PMID- 25203115
OWN - NLM
STAT- MEDLINE
DCOM- 20150609
LR  - 20191210
IS  - 1944-0057 (Electronic)
IS  - 1944-0057 (Linking)
VI  - 31
IP  - 10
DP  - 2014
TI  - Multi-commutated fluorometric optosensor for the determination of citrinin in 
      rice and red yeast rice supplements.
PG  - 1744-50
LID - 10.1080/19440049.2014.949874 [doi]
AB  - Citrinin is a toxic secondary metabolite first isolated from Penicillium 
      citrinum, although is also produced by other species of Penicillium and 
      Aspergillus. It has highly toxic, mutagenic, teratogenic and carcinogenic 
      properties and is often found in crops, vegetables and fruit. To our knowledge 
      there is no specific legislation on maximum levels permitted for citrinin, so no 
      official analytical method is currently available for its determination. Our 
      laboratory developed a fluorometric flow-through optosensor using Sephadex SPC-25 
      as solid support. Multi-commutated flow injection analysis was used for the 
      construction of the manifold and for handling solutions. In this way, we 
      minimised waste generation and human intervention, which are critical aspects 
      when dealing with highly toxic compounds such as citrinin. The optimum 
      excitation/emission wavelengths were set at 330/494 nm; the calibration curve was 
      linear in the concentration range 35-900 ng ml(-)(1). A detection limit of 10.5 ng 
      ml(-)(1) and relative standard deviations (RSDs) lower than 3% were obtained. The 
      developed optosensor was applied to the determination of citrinin in rice and 
      dietary supplements containing red yeast rice.
FAU - Jimenez-Lopez, J
AU  - Jimenez-Lopez J
AD  - a Department of Physical and Analytical Chemistry, Faculty of Experimental 
      Sciences , University of Jaen , Jaen , Spain.
FAU - Llorent-Martinez, E J
AU  - Llorent-Martinez EJ
FAU - Ortega-Barrales, P
AU  - Ortega-Barrales P
FAU - Ruiz-Medina, A
AU  - Ruiz-Medina A
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140909
PL  - England
TA  - Food Addit Contam Part A Chem Anal Control Expo Risk Assess
JT  - Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & 
      risk assessment
JID - 101485040
RN  - 0 (Carcinogens, Environmental)
RN  - 3S697X6SNZ (Citrinin)
SB  - IM
MH  - Analytic Sample Preparation Methods
MH  - Automation, Laboratory
MH  - Calibration
MH  - Carcinogens, Environmental/*analysis/isolation & purification
MH  - Citrinin/*analysis/isolation & purification
MH  - Dietary Supplements/*analysis/economics
MH  - Fermentation
MH  - Fluorometry
MH  - *Food Contamination
MH  - Food Handling
MH  - Food Inspection/*methods
MH  - Limit of Detection
MH  - Liquid-Liquid Extraction
MH  - Monascus/chemistry/metabolism
MH  - Oryza/*chemistry/economics/microbiology
MH  - Reproducibility of Results
MH  - Seeds/*chemistry/microbiology
MH  - Spain
OTO - NOTNLM
OT  - food
OT  - luminescence
OT  - multi-commutation
OT  - mycotoxin
OT  - rice
OT  - solid-phase spectroscopy
EDAT- 2014/09/10 06:00
MHDA- 2015/06/10 06:00
CRDT- 2014/09/10 06:00
PHST- 2014/09/10 06:00 [entrez]
PHST- 2014/09/10 06:00 [pubmed]
PHST- 2015/06/10 06:00 [medline]
AID - 10.1080/19440049.2014.949874 [doi]
PST - ppublish
SO  - Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2014;31(10):1744-50. 
      doi: 10.1080/19440049.2014.949874. Epub 2014 Sep 9.