PMID- 25199983
OWN - NLM
STAT- MEDLINE
DCOM- 20150731
LR  - 20171116
IS  - 1873-3360 (Electronic)
IS  - 0306-4530 (Linking)
VI  - 50
DP  - 2014 Dec
TI  - Neurophysiological correlates of metabolic syndrome and cognitive impairment in 
      schizophrenia: a structural equation modeling approach.
PG  - 95-105
LID - S0306-4530(14)00295-9 [pii]
LID - 10.1016/j.psyneuen.2014.07.019 [doi]
AB  - OBJECTIVE: We aimed to investigate the brain functional substrate underlying 
      relationships between metabolic syndrome (MetS) and cognitive impairment in 
      schizophrenia. METHODS: In this cross-sectional study, we collected 
      socio-demographic, clinical, anthropometric, blood, and cognition data and 
      performed brain 99mTc-ECD-SPECT imaging of cerebral blood flow in patients with 
      schizophrenia. Patients were grouped according to the absence or presence of 
      MetS. Whole-brain perfusion SPECTs were compared at voxel level between these two 
      groups, and voxel-wise interregional correlation was performed to compare 
      functional connectivity (voxel level significance of p<0.005, uncorrected; p<0.05 
      for the cluster, uncorrected; using SPM8). A structural equation model (SEM) was 
      applied to examine the relationships between brain perfusion, connectivity 
      between brain areas, and cognition. RESULTS: Of the 55 patients, 17 had MetS. 
      They performed significantly worse than patients without MetS on tests of 
      executive functions (processing speed p=0.005 for TMT-A; and reactive flexibility 
      p=0.014 for TMT-B), attention (D2 attention task p=0.007), and memory (California 
      Verbal Learning Test p=0.039). In comparison to patients without MetS, those with 
      MetS exhibited significant hypoperfusion within the left orbital prefrontal 
      cortex and greater functional connectivity from this left frontal cluster within 
      the left insula and middle/superior frontal gyrus. SEM confirmed the effect on 
      executive functions of brain hypoperfusion and of increased connectivity, 
      suggesting possible compensatory networks in patients with MetS. CONCLUSION: Our 
      study identifies the brain functional impact of MetS on cognition, with orbital 
      prefrontal impairment and possible compensatory networks.
CI  - Copyright (c) 2014 Elsevier Ltd. All rights reserved.
FAU - Boyer, Laurent
AU  - Boyer L
AD  - Aix-Marseille Univ, EA 3279 - Public Health, Chronic Diseases and Quality of Life 
      - Research Unit, 13005 Marseille, France. Electronic address: 
      laurent.boyer@ap-hm.fr.
FAU - Testart, Julien
AU  - Testart J
AD  - Department of Psychiatry, Sainte-Marguerite University Hospital, 13009 Marseille, 
      France.
FAU - Michel, Pierre
AU  - Michel P
AD  - Aix-Marseille Univ, EA 3279 - Public Health, Chronic Diseases and Quality of Life 
      - Research Unit, 13005 Marseille, France.
FAU - Richieri, Raphaelle
AU  - Richieri R
AD  - Department of Psychiatry, Sainte-Marguerite University Hospital, 13009 Marseille, 
      France.
FAU - Faget-Agius, Catherine
AU  - Faget-Agius C
AD  - Department of Psychiatry, Sainte-Marguerite University Hospital, 13009 Marseille, 
      France.
FAU - Vanoye, Violette
AU  - Vanoye V
AD  - Department of Psychiatry, Sainte-Marguerite University Hospital, 13009 Marseille, 
      France.
FAU - Auquier, Pascal
AU  - Auquier P
AD  - Aix-Marseille Univ, EA 3279 - Public Health, Chronic Diseases and Quality of Life 
      - Research Unit, 13005 Marseille, France.
FAU - Lancon, Christophe
AU  - Lancon C
AD  - Aix-Marseille Univ, EA 3279 - Public Health, Chronic Diseases and Quality of Life 
      - Research Unit, 13005 Marseille, France; Department of Psychiatry, 
      Sainte-Marguerite University Hospital, 13009 Marseille, France.
FAU - Guedj, Eric
AU  - Guedj E
AD  - APHM, Hopital de la Timone, Service Central de Biophysique et Medecine Nucleaire, 
      13005 Marseille, France; Aix-Marseille Univ, CERIMED 13005, Marseille, France; 
      Aix-Marseille Univ, INT, 13005 Marseille, France.
LA  - eng
PT  - Journal Article
DEP - 20140810
PL  - England
TA  - Psychoneuroendocrinology
JT  - Psychoneuroendocrinology
JID - 7612148
SB  - IM
MH  - Adult
MH  - Brain/diagnostic imaging/*physiopathology
MH  - Cerebrovascular Circulation/physiology
MH  - Cognition Disorders/complications/diagnostic imaging/*physiopathology
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Metabolic Syndrome/complications/diagnostic imaging/*physiopathology
MH  - Middle Aged
MH  - *Models, Theoretical
MH  - Neuropsychological Tests
MH  - Radionuclide Imaging
MH  - Schizophrenia/complications/diagnostic imaging/*physiopathology
OTO - NOTNLM
OT  - Cerebral blood flow
OT  - Cognition
OT  - Metabolic syndrome
OT  - SPM
OT  - Schizophrenia
OT  - Single-photon emission computed tomography (SPECT)
OT  - Structural equation modeling
EDAT- 2014/09/10 06:00
MHDA- 2015/08/01 06:00
CRDT- 2014/09/10 06:00
PHST- 2014/03/18 00:00 [received]
PHST- 2014/07/18 00:00 [revised]
PHST- 2014/07/18 00:00 [accepted]
PHST- 2014/09/10 06:00 [entrez]
PHST- 2014/09/10 06:00 [pubmed]
PHST- 2015/08/01 06:00 [medline]
AID - S0306-4530(14)00295-9 [pii]
AID - 10.1016/j.psyneuen.2014.07.019 [doi]
PST - ppublish
SO  - Psychoneuroendocrinology. 2014 Dec;50:95-105. doi: 
      10.1016/j.psyneuen.2014.07.019. Epub 2014 Aug 10.