PMID- 2520639
OWN - NLM
STAT- MEDLINE
DCOM- 19920615
LR  - 20191029
IS  - 0888-6296 (Print)
IS  - 0888-6296 (Linking)
VI  - 3
IP  - 1
DP  - 1989 Feb
TI  - Sinus node function and protamine sulfate.
PG  - 44-51
AB  - This report analyzes the effects of protamine sulfate (PS) on the heart rate and 
      sinoatrial node function in dogs anesthetized with diazepam, fentanyl, and 
      pancuronium bromide, and subjected to different modalities of extracorporeal 
      circulation (ECC). All groups were given 3 mg/kg of heparin sodium and 5 mg/kg of 
      PS. The sinus node function was evaluated by means of sinoatrial conduction time 
      (SACT), absolute sinus node recovery time (SNRTa), and corrected sinus node 
      recovery time (SNRTc). The spontaneous heart rate (HR) of the animals was also 
      analyzed. Under the experimental conditions established in this study, the 
      intravenous administration of a bolus of PS produced a decrease in the HR in all 
      the groups, regardless of the type of ECC used. The modifications in the 
      conduction and recovery times of the sinus node by PS did not correlate with 
      those of the heart rate; the sinoatrial conduction time increased in groups 
      subjected to ECC, while the absolute and corrected recovery times of the sinus 
      node were prolonged only in the group that underwent rapid rewarming.
FAU - Alvarez, J
AU  - Alvarez J
AD  - Service of Anesthesia, Hospital Santa Cruz y San Pablo, Barcelona, Spain.
FAU - Alvarez, L
AU  - Alvarez L
FAU - Escudero, C
AU  - Escudero C
FAU - Castillo Olivares, J L
AU  - Castillo Olivares JL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Cardiothorac Anesth
JT  - Journal of cardiothoracic anesthesia
JID - 8709732
RN  - 0 (Cardioplegic Solutions)
RN  - 0 (Protamines)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Animals
MH  - Aorta/surgery
MH  - Blood Pressure/drug effects
MH  - Bundle of His/drug effects/physiology
MH  - Cardioplegic Solutions/administration & dosage
MH  - Central Venous Pressure/drug effects
MH  - Constriction
MH  - Dogs
MH  - Electrocardiography
MH  - *Extracorporeal Circulation
MH  - Heart Rate/*drug effects/physiology
MH  - Heparin/therapeutic use
MH  - Hypothermia, Induced
MH  - Myocardial Contraction/drug effects/physiology
MH  - Protamines/*pharmacology
MH  - Pulmonary Artery
MH  - Pulmonary Wedge Pressure/drug effects
MH  - Reaction Time/drug effects
MH  - Sinoatrial Node/*drug effects/physiology
MH  - Time Factors
EDAT- 1989/02/01 00:00
MHDA- 1989/02/01 00:01
CRDT- 1989/02/01 00:00
PHST- 1989/02/01 00:00 [pubmed]
PHST- 1989/02/01 00:01 [medline]
PHST- 1989/02/01 00:00 [entrez]
AID - 10.1016/0888-6296(89)90010-0 [doi]
PST - ppublish
SO  - J Cardiothorac Anesth. 1989 Feb;3(1):44-51. doi: 10.1016/0888-6296(89)90010-0.