PMID- 25200813 OWN - NLM STAT- MEDLINE DCOM- 20160412 LR - 20221207 IS - 1873-460X (Electronic) IS - 1056-8727 (Linking) VI - 29 IP - 1 DP - 2015 Jan-Feb TI - High body fat and low muscle mass are associated with increased arterial stiffness in Asian Indians in North India. PG - 38-43 LID - S1056-8727(14)00232-3 [pii] LID - 10.1016/j.jdiacomp.2014.08.001 [doi] AB - AIM: To investigate the associations of high body fat and low muscle mass with arterial stiffness in Asian Indians with type 2 diabetes mellitus (T2DM) in North India. METHODS: In this cross sectional study, subjects with T2DM (males n=110, females n=58, mean age: 53.8+/-10.0years) were recruited. Anthropometry and body composition analysis were performed and measures of glycemia, lipids and PWV were analyzed. RESULTS: Significant positive correlation was observed between PWV and body fat (p<0.05), left leg fat (p<0.05), and right leg fat (p<0.01) percentages only in females. In males, significant negative correlation was observed between PWV and truncal fat free mass (p<0.05) and fat free mass in right arm (p=0.05) and left arm (p<0.05). In both males and females, significant negative correlation was observed between PWV and fat free mass in left leg (p<0.01) and for right leg fat free mass only in females. CONCLUSION: Excess adiposity and low fat free mass are associated with arterial stiffening in Asian Indians with T2DM in North India, with significant gender differences. CI - Copyright (c) 2015 Elsevier Inc. All rights reserved. FAU - Anoop, Shajith AU - Anoop S AD - Center of Nutrition & Metabolic Research (C-NET), National Diabetes, Obesity and Cholesterol Foundation (N-DOC), SDA, New Delhi, India; Diabetes Foundation (India), SDA, New Delhi. FAU - Misra, Anoop AU - Misra A AD - Center of Nutrition & Metabolic Research (C-NET), National Diabetes, Obesity and Cholesterol Foundation (N-DOC), SDA, New Delhi, India; Diabetes Foundation (India), SDA, New Delhi; Fortis C-DOC Centre of Excellence for Diabetes, Metabolic Diseases and Endocrinology, Chirag Enclave, Nehru place, New Delhi; Fortis Flt. Lt. Rajan Dhall Hospital, Vasant Kunj, New Delhi, India. Electronic address: anoopmisra@metabolicresearchindia.com. FAU - Bhardwaj, Swati AU - Bhardwaj S AD - Center of Nutrition & Metabolic Research (C-NET), National Diabetes, Obesity and Cholesterol Foundation (N-DOC), SDA, New Delhi, India; Diabetes Foundation (India), SDA, New Delhi. FAU - Gulati, Seema AU - Gulati S AD - Center of Nutrition & Metabolic Research (C-NET), National Diabetes, Obesity and Cholesterol Foundation (N-DOC), SDA, New Delhi, India; Diabetes Foundation (India), SDA, New Delhi. LA - eng PT - Journal Article DEP - 20140808 PL - United States TA - J Diabetes Complications JT - Journal of diabetes and its complications JID - 9204583 SB - IM MH - Adipose Tissue MH - Asian People/statistics & numerical data MH - *Body Mass Index MH - Cross-Sectional Studies MH - Diabetes Mellitus, Type 2/diagnosis/*ethnology MH - Female MH - Humans MH - Incidence MH - India/epidemiology MH - Male MH - Middle Aged MH - Muscle, Skeletal/*physiology MH - Muscular Atrophy/diagnosis/epidemiology MH - Obesity/diagnosis/*ethnology MH - Organ Size MH - Retrospective Studies MH - Risk Assessment MH - Severity of Illness Index MH - Sex Distribution MH - Vascular Stiffness/*physiology OTO - NOTNLM OT - Arterial stiffness OT - Asian Indians OT - High body fat OT - Muscle mass OT - Type 2 diabetes EDAT- 2014/09/10 06:00 MHDA- 2016/04/14 06:00 CRDT- 2014/09/10 06:00 PHST- 2014/06/10 00:00 [received] PHST- 2014/08/03 00:00 [revised] PHST- 2014/08/03 00:00 [accepted] PHST- 2014/09/10 06:00 [entrez] PHST- 2014/09/10 06:00 [pubmed] PHST- 2016/04/14 06:00 [medline] AID - S1056-8727(14)00232-3 [pii] AID - 10.1016/j.jdiacomp.2014.08.001 [doi] PST - ppublish SO - J Diabetes Complications. 2015 Jan-Feb;29(1):38-43. doi: 10.1016/j.jdiacomp.2014.08.001. Epub 2014 Aug 8.