MHDA- 2019/03/21 06:00
CRDT- 2014/09/09 06:00
PHST- 2014/09/09 06:00 [entrez]
PHST- 2014/09/10 06:00 [pubmed]
PHST- 2019/03/21 06:00 [medline]
AID - 10.1111/1756-185X.12444 [doi]
PST - ppublish
SO  - Int J Rheum Dis. 2016 Jul;19(7):672-7. doi: 10.1111/1756-185X.12444. Epub 2014 
      Sep 8.