PMID- 25206037
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140910
LR  - 20240321
IS  - 0972-7531 (Print)
IS  - 0976-3260 (Electronic)
IS  - 0972-7531 (Linking)
VI  - 20
IP  - 4
DP  - 2013 Oct
TI  - Effect of subcutaneous injection of estradiol on feeding and drinking behaviors 
      and body weight in basolateral amygdaloid lesioned rats.
PG  - 139-44
LID - 10.5214/ans.0972.7531.200404 [doi]
AB  - BACKGROUND: Estradiol is known to inhibit food intake (FI), water intake (WI) and 
      body weight (BW) across the species including women and it is most evident in 
      rats. Ovariectomy in rats and menopause in women produce hyperphagia and obesity. 
      Estradiol substitution in ovariectomized (OVX) rats and hormone replacement in 
      women reverses these changes suggesting that lack of estradiol causes eating 
      related disorders. However, the neurobiological target/s for estradiol mediating 
      effects remains largely unknown. While lesions of basolateral amygdala (BLA) also 
      produce hyperphagia, polydipsia and obesity in female rats suggesting BLA 
      normally inhibits these behaviors. PURPOSE: Since ovariectomy is a useful model 
      to study postmenopausal obesity in women, we have investigated the role of BLA in 
      ovariectomy induced ingestive behaviors. METHODS: Ovariectomy and stereotaxic 
      lesions in experimental group (n = 6) whereas sham operations in control group (n 
      = 6) were carried out in female rats. Estradiol was injected subcutaneously (s.c) 
      before and after lesions in experimental group and vehicle was injected in 
      control group. RESULTS: Data from the present study shows that there was an 
      additional increase in FI, WI and BW in OVX animals following BLA lesions, but 
      this additive effect was small compared to sham operated controls. Conversely, 
      OVX rats with lesions have shown small but significant reductions in FI, WI, and 
      lost less BW, following s.c injection of estradiol compared to rats with intact 
      BLA. CONCLUSION: These findings suggest that ovariectomy and estradiol induced 
      changes on ingestive behaviors and body weight are partly mediated via BLA.
FAU - Rao, Bodepudi N
AU  - Rao BN
AD  - Department of Physiology, Shri Sathya Sai Medical College and Research Institute, 
      Ammapettai, Kancheepuram (Dist), Tamil Nadu;
FAU - Pal, Gopal K
AU  - Pal GK
AD  - Department of Physiology, Jawaharlal Institute of Postgraduate Medical Education 
      and Research (JIPMER), Puducherry, INDIA-605006.
FAU - Pravati, Pal
AU  - Pravati P
AD  - Department of Physiology, Jawaharlal Institute of Postgraduate Medical Education 
      and Research (JIPMER), Puducherry, INDIA-605006.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ann Neurosci
JT  - Annals of neurosciences
JID - 101523367
PMC - PMC4117138
OTO - NOTNLM
OT  - BLA
OT  - Body weight
OT  - Drinking
OT  - Estradiol
OT  - Feeding
COIS- Competing interests: None,
EDAT- 2014/09/11 06:00
MHDA- 2014/09/11 06:01
PMCR- 2013/10/01
CRDT- 2014/09/11 06:00
PHST- 2013/09/28 00:00 [received]
PHST- 2013/11/25 00:00 [revised]
PHST- 2013/12/11 00:00 [accepted]
PHST- 2014/09/11 06:00 [entrez]
PHST- 2014/09/11 06:00 [pubmed]
PHST- 2014/09/11 06:01 [medline]
PHST- 2013/10/01 00:00 [pmc-release]
AID - 200404 [pii]
AID - 10.5214/ans.0972.7531.200404 [doi]
PST - ppublish
SO  - Ann Neurosci. 2013 Oct;20(4):139-44. doi: 10.5214/ans.0972.7531.200404.