PMID- 25200861
OWN - NLM
STAT- MEDLINE
DCOM- 20151215
LR  - 20220311
IS  - 2210-741X (Electronic)
IS  - 2210-7401 (Linking)
VI  - 39
IP  - 1
DP  - 2015 Feb
TI  - Estrogen receptor 1 (ESR1) genetic variations in cancer risk: a systematic review 
      and meta-analysis.
PG  - 127-35
LID - S2210-7401(14)00179-X [pii]
LID - 10.1016/j.clinre.2014.07.016 [doi]
AB  - BACKGROUND: Emerging published data on the association between single nucleotide 
      polymorphisms (SNPs) in the estrogen receptor 1 (ESR1) gene and cancer 
      susceptibility are inconsistent. This review and meta-analysis is performed to 
      derive a more precise evaluation of this relationship. METHODS: The literature 
      search of PubMed, Embase, Web of Science and CNKI databases was conducted from 
      their inception through June 2014. Crude odds ratios (ORs) with 95% confidence 
      intervals (CIs) were calculated to assess the association. RESULTS: Twenty-two 
      literatures were enrolled in this meta-analysis. The results indicated that ESR1 
      rs1801132 (C>G) was associated with cancer risk in Caucasian populations. 
      However, the results of stratified analysis by cancer type and source of controls 
      indicated that no significant association was found. Furthermore, rs2077647 (A>G) 
      was only associated with an increased risk of hepatocellular carcinoma, but was 
      an adverse effect on cancer risk in Caucasian populations. CONCLUSIONS: This 
      present meta-analysis indicated that rs1801132 (C>G) and rs2077647 (A>G) may be 
      protective factors in Caucasian populations. Meanwhile, rs2077647 (A>G) may be 
      closely related with hepatocellular carcinoma.
CI  - Copyright (c) 2014 Elsevier Masson SAS. All rights reserved.
FAU - Sun, Huiling
AU  - Sun H
AD  - Department of Life Sciences, Nanjing Normal University, Nanjing 210046, Jiangsu, 
      China.
FAU - Hou, Jinjun
AU  - Hou J
AD  - Clinical Laboratory, Mother and Child Health Care Hospital of Qixia District, 
      Nanjing, Nanjing 210028, Jiangsu, China; Clinical Laboratory, The North Branch of 
      Nanjing Mother and Child Health Care Hospital, Nanjing 210004, Jiangsu, China. 
      Electronic address: jinjun_hou@163.com.
FAU - Shi, Wenbin
AU  - Shi W
AD  - Clinical Laboratory, Nanjing Traditional Chinese Medical Hospital, Nanjing 
      210001, Jiangsu, China.
FAU - Zhang, Lei
AU  - Zhang L
AD  - Department of Orthopaedics, Lanxi People's Hospital, Jinhua, 321100 Zhejiang, 
      China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20140915
PL  - France
TA  - Clin Res Hepatol Gastroenterol
JT  - Clinics and research in hepatology and gastroenterology
JID - 101553659
RN  - 0 (ESR1 protein, human)
RN  - 0 (Estrogen Receptor alpha)
SB  - IM
MH  - Carcinoma, Hepatocellular/epidemiology/*genetics
MH  - Estrogen Receptor alpha/*genetics
MH  - Genetic Variation
MH  - Humans
MH  - Liver Neoplasms/epidemiology/*genetics
MH  - Risk
EDAT- 2014/09/10 06:00
MHDA- 2015/12/17 06:00
CRDT- 2014/09/10 06:00
PHST- 2014/06/16 00:00 [received]
PHST- 2014/07/10 00:00 [revised]
PHST- 2014/07/23 00:00 [accepted]
PHST- 2014/09/10 06:00 [entrez]
PHST- 2014/09/10 06:00 [pubmed]
PHST- 2015/12/17 06:00 [medline]
AID - S2210-7401(14)00179-X [pii]
AID - 10.1016/j.clinre.2014.07.016 [doi]
PST - ppublish
SO  - Clin Res Hepatol Gastroenterol. 2015 Feb;39(1):127-35. doi: 
      10.1016/j.clinre.2014.07.016. Epub 2014 Sep 15.