PMID- 25202180
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140909
LR  - 20220409
IS  - 0915-5287 (Print)
IS  - 2187-5626 (Electronic)
IS  - 0915-5287 (Linking)
VI  - 26
IP  - 8
DP  - 2014 Aug
TI  - The Effects of 12 Weeks Regular Aerobic Exercise on Brain-derived Neurotrophic 
      Factor and Inflammatory Factors in Juvenile Obesity and Type 2 Diabetes Mellitus.
PG  - 1199-204
LID - 10.1589/jpts.26.1199 [doi]
AB  - [Purpose] The purpose of this study was to investigate the effects of 12 weeks 
      regular aerobic exercise on brain-derived neurotrophic factor (BDNF) and 
      inflammatory factors in juvenile obesity and type 2 diabetes mellitus (T2DM). 
      Obesity and T2DM, typically common among adults, have recently become more 
      prevalent in the Korean juvenile population, affecting not only their lipid 
      profiles and oxidant stress levels, but also their BDNF and inflammatory factor 
      levels. [Subjects] This study enrolled 26 juveniles (boys = 15, girls = 9) who 
      were assigned to a control group (CG, n = 11), obesity group (OG, n = 8), or T2DM 
      group (TG, n = 7). [Methods] The outcome of a 40-60-minute aerobic exercise 
      session that took place three times per week for 12 weeks at a maximum oxygen 
      intake (VO2max) of 50~60% was investigated. [Results] The exercise resulted in a 
      significant reduction in the resting serum BDNF and TrkB levels (baseline) among 
      juveniles in the OG and TG as compared to those in the CG. Additionally, the 12 
      weeks of regular aerobic exercise led to significant reductions in body weight, 
      body fat percentage, and body mass index in the OG and a significant increase of 
      VO2max in the OG and TG. However, no significant differences in serum NGF or 
      inflammatory factors were found among the three groups. There was a significant 
      increase in resting serum BDNF levels following the 12 weeks regular exercise 
      only in the OG. [Conclusion] While 12 weeks of regular aerobic exercise had a 
      positive effect on body composition, and increased BDNF levels of juveniles in 
      the OG, it did not affect the inflammatory factor levels and had no effect on the 
      TG.
FAU - Lee, Sung Soo
AU  - Lee SS
AD  - Department of Physical Education, College of Sports Science, Dong-A University, 
      Republic of Korea.
FAU - Yoo, Jae Ho
AU  - Yoo JH
AD  - Department of Pediatrics, College of Medicine, Dong-A University Medical Center, 
      Republic of Korea.
FAU - Kang, Sung
AU  - Kang S
AD  - Department of Aero Physical Education, Republic of Korea Airforce Academy, 
      Republic of Korea.
FAU - Woo, Jin Hee
AU  - Woo JH
AD  - Department of Physical Education, College of Sports Science, Dong-A University, 
      Republic of Korea.
FAU - Shin, Ki Ok
AU  - Shin KO
AD  - Department of Physical Education, College of Sports Science, Dong-A University, 
      Republic of Korea.
FAU - Kim, Kwi Beak
AU  - Kim KB
AD  - Department of Sport and Health Management, College of Sports Science, Young-san 
      University, Republic of Korea.
FAU - Cho, Su Youn
AU  - Cho SY
AD  - Department of Physical Education, Yon-sei University, Republic of Korea.
FAU - Roh, Hee Tae
AU  - Roh HT
AD  - Department of Physical Education, Yon-sei University, Republic of Korea.
FAU - Kim, Young Il
AU  - Kim YI
AD  - Department of Sport and Health Management, College of Sports Science, Young-san 
      University, Republic of Korea.
LA  - eng
PT  - Journal Article
DEP - 20140830
PL  - Japan
TA  - J Phys Ther Sci
JT  - Journal of physical therapy science
JID - 9105359
PMC - PMC4155219
OTO - NOTNLM
OT  - BDNF
OT  - Obesity
OT  - T2DM
EDAT- 2014/09/10 06:00
MHDA- 2014/09/10 06:01
PMCR- 2014/08/01
CRDT- 2014/09/10 06:00
PHST- 2014/01/10 00:00 [received]
PHST- 2014/02/16 00:00 [accepted]
PHST- 2014/09/10 06:00 [entrez]
PHST- 2014/09/10 06:00 [pubmed]
PHST- 2014/09/10 06:01 [medline]
PHST- 2014/08/01 00:00 [pmc-release]
AID - jpts-2013-606 [pii]
AID - 10.1589/jpts.26.1199 [doi]
PST - ppublish
SO  - J Phys Ther Sci. 2014 Aug;26(8):1199-204. doi: 10.1589/jpts.26.1199. Epub 2014 
      Aug 30.