PMID- 25205514
OWN - NLM
STAT- MEDLINE
DCOM- 20150812
LR  - 20220317
IS  - 1538-7755 (Electronic)
IS  - 1055-9965 (Linking)
VI  - 23
IP  - 12
DP  - 2014 Dec
TI  - Genetic associations in classical hodgkin lymphoma: a systematic review and 
      insights into susceptibility mechanisms.
PG  - 2737-47
LID - 10.1158/1055-9965.EPI-14-0683 [doi]
AB  - Both targeted and genome-wide studies have revealed genetic associations for 
      susceptibility, prognosis, and treatment-induced secondary malignancies and 
      toxicities in classical Hodgkin lymphoma (cHL). This review gives a systematic 
      and comprehensive overview of significant associations and places them into a 
      biologic context. The strongest susceptibility polymorphisms have been found for 
      the human leukocyte antigen (HLA) genes. These associations are specific for cHL 
      overall or for subgroups based on tumor cell Epstein-Barr virus (EBV) status. 
      These findings strongly suggest that EBV-specific immune responses influence cHL 
      susceptibility in EBV(+) cHL and that immune responses targeting other 
      tumor-associated antigens are important in EBV(-) cHL. Accordingly, most of the 
      numerous other susceptibility loci map to genes that affect functionality of the 
      immune system, underscoring the crucial role of the immune system in cHL 
      development. The number of association studies on cHL prognosis is limited with 
      one consistent association for the drug-metabolizing UGT1A1 gene. PRDM1 is 
      associated with radiation-induced secondary malignancies and a small number of 
      genes are associated with treatment-related toxicities. In conclusion, most loci 
      showing genetic associations in cHL harbor genes with a potential functional 
      relevance for cHL susceptibility.
CI  - (c)2014 American Association for Cancer Research.
FAU - Kushekhar, Kushi
AU  - Kushekhar K
AD  - Department of Pathology and Medical Biology, University of Groningen, University 
      Medical Centre Groningen, Groningen, the Netherlands.
FAU - van den Berg, Anke
AU  - van den Berg A
AD  - Department of Pathology and Medical Biology, University of Groningen, University 
      Medical Centre Groningen, Groningen, the Netherlands.
FAU - Nolte, Ilja
AU  - Nolte I
AD  - Department of Epidemiology, University of Groningen, University Medical Centre 
      Groningen, Groningen, the Netherlands.
FAU - Hepkema, Bouke
AU  - Hepkema B
AD  - Department of Laboratory Medicine, University of Groningen, University Medical 
      Centre Groningen, Groningen, the Netherlands.
FAU - Visser, Lydia
AU  - Visser L
AD  - Department of Pathology and Medical Biology, University of Groningen, University 
      Medical Centre Groningen, Groningen, the Netherlands.
FAU - Diepstra, Arjan
AU  - Diepstra A
AD  - Department of Pathology and Medical Biology, University of Groningen, University 
      Medical Centre Groningen, Groningen, the Netherlands. a.diepstra@umcg.nl.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
DEP - 20140909
PL  - United States
TA  - Cancer Epidemiol Biomarkers Prev
JT  - Cancer epidemiology, biomarkers & prevention : a publication of the American 
      Association for Cancer Research, cosponsored by the American Society of 
      Preventive Oncology
JID - 9200608
SB  - IM
MH  - Disease Susceptibility
MH  - Hodgkin Disease/*genetics/pathology
MH  - Humans
MH  - Prognosis
EDAT- 2014/09/11 06:00
MHDA- 2015/08/13 06:00
CRDT- 2014/09/11 06:00
PHST- 2014/09/11 06:00 [entrez]
PHST- 2014/09/11 06:00 [pubmed]
PHST- 2015/08/13 06:00 [medline]
AID - 1055-9965.EPI-14-0683 [pii]
AID - 10.1158/1055-9965.EPI-14-0683 [doi]
PST - ppublish
SO  - Cancer Epidemiol Biomarkers Prev. 2014 Dec;23(12):2737-47. doi: 
      10.1158/1055-9965.EPI-14-0683. Epub 2014 Sep 9.