PMID- 25202928
OWN - NLM
STAT- MEDLINE
DCOM- 20150610
LR  - 20141003
IS  - 1473-558X (Electronic)
IS  - 0959-4965 (Linking)
VI  - 25
IP  - 16
DP  - 2014 Nov 12
TI  - Neurotrophic effects of taurine on spiral ganglion neurons in vitro.
PG  - 1250-4
LID - 10.1097/WNR.0000000000000254 [doi]
AB  - Taurine is an ubiquitary expressed aminosulfonic acid known to play an important 
      role in the development and maintenance of the nervous system. It is distributed 
      in the inner ear, contributing toward the protection of hair cells against 
      aminoglycoside-induced or bilirubin-induced ototoxicity. Thus, the question 
      arises whether taurine also has an influence on the cellular integrity of the 
      auditory neurons. To test this hypothesis, isolated cells of the spiral ganglion 
      were cocultured with taurine or the neurotrophic factors brain derived 
      neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) as controls. The analysis 
      included cellular survival rate and neurite outgrowth. With application of 
      taurine, the survival of glial cells and neurons was stimulated in a similar 
      pattern, whereas BDNF and NT-3 only effected neuronal survival. Furthermore, 
      administration of taurine resulted in enhanced neurite outgrowth comparable with 
      the effect of the neurotrophic factors. These new insights on the neuromodulatory 
      effects of taurine on auditory neurons suggest the use of this aminosulfonic acid 
      to reduce the degeneration of auditory neurons in sensorineural hearing loss. 
      Consecutively, a new therapeutical approach for the therapy of hearing impairment 
      could be discussed.
FAU - Rak, Kristen
AU  - Rak K
AD  - aDepartment of Oto-Rhino-Laryngology, Plastic, Aesthetic and Reconstructive Head 
      and Neck Surgery, Comprehensive Hearing Center bInstitute for Clinical 
      Neurobiology, University of Wuerzburg cDepartment of Oto-Rhino-Laryngology, Head 
      and Neck Surgery 'Otto Korner', Rostock University Medical Center, Rostock, 
      Germany.
FAU - Volker, Johannes
AU  - Volker J
FAU - Jurgens, Lukas
AU  - Jurgens L
FAU - Scherzad, Agmal
AU  - Scherzad A
FAU - Schendzielorz, Philipp
AU  - Schendzielorz P
FAU - Radeloff, Andreas
AU  - Radeloff A
FAU - Jablonka, Sibylle
AU  - Jablonka S
FAU - Mlynski, Robert
AU  - Mlynski R
FAU - Hagen, Rudolf
AU  - Hagen R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Neuroreport
JT  - Neuroreport
JID - 9100935
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Neurotrophin 3)
RN  - 1EQV5MLY3D (Taurine)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/pharmacology
MH  - Cell Survival/drug effects
MH  - Cells, Cultured
MH  - Neurites/drug effects
MH  - Neuroglia/drug effects
MH  - Neurons/*drug effects
MH  - Neurotrophin 3/pharmacology
MH  - Rats, Sprague-Dawley
MH  - Spiral Ganglion/*drug effects
MH  - Taurine/*pharmacology
EDAT- 2014/09/10 06:00
MHDA- 2015/06/11 06:00
CRDT- 2014/09/10 06:00
PHST- 2014/09/10 06:00 [entrez]
PHST- 2014/09/10 06:00 [pubmed]
PHST- 2015/06/11 06:00 [medline]
AID - 10.1097/WNR.0000000000000254 [doi]
PST - ppublish
SO  - Neuroreport. 2014 Nov 12;25(16):1250-4. doi: 10.1097/WNR.0000000000000254.