PMID- 25196947
OWN - NLM
STAT- MEDLINE
DCOM- 20160502
LR  - 20201219
IS  - 1744-8395 (Electronic)
IS  - 1476-0584 (Linking)
VI  - 14
IP  - 2
DP  - 2015 Feb
TI  - mRNA-based dendritic cell vaccines.
PG  - 161-76
LID - 10.1586/14760584.2014.957684 [doi]
AB  - Cancer immunotherapy has been proposed as a powerful treatment modality. Active 
      immunotherapy aspires to stimulate the patient's immune system, particularly T 
      cells. These cells can recognize and kill cancer cells and can form an 
      immunological memory. Dendritic cells (DCs) are the professional 
      antigen-presenting cells of our immune system. They take up and process antigens 
      to present them to T cells. Consequently, DCs have been investigated as a means 
      to stimulate cancer-specific T-cell responses. An efficient strategy to program 
      DCs is the use of mRNA, a well-defined and safe molecule that can be easily 
      generated at high purity. Importantly, vaccines consisting of mRNA-modified DCs 
      showed promising results in clinical trials. Therefore, we will introduce cancer 
      immunotherapy and DCs and give a detailed overview on the application of mRNA to 
      generate cancer-fighting DC vaccines.
FAU - Benteyn, Daphne
AU  - Benteyn D
AD  - Laboratory of Molecular and Cellular Therapy, Department of Biomedical Sciences, 
      Vrije Universiteit Brussel, Laarbeeklaan 103/E, 1090 Jette, Belgium.
FAU - Heirman, Carlo
AU  - Heirman C
FAU - Bonehill, Aude
AU  - Bonehill A
FAU - Thielemans, Kris
AU  - Thielemans K
FAU - Breckpot, Karine
AU  - Breckpot K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20140908
PL  - England
TA  - Expert Rev Vaccines
JT  - Expert review of vaccines
JID - 101155475
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (Cancer Vaccines)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Antigen Presentation
MH  - Antigens, Neoplasm/*immunology
MH  - Cancer Vaccines/*immunology
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - Immunologic Memory
MH  - *Immunotherapy, Active
MH  - Neoplasms/*immunology/therapy
MH  - RNA, Messenger/*immunology
MH  - T-Lymphocytes/immunology
OTO - NOTNLM
OT  - cancer
OT  - cytotoxic T cell
OT  - dendritic cell
OT  - mRNA
OT  - tumor antigen
EDAT- 2014/09/10 06:00
MHDA- 2016/05/03 06:00
CRDT- 2014/09/09 06:00
PHST- 2014/09/09 06:00 [entrez]
PHST- 2014/09/10 06:00 [pubmed]
PHST- 2016/05/03 06:00 [medline]
AID - 10.1586/14760584.2014.957684 [doi]
PST - ppublish
SO  - Expert Rev Vaccines. 2015 Feb;14(2):161-76. doi: 10.1586/14760584.2014.957684. 
      Epub 2014 Sep 8.