PMID- 25200156
OWN - NLM
STAT- MEDLINE
DCOM- 20150212
LR  - 20240109
IS  - 1007-8738 (Print)
IS  - 1007-8738 (Linking)
VI  - 30
IP  - 9
DP  - 2014 Sep
TI  - [Ginger extracts improve renal injury of high fructose-fed SD rats by inhibiting 
      the expression of proinflammatory cytokines].
PG  - 929-32
AB  - OBJECTIVE: To investigated the effects of ginger extracts on renal injury in high 
      fructose-fed SD rats and the possible underlying mechanism. METHODS: Twenty rats 
      were randomly divided into control group, fructose group, 20 and 50 mg/kg ginger 
      extract groups, 5 rats in each group. The general situation and histopathological 
      changes in the kidney of rats were observed. The expressions of monocyte 
      chemokine protein 1 (MCP-1), tumor necrosis factor alpha (TNF-alpha) and interleukin 6 
      (IL-6) mRNA were detected by real-time quantitative PCR (qRT-PCR); the levels of 
      MCP-1, TNF-alpha and IL-6 in supernatant of renal tissue homogenates were assessed by 
      ELISA. RESULTS: Compared to the control group, the kidney mass and the ratio of 
      kidney-to-body mass significantly decreased in fructose group, accompanied by 
      renal tubular injury. Ginger extracts at 50 mg/kg evidently improved renal 
      tubular injury, suppressed the expressions of renal MCP-1, TNF-alpha and IL-6 mRNA 
      (P<0.05) and decreased the levels of MCP-1 (P<0.05), TNF-alpha (P<0.01), IL-6 
      (P<0.05) in kidney tissue homogenates. CONCLUSION: The supplement of ginger 
      extracts can improve fructose-induced renal injury, which may be associated with 
      the suppression on the expression of proinflammatory cytokines.
FAU - Yang, Ming
AU  - Yang M
AD  - Laboratory of Stem Cell and Tissue Engineering, Department of Histology and 
      Embryology, Chongqing Medical University, Chongqing 400016, China.
FAU - Jiang, Rong
AU  - Jiang R
AD  - Laboratory of Stem Cell and Tissue Engineering, Department of Histology and 
      Embryology, Chongqing Medical University, Chongqing 400016, China.
FAU - Lin, Xuemei
AU  - Lin X
AD  - Laboratory of Stem Cell and Tissue Engineering, Department of Histology and 
      Embryology, Chongqing Medical University, Chongqing 400016, China.
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
JT  - Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular 
      immunology
JID - 101139110
RN  - 0 (Ccl2 protein, rat)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Cytokines)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Interleukin-6)
RN  - 0 (Plant Extracts)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 30237-26-4 (Fructose)
SB  - IM
MH  - Animals
MH  - Chemokine CCL2/genetics/metabolism
MH  - Cytokines/*genetics/metabolism
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Fructose
MH  - Gene Expression Regulation/*drug effects
MH  - Zingiber officinale/*chemistry
MH  - Inflammation Mediators/metabolism
MH  - Interleukin-6/genetics/metabolism
MH  - Kidney/drug effects/metabolism/pathology
MH  - Kidney Diseases/chemically induced/genetics/*prevention & control
MH  - Male
MH  - Plant Extracts/*pharmacology
MH  - Rats, Sprague-Dawley
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Tumor Necrosis Factor-alpha/genetics/metabolism
EDAT- 2014/09/10 06:00
MHDA- 2015/02/13 06:00
CRDT- 2014/09/10 06:00
PHST- 2014/09/10 06:00 [entrez]
PHST- 2014/09/10 06:00 [pubmed]
PHST- 2015/02/13 06:00 [medline]
PST - ppublish
SO  - Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2014 Sep;30(9):929-32.