PMID- 25205855
OWN - NLM
STAT- MEDLINE
DCOM- 20160120
LR  - 20181202
IS  - 1758-1001 (Electronic)
IS  - 0004-5632 (Linking)
VI  - 52
IP  - Pt 3
DP  - 2015 May
TI  - Heart-type fatty acid binding protein in early diagnosis of myocardial infarction 
      in the era of high-sensitivity troponin: a systematic review and meta-analysis.
PG  - 370-81
LID - 10.1177/0004563214553277 [doi]
AB  - INTRODUCTION: Heart-type fatty acid binding protein (HT FABP) is an emerging 
      biomarker of ischaemic myocardial necrosis. While previous studies have 
      demonstrated its additive value when compared to contemporary troponin assays in 
      the diagnosis of acute myocardial infarction (AMI), its utility in the era of 
      high-sensitivity troponin (hsTn) assays remains undetermined. METHODOLOGY: A 
      systematic review and meta-analysis of relevant studies was performed comparing 
      the diagnostic performance of HT FABP both alone and in conjunction with hsTn in 
      the early diagnosis and exclusion of AMI. RESULTS: A systematic literature search 
      yielded eight eligible studies including 3395 patients. Of these, 716 patients 
      (21.1%) were eventually diagnosed with AMI. The pooled sensitivity and 
      specificity for hsTn on admission was 82.5% (95% confidence interval [CI]: 
      79.8-85.0%) and 89.7% (95% CI: 88.7-90.6%), respectively, while the area under 
      the curve (AUC) for the summary receiver operating characteristics (ROC) curve is 
      0.92 (SE 0.02). While the pooled specificity (84.6%, 95% CI: 83.2-85.9%) of 
      admission HT FABP is similar to hsTn for the early diagnosis of AMI (P = 0.07), 
      its pooled sensitivity (63.5%, 95% CI: 59.9-67.1%, P < 0.001) is significantly 
      worse. Accordingly, the AUC of the summary ROC curve for HT FABP (0.79, SE 0.03) 
      is inferior to hsTn (P < 0.0001). The addition of HT FABP to hsTn resulted in no 
      improvement in the sensitivity (P = 0.058) and worsened the specificity (P = 
      0.001) in the early diagnosis of AMI compared to hsTn alone. CONCLUSION: HT FABP 
      does not appear to improve the diagnostic accuracy of hsTn, and consequently its 
      routine use currently cannot not be recommended.
CI  - (c) The Author(s) 2014 Reprints and permissions: 
      sagepub.co.uk/journalsPermissions.nav.
FAU - Liou, Kevin
AU  - Liou K
AD  - Eastern Heart Clinic, Prince of Wales Hospital, Sydney k_liou@hotmail.com.
FAU - Ho, Suyen
AU  - Ho S
AD  - Department of Anaesthetics, Royal Prince Alfred Hospital, Sydney.
FAU - Ooi, Sze-Yuan
AU  - Ooi SY
AD  - Eastern Heart Clinic, Prince of Wales Hospital, Sydney.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20140909
PL  - England
TA  - Ann Clin Biochem
JT  - Annals of clinical biochemistry
JID - 0324055
RN  - 0 (Biomarkers)
RN  - 0 (FABP3 protein, human)
RN  - 0 (Fatty Acid Binding Protein 3)
RN  - 0 (Fatty Acid-Binding Proteins)
RN  - 0 (Troponin T)
SB  - IM
MH  - Biomarkers/blood
MH  - Early Diagnosis
MH  - Fatty Acid Binding Protein 3
MH  - Fatty Acid-Binding Proteins/*analysis
MH  - Humans
MH  - Myocardial Infarction/*blood/*diagnosis
MH  - Troponin T/*blood
OTO - NOTNLM
OT  - Heart-type fatty acid binding protein
OT  - acute myocardial infarction
OT  - high-sensitivity troponin
EDAT- 2014/09/11 06:00
MHDA- 2016/01/21 06:00
CRDT- 2014/09/11 06:00
PHST- 2014/09/04 00:00 [accepted]
PHST- 2014/09/11 06:00 [entrez]
PHST- 2014/09/11 06:00 [pubmed]
PHST- 2016/01/21 06:00 [medline]
AID - 0004563214553277 [pii]
AID - 10.1177/0004563214553277 [doi]
PST - ppublish
SO  - Ann Clin Biochem. 2015 May;52(Pt 3):370-81. doi: 10.1177/0004563214553277. Epub 
      2014 Sep 9.