PMID- 25204496
OWN - NLM
STAT- MEDLINE
DCOM- 20160517
LR  - 20240323
IS  - 1559-1182 (Electronic)
IS  - 0893-7648 (Print)
IS  - 0893-7648 (Linking)
VI  - 52
IP  - 1
DP  - 2015 Aug
TI  - Beta-Amyloid Precursor Protein (betaAPP) Processing in Alzheimer's Disease (AD) and 
      Age-Related Macular Degeneration (AMD).
PG  - 533-44
LID - 10.1007/s12035-014-8886-3 [doi]
AB  - Amyloid is a generic term for insoluble, often intensely hydrophobic, fibrous 
      protein aggregates that arise from inappropriately folded versions of 
      naturally-occurring polypeptides. The abnormal generation and accumulation of 
      amyloid, often referred to as amyloidogenesis, has been associated with the 
      immune and pro-inflammatory pathology of several progressive age-related diseases 
      of the human central nervous system (CNS) including Alzheimer's disease (AD) and 
      age-related macular degeneration (AMD). This 'research perspective' paper reviews 
      some of the research history, biophysics, molecular-genetics and environmental 
      factors concerning the contribution of amyloid beta (Abeta) peptides, derived from 
      beta-amyloid precursor protein (betaAPP), to AD and AMD that suggests an extensive 
      similarity in immune and inflammatory degenerative mechanisms between these two 
      CNS diseases.
FAU - Zhao, Yuhai
AU  - Zhao Y
AD  - LSU Neuroscience Center, Louisiana State University Health Sciences Center, 2020 
      Gravier Street, Suite 904, New Orleans, LA, 70112, USA.
FAU - Bhattacharjee, Surjyadipta
AU  - Bhattacharjee S
FAU - Jones, Brandon M
AU  - Jones BM
FAU - Hill, James M
AU  - Hill JM
FAU - Clement, Christian
AU  - Clement C
FAU - Sambamurti, Kumar
AU  - Sambamurti K
FAU - Dua, Prerna
AU  - Dua P
FAU - Lukiw, Walter J
AU  - Lukiw WJ
LA  - eng
GR  - R01 AG018031/AG/NIA NIH HHS/United States
GR  - R21 AG046200/AG/NIA NIH HHS/United States
GR  - NIA AG18031/AG/NIA NIH HHS/United States
GR  - P30-GM103340/GM/NIGMS NIH HHS/United States
GR  - NEI EY006311/EY/NEI NIH HHS/United States
GR  - P30 GM103340/GM/NIGMS NIH HHS/United States
GR  - R01 EY006311/EY/NEI NIH HHS/United States
GR  - NIA P50AG16573/AG/NIA NIH HHS/United States
GR  - NIA AG038834/AG/NIA NIH HHS/United States
GR  - P50 AG016573/AG/NIA NIH HHS/United States
GR  - NIH NIA AG046200/AG/NIA NIH HHS/United States
GR  - R01 AG038834/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20140910
PL  - United States
TA  - Mol Neurobiol
JT  - Molecular neurobiology
JID - 8900963
RN  - 0 (Amyloid beta-Peptides)
SB  - IM
MH  - Alzheimer Disease/*complications/genetics/*pathology
MH  - Amyloid beta-Peptides/*metabolism
MH  - Animals
MH  - Disease Models, Animal
MH  - Epigenesis, Genetic
MH  - Humans
MH  - Macular Degeneration/*complications/genetics/*pathology
MH  - *Protein Processing, Post-Translational
PMC - PMC4362880
MID - NIHMS627270
EDAT- 2014/09/11 06:00
MHDA- 2016/05/18 06:00
PMCR- 2016/08/01
CRDT- 2014/09/11 06:00
PHST- 2014/07/01 00:00 [received]
PHST- 2014/08/27 00:00 [accepted]
PHST- 2014/09/11 06:00 [entrez]
PHST- 2014/09/11 06:00 [pubmed]
PHST- 2016/05/18 06:00 [medline]
PHST- 2016/08/01 00:00 [pmc-release]
AID - 10.1007/s12035-014-8886-3 [pii]
AID - 10.1007/s12035-014-8886-3 [doi]
PST - ppublish
SO  - Mol Neurobiol. 2015 Aug;52(1):533-44. doi: 10.1007/s12035-014-8886-3. Epub 2014 
      Sep 10.