PMID- 25197914
OWN - NLM
STAT- MEDLINE
DCOM- 20150616
LR  - 20140909
IS  - 1945-8932 (Electronic)
IS  - 1945-8932 (Linking)
VI  - 28
IP  - 4
DP  - 2014 Jul-Aug
TI  - Elevated total serum IgE in nonatopic patients with aspirin-exacerbated 
      respiratory disease.
PG  - 287-9
LID - 10.2500/ajra.2014.28.4054 [doi]
AB  - BACKGROUND: Aspirin-exacerbated respiratory disease (AERD), also known as 
      Samter's triad, is characterized by asthma, recurrent nasal polyps, and by 
      allergic-like reactions to aspirin and other nonsteroidal anti-inflammatory 
      drugs, although it is not a true immunoglobulin E (IgE)-mediated allergy. Atopy, 
      although common in patients with AERD, is not a characteristic of the disease. 
      Recently, we have observed a subgroup of patients with AERD who have no history 
      of atopy but have abnormally elevated total serum IgE, a phenomenon that has been 
      observed in patients with asthma but has not been further explored. We sought to 
      explore this phenomenon of elevated total serum IgE in the absence of atopy in a 
      subset of patients with AERD. METHODS: Patients were diagnosed with AERD with an 
      oral aspirin challenge at the Brigham and Women's Hospital Allergy and Clinics. 
      Atopy was defined as a positive test result to at least one of the common 
      aeroallergens. Elevated total serum IgE was defined as IgE of >100 IU/mL. 
      RESULTS: We present six patients with AERD and elevated total serum IgE in the 
      absence of any clear atopy. Total serum IgE in these patients ranged from 110 to 
      1760 IU/mL. Mean blood eosinophil levels for these patients were not 
      significantly different from those of the entire cohort of patients with AERD 
      included in the study. CONCLUSION: In a subset of patients with AERD, we observed 
      elevated total serum IgE even when atopy was not present. To better understand 
      the disease, the cause and clinical relevance of this phenomenon deserves further 
      exploration.
FAU - Johns, Christina B
AU  - Johns CB
AD  - Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, 
      Boston, Massachusetts, USA.
FAU - Laidlaw, Tanya M
AU  - Laidlaw TM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Rhinol Allergy
JT  - American journal of rhinology & allergy
JID - 101490775
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Asthma, Aspirin-Induced/*immunology
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Male
MH  - Middle Aged
EDAT- 2014/09/10 06:00
MHDA- 2015/06/17 06:00
CRDT- 2014/09/09 06:00
PHST- 2014/09/09 06:00 [entrez]
PHST- 2014/09/10 06:00 [pubmed]
PHST- 2015/06/17 06:00 [medline]
AID - 10.2500/ajra.2014.28.4054 [doi]
PST - ppublish
SO  - Am J Rhinol Allergy. 2014 Jul-Aug;28(4):287-9. doi: 10.2500/ajra.2014.28.4054.